Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil

Detalhes bibliográficos
Autor(a) principal: Leopoldino, Maria Aparecida Andreza
Data de Publicação: 2017
Outros Autores: Chaves, Eunice Beatriz Martin, da Silva, Carmem Lúcia Oliveira, Corleta, Helena von Eye
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/73975
Resumo: Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome
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spelling Factors that affect mother-to-child HIV transmission at a university hospital in southern BrazilRisk factorsinfectious disease transmissionvertical transmissionacquired immunodeficiency syndromeInfectious diseasesObjective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndromeHCPA/FAMED/UFRGS2017-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/73975Clinical & Biomedical Research; Vol. 37 No. 4 (2017): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 37 n. 4 (2017): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/73975/pdfCopyright (c) 2017 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessLeopoldino, Maria Aparecida AndrezaChaves, Eunice Beatriz Martinda Silva, Carmem Lúcia OliveiraCorleta, Helena von Eye2024-01-19T14:24:21Zoai:seer.ufrgs.br:article/73975Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:24:21Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
title Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
spellingShingle Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
Leopoldino, Maria Aparecida Andreza
Risk factors
infectious disease transmission
vertical transmission
acquired immunodeficiency syndrome
Infectious diseases
title_short Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
title_full Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
title_fullStr Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
title_full_unstemmed Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
title_sort Factors that affect mother-to-child HIV transmission at a university hospital in southern Brazil
author Leopoldino, Maria Aparecida Andreza
author_facet Leopoldino, Maria Aparecida Andreza
Chaves, Eunice Beatriz Martin
da Silva, Carmem Lúcia Oliveira
Corleta, Helena von Eye
author_role author
author2 Chaves, Eunice Beatriz Martin
da Silva, Carmem Lúcia Oliveira
Corleta, Helena von Eye
author2_role author
author
author
dc.contributor.author.fl_str_mv Leopoldino, Maria Aparecida Andreza
Chaves, Eunice Beatriz Martin
da Silva, Carmem Lúcia Oliveira
Corleta, Helena von Eye
dc.subject.por.fl_str_mv Risk factors
infectious disease transmission
vertical transmission
acquired immunodeficiency syndrome
Infectious diseases
topic Risk factors
infectious disease transmission
vertical transmission
acquired immunodeficiency syndrome
Infectious diseases
description Objective: To evaluate factors that may interfere in mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV).Method: A historical cohort study with a sample of 299 HIV-infected mothers and their newborns who delivered at the Obstetric Center of the Hospital de Clínicas de Porto Alegre, southern Brazil, from January 2010 to December 2014.Results: Of the 299 newborns of HIV-infected mothers, 3.7% (n = 11) were infected. Of those, 90.9% (n = 10) were born by cesarean section; 90.9% (n = 10) had ≥ 37 weeks; 54.6% (n = 6) received zidovudine starting within the first 4 hours after birth; and 45.4% (n = 5) received zidovudine and nevirapine. Four women whose newborns were infected with HIV had syphilis during pregnancy (36.4%). Poor adherence to highly active antiretroviral therapy (HAART) (p < 0.003), viral load ≥ 1000 copies/mL or ignored in the third trimester (p < 0.000), and CD4 count < 500 cells/mm3 in the third trimester (p < 0.046) were significantly associated with an increased risk of MTCT.Conclusion: Lack of control of risk factors may contribute to unfavorable rates of MTCT of HIV.Keywords: Risk factors; infectious disease transmission; vertical transmission; acquired immunodeficiency syndrome
publishDate 2017
dc.date.none.fl_str_mv 2017-12-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/73975
url https://seer.ufrgs.br/index.php/hcpa/article/view/73975
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/73975/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2017 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 37 No. 4 (2017): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 37 n. 4 (2017): Clinical and Biomedical Research
2357-9730
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instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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