Evaluation of multiple doses of tranexamic acid on blood loss in total knee arthroplasty

• Autor(a) principal: Elias Titonelli , Victor
• Data de Publicação: 2023
• Outros Autores: Mello Pavão, Douglas, Purita Paes Leme , Pedro, Teixeira Lobo , Renan Teixeira Lobo, Sattamini Pires e Albuquerque, Rodrigo, Branco de Sousa, Eduardo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Clinical and Biomedical Research
• Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/131668
• topic: Blood loss, surgical; Arthroplasty, replacement, knee; Osteoarthritis, knee; Tranexamic acid.

Objective: To evaluate the efficacy of multiple doses of tranexamic acid (TXA) in blood loss in patients undergoing total knee arthroplasty (TKA). Methods: Seven patients of both genders over 50 years old undergoingTKA, who received 15 mg/kg intravenous (IV) TXA 30 minutes before the surgical incision and another 3 doses thereafter were included in this report. Blood loss analysis included blood loss at the drain, hemoglobin loss, and estimated blood loss. Statistical analysis was performed. Results: There was a significant hemoglobin drop after 48 hours, compared to preoperative. Mean blood loss assessed by drain was 20.0 ± 25.17 mL after 24 h. Estimated blood loss was higher after 48 hours compared to 24 hours. No complications were reported in this sample, and no patient received transfusions. Conclusion: The use of TXA in multiple doses did not prevent the drop in postoperative hemoglobin levels and did not correlate with increased complications.