Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil

Detalhes bibliográficos
Autor(a) principal: Longo, Larisse
Data de Publicação: 2017
Outros Autores: Ferrari, Jéssica Tonin, Hoss, Giovana Regina Weber, Fratta, Leila Xavier Sinigaglia, Vieira, Sandra Maria Gonçalves, da Silveira, Themis Reverbel, Silva, Fernando Antônio de Abreu e, Sanseverino, Maria Teresa Vieira, Santos, Jorge Luiz dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/71572
Resumo: Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.Keywords: Biliary atresia; environmental risk factor; etiology; seasonality; smoking
id UFRGS-20_98339f1a3fc7149077f2087a38c344c3
oai_identifier_str oai:seer.ufrgs.br:article/71572
network_acronym_str UFRGS-20
network_name_str Clinical and Biomedical Research
repository_id_str
spelling Environmental risk factors associated with biliary atresia in Rio Grande do Sul, BrazilBiliary atresiaenvironmental risk factoretiologyseasonalitysmokingBiliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.Keywords: Biliary atresia; environmental risk factor; etiology; seasonality; smokingHCPA/FAMED/UFRGS2017-07-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/71572Clinical & Biomedical Research; Vol. 37 No. 2 (2017): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 37 n. 2 (2017): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/71572/pdfCopyright (c) 2017 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessLongo, LarisseFerrari, Jéssica ToninHoss, Giovana Regina WeberFratta, Leila Xavier SinigagliaVieira, Sandra Maria Gonçalvesda Silveira, Themis ReverbelSilva, Fernando Antônio de Abreu eSanseverino, Maria Teresa VieiraSantos, Jorge Luiz dos2024-01-19T14:24:48Zoai:seer.ufrgs.br:article/71572Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:24:48Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
title Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
spellingShingle Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
Longo, Larisse
Biliary atresia
environmental risk factor
etiology
seasonality
smoking
title_short Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
title_full Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
title_fullStr Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
title_full_unstemmed Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
title_sort Environmental risk factors associated with biliary atresia in Rio Grande do Sul, Brazil
author Longo, Larisse
author_facet Longo, Larisse
Ferrari, Jéssica Tonin
Hoss, Giovana Regina Weber
Fratta, Leila Xavier Sinigaglia
Vieira, Sandra Maria Gonçalves
da Silveira, Themis Reverbel
Silva, Fernando Antônio de Abreu e
Sanseverino, Maria Teresa Vieira
Santos, Jorge Luiz dos
author_role author
author2 Ferrari, Jéssica Tonin
Hoss, Giovana Regina Weber
Fratta, Leila Xavier Sinigaglia
Vieira, Sandra Maria Gonçalves
da Silveira, Themis Reverbel
Silva, Fernando Antônio de Abreu e
Sanseverino, Maria Teresa Vieira
Santos, Jorge Luiz dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Longo, Larisse
Ferrari, Jéssica Tonin
Hoss, Giovana Regina Weber
Fratta, Leila Xavier Sinigaglia
Vieira, Sandra Maria Gonçalves
da Silveira, Themis Reverbel
Silva, Fernando Antônio de Abreu e
Sanseverino, Maria Teresa Vieira
Santos, Jorge Luiz dos
dc.subject.por.fl_str_mv Biliary atresia
environmental risk factor
etiology
seasonality
smoking
topic Biliary atresia
environmental risk factor
etiology
seasonality
smoking
description Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient’s genetic constitution. This study aimed to analyze information concerning environmental risk factors associated with BA in southern Brazil. A case-control study with mothers of patients with BA and mothers of patients with cystic fibrosis (CF) was conducted. Inquiry included questions related to exposition to environmental risk factors during the periconceptional and gestational (second and third trimesters) periods. Mothers of BA patients had smoked during pregnancy more frequently in comparison with the mothers of CF patients, but no significant difference was found in a multivariate analysis. There was no between group difference in terms of seasonality, but the multivariate analysis showed a significant difference within the BA group between date of conception in winter compared to other seasons. In conclusion, smoking during pregnancy seemed to increase the risk of BA while date of conception in winter decreased it.Keywords: Biliary atresia; environmental risk factor; etiology; seasonality; smoking
publishDate 2017
dc.date.none.fl_str_mv 2017-07-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/71572
url https://seer.ufrgs.br/index.php/hcpa/article/view/71572
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/71572/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2017 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 37 No. 2 (2017): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 37 n. 2 (2017): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
_version_ 1799767054174126080