Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/73975 |
Resumo: | Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome |
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Factors that affect mother-to-child HIV transmission at a university hospital in southern BrazilRisk factorsinfectious disease transmissionvertical transmissionacquired immunodeficiency syndromeInfectious diseasesObjective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndromeHCPA/FAMED/UFRGS2017-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/73975Clinical & Biomedical Research; Vol. 37 No. 4 (2017): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 37 n. 4 (2017): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/73975/pdfCopyright (c) 2017 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessLeopoldino, Maria Aparecida AndrezaChaves, Eunice Beatriz Martinda Silva, Carmem Lúcia OliveiraCorleta, Helena von Eye2024-01-19T14:24:21Zoai:seer.ufrgs.br:article/73975Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:24:21Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
title |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
spellingShingle |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil Leopoldino, Maria Aparecida Andreza Risk factors infectious disease transmission vertical transmission acquired immunodeficiency syndrome Infectious diseases |
title_short |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
title_full |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
title_fullStr |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
title_full_unstemmed |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
title_sort |
Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil |
author |
Leopoldino, Maria Aparecida Andreza |
author_facet |
Leopoldino, Maria Aparecida Andreza Chaves, Eunice Beatriz Martin da Silva, Carmem Lúcia Oliveira Corleta, Helena von Eye |
author_role |
author |
author2 |
Chaves, Eunice Beatriz Martin da Silva, Carmem Lúcia Oliveira Corleta, Helena von Eye |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Leopoldino, Maria Aparecida Andreza Chaves, Eunice Beatriz Martin da Silva, Carmem Lúcia Oliveira Corleta, Helena von Eye |
dc.subject.por.fl_str_mv |
Risk factors infectious disease transmission vertical transmission acquired immunodeficiency syndrome Infectious diseases |
topic |
Risk factors infectious disease transmission vertical transmission acquired immunodeficiency syndrome Infectious diseases |
description |
Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/73975 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/73975 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/73975/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Clinical and Biomedical Research info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Clinical and Biomedical Research |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 37 No. 4 (2017): Clinical and Biomedical Research Clinical and Biomedical Research; v. 37 n. 4 (2017): Clinical and Biomedical Research 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
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1799767054203486208 |