Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic

Detalhes bibliográficos
Autor(a) principal: Pivatto Júnior, Fernando
Data de Publicação: 2014
Outros Autores: Luis Ferreira da Silva, André, Bárbara Marina Simionato, Bárbara, Fuzinatto, Fernanda, De Conto Oliveira, Jerônimo, Martins Pires, Leonardo, Cristina Petry, Roberta, Selbach Scheffel, Rafael, Carlos Amon, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/44802
Resumo: Introduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an anticoagulation outpatient clinic; and to describe the profile of this population of patients in terms of risk of stroke, as well as the occurrence of adverse events during the follow-up.Methods: Retrospective cohort study involving patients of the anticoagulation outpatient clinic of the Department of Internal Medicine at Hospital de Clínicas de Porto Alegre. We evaluated outpatient visits, hospital admissions, and emergency visits from January to December 2011. TTR was calculated using the Rosendaal method.Results: Sixty-three patients were investigated. Their mean age was 74.3±10.9 years. The CHADS2 score was ≥ 4 in 44.5% of the patients; 63.5% of them had a CHA2DS2-VASc score ≥ 5. The TTR was 64.8%. During follow-up, the incidence of overall bleeding was 31.7%, with major and minor bleeding rates of 4.8% and 34.9%, respectively. There were no other complications related to AF or anticoagulation.Conclusion: The patients achieved a TTR of 64.8% during follow-up, which is deemed appropriate and in agreement with the literature. Patients had high risk for stroke, and the incidence of minor bleeding was higher than the rate found in the literature, whereas the incidence of major bleeding was similar to the one found in previous studies.
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spelling Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinicAnticoagulantswarfarinphenprocoumonatrial fibrillationinternship and residencyanticoagulantsIntroduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an anticoagulation outpatient clinic; and to describe the profile of this population of patients in terms of risk of stroke, as well as the occurrence of adverse events during the follow-up.Methods: Retrospective cohort study involving patients of the anticoagulation outpatient clinic of the Department of Internal Medicine at Hospital de Clínicas de Porto Alegre. We evaluated outpatient visits, hospital admissions, and emergency visits from January to December 2011. TTR was calculated using the Rosendaal method.Results: Sixty-three patients were investigated. Their mean age was 74.3±10.9 years. The CHADS2 score was ≥ 4 in 44.5% of the patients; 63.5% of them had a CHA2DS2-VASc score ≥ 5. The TTR was 64.8%. During follow-up, the incidence of overall bleeding was 31.7%, with major and minor bleeding rates of 4.8% and 34.9%, respectively. There were no other complications related to AF or anticoagulation.Conclusion: The patients achieved a TTR of 64.8% during follow-up, which is deemed appropriate and in agreement with the literature. Patients had high risk for stroke, and the incidence of minor bleeding was higher than the rate found in the literature, whereas the incidence of major bleeding was similar to the one found in previous studies.HCPA/FAMED/UFRGS2014-06-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/44802Clinical & Biomedical Research; Vol. 34 No. 2 (2014): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 34 n. 2 (2014): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/44802/30856Pivatto Júnior, FernandoLuis Ferreira da Silva, AndréBárbara Marina Simionato, BárbaraFuzinatto, FernandaDe Conto Oliveira, JerônimoMartins Pires, LeonardoCristina Petry, RobertaSelbach Scheffel, RafaelCarlos Amon, Luísinfo:eu-repo/semantics/openAccess2024-01-19T13:30:44Zoai:seer.ufrgs.br:article/44802Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T13:30:44Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
title Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
spellingShingle Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
Pivatto Júnior, Fernando
Anticoagulants
warfarin
phenprocoumon
atrial fibrillation
internship and residency
anticoagulants
title_short Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
title_full Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
title_fullStr Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
title_full_unstemmed Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
title_sort Management of anticoagulation with vitamin K antagonists in a tertiary hospital outpatient clinic
author Pivatto Júnior, Fernando
author_facet Pivatto Júnior, Fernando
Luis Ferreira da Silva, André
Bárbara Marina Simionato, Bárbara
Fuzinatto, Fernanda
De Conto Oliveira, Jerônimo
Martins Pires, Leonardo
Cristina Petry, Roberta
Selbach Scheffel, Rafael
Carlos Amon, Luís
author_role author
author2 Luis Ferreira da Silva, André
Bárbara Marina Simionato, Bárbara
Fuzinatto, Fernanda
De Conto Oliveira, Jerônimo
Martins Pires, Leonardo
Cristina Petry, Roberta
Selbach Scheffel, Rafael
Carlos Amon, Luís
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pivatto Júnior, Fernando
Luis Ferreira da Silva, André
Bárbara Marina Simionato, Bárbara
Fuzinatto, Fernanda
De Conto Oliveira, Jerônimo
Martins Pires, Leonardo
Cristina Petry, Roberta
Selbach Scheffel, Rafael
Carlos Amon, Luís
dc.subject.por.fl_str_mv Anticoagulants
warfarin
phenprocoumon
atrial fibrillation
internship and residency
anticoagulants
topic Anticoagulants
warfarin
phenprocoumon
atrial fibrillation
internship and residency
anticoagulants
description Introduction: atrial fibrillation (AF) is one of the main risk factors for stroke. Vitamin K antagonists (VKA) reduce this risk, and the effectiveness of this treatment is directly related to time in therapeutic range (TTR). This study aimed to report the TTR in patients with non-valvular AF at an anticoagulation outpatient clinic; and to describe the profile of this population of patients in terms of risk of stroke, as well as the occurrence of adverse events during the follow-up.Methods: Retrospective cohort study involving patients of the anticoagulation outpatient clinic of the Department of Internal Medicine at Hospital de Clínicas de Porto Alegre. We evaluated outpatient visits, hospital admissions, and emergency visits from January to December 2011. TTR was calculated using the Rosendaal method.Results: Sixty-three patients were investigated. Their mean age was 74.3±10.9 years. The CHADS2 score was ≥ 4 in 44.5% of the patients; 63.5% of them had a CHA2DS2-VASc score ≥ 5. The TTR was 64.8%. During follow-up, the incidence of overall bleeding was 31.7%, with major and minor bleeding rates of 4.8% and 34.9%, respectively. There were no other complications related to AF or anticoagulation.Conclusion: The patients achieved a TTR of 64.8% during follow-up, which is deemed appropriate and in agreement with the literature. Patients had high risk for stroke, and the incidence of minor bleeding was higher than the rate found in the literature, whereas the incidence of major bleeding was similar to the one found in previous studies.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/44802
url https://seer.ufrgs.br/index.php/hcpa/article/view/44802
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/44802/30856
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 34 No. 2 (2014): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 34 n. 2 (2014): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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