Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis

Detalhes bibliográficos
Autor(a) principal: M. G. Vieira, Sandra
Data de Publicação: 2022
Outros Autores: Amaral, Beatriz, R. de Oliveira, Jarbas, R. da Silveira, Themis
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125023
Resumo: Hepatic osteodystrophy is the term used to define the metabolic bone diseaseassociated with chronic liver disease. It has been studied mainly in adults with chroniccholestasis, but it is equally prevalent in children and adolescents. The pathogenesisof hepatic osteodystrophy is unknown, however, it is likely to be multifactorial. Themajority of patients experience a progressive loss of bone mineral density, which causesskeletal fragility. Thus, patients are predisposed to loss of height, to bone pain, and tofracturing bones with minimal or no trauma. Bone mineral density may be measuredby dual photon absorptiometry. No specific therapy is available to treat or prevent theosteopenia of chronic liver disease. However, 1 year after liver transplant, most patientsdo regain bone mass. This review discusses the pathophysiology, diagnosis, andtreatment of hepatic osteodystrophy. In this review we also report our personal experience with 20 children and adolescents with chronic cholestasis receiving care atthe Pediatric Gastroenterology Unit at Hospital de Clínicas de Porto Alegre.
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spelling Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasisOsteodistrofia hepática: : revisão da literatura e relato de experiência pessoal em um grupo de crianças e adolescentes com colestase crônicaHepatic osteodystrophycholestatic osteopeniachronic liver diseaseOsteodistrofia hepáticaosteopenia colestáticahepatopatia crônicaHepatic osteodystrophy is the term used to define the metabolic bone diseaseassociated with chronic liver disease. It has been studied mainly in adults with chroniccholestasis, but it is equally prevalent in children and adolescents. The pathogenesisof hepatic osteodystrophy is unknown, however, it is likely to be multifactorial. Themajority of patients experience a progressive loss of bone mineral density, which causesskeletal fragility. Thus, patients are predisposed to loss of height, to bone pain, and tofracturing bones with minimal or no trauma. Bone mineral density may be measuredby dual photon absorptiometry. No specific therapy is available to treat or prevent theosteopenia of chronic liver disease. However, 1 year after liver transplant, most patientsdo regain bone mass. This review discusses the pathophysiology, diagnosis, andtreatment of hepatic osteodystrophy. In this review we also report our personal experience with 20 children and adolescents with chronic cholestasis receiving care atthe Pediatric Gastroenterology Unit at Hospital de Clínicas de Porto Alegre.Osteodistrofia hepática é o termo usado para definir a doença óssea metabólicaassociada à hepatopatia crônica. Estudada principalmente em indivíduos adultos comcolestase crônica, é igualmente prevalente em crianças e adolescentes hepatopatascrônicos. A patogênese é desconhecida mas parece ser multifatorial. Na maioria dospacientes, ocorre uma perda progressiva de densidade óssea, a qual causa importantefragilidade esquelética. Esta predispõe à perda de estatura, dor óssea e surgimentode fraturas associadas ou não a trauma. A densidade óssea mineral pode ser medidapor densitometria óssea de dupla emissão. Nenhuma medida, farmacológica ouprofilática, tem se mostrado efetiva em reduzir a osteopenia da hepatopatia crônica.Todavia, aproximadamente 1 ano após transplante hepático, observa-se aquisiçãode massa óssea em grande parte dos pacientes.Nesta revisão discutimos a fisiopatologia, o diagnóstico e o tratamento da osteodistrofiahepática e relatamos a nossa experiência com 20 pacientes com colestase crônicaacompanhados na unidade de Gastroenterologia Pediátrica do Hospital de Clínicasde Porto Alegre.HCPA/FAMED/UFRGS2022-06-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article"A Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125023Clinical & Biomedical Research; Vol. 18 No. 3 (1998): Periodical HCPAClinical and Biomedical Research; v. 18 n. 3 (1998): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125023/85101http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessM. G. Vieira, Sandra Amaral, Beatriz R. de Oliveira, Jarbas R. da Silveira, Themis 2022-09-16T16:32:29Zoai:seer.ufrgs.br:article/125023Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-09-16T16:32:29Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
Osteodistrofia hepática: : revisão da literatura e relato de experiência pessoal em um grupo de crianças e adolescentes com colestase crônica
title Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
spellingShingle Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
M. G. Vieira, Sandra
Hepatic osteodystrophy
cholestatic osteopenia
chronic liver disease
Osteodistrofia hepática
osteopenia colestática
hepatopatia crônica
title_short Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
title_full Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
title_fullStr Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
title_full_unstemmed Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
title_sort Hepatic osteodystrophy: : literature review and report of a personal experience with children and adolescents with chronic cholestasis
author M. G. Vieira, Sandra
author_facet M. G. Vieira, Sandra
Amaral, Beatriz
R. de Oliveira, Jarbas
R. da Silveira, Themis
author_role author
author2 Amaral, Beatriz
R. de Oliveira, Jarbas
R. da Silveira, Themis
author2_role author
author
author
dc.contributor.author.fl_str_mv M. G. Vieira, Sandra
Amaral, Beatriz
R. de Oliveira, Jarbas
R. da Silveira, Themis
dc.subject.por.fl_str_mv Hepatic osteodystrophy
cholestatic osteopenia
chronic liver disease
Osteodistrofia hepática
osteopenia colestática
hepatopatia crônica
topic Hepatic osteodystrophy
cholestatic osteopenia
chronic liver disease
Osteodistrofia hepática
osteopenia colestática
hepatopatia crônica
description Hepatic osteodystrophy is the term used to define the metabolic bone diseaseassociated with chronic liver disease. It has been studied mainly in adults with chroniccholestasis, but it is equally prevalent in children and adolescents. The pathogenesisof hepatic osteodystrophy is unknown, however, it is likely to be multifactorial. Themajority of patients experience a progressive loss of bone mineral density, which causesskeletal fragility. Thus, patients are predisposed to loss of height, to bone pain, and tofracturing bones with minimal or no trauma. Bone mineral density may be measuredby dual photon absorptiometry. No specific therapy is available to treat or prevent theosteopenia of chronic liver disease. However, 1 year after liver transplant, most patientsdo regain bone mass. This review discusses the pathophysiology, diagnosis, andtreatment of hepatic osteodystrophy. In this review we also report our personal experience with 20 children and adolescents with chronic cholestasis receiving care atthe Pediatric Gastroenterology Unit at Hospital de Clínicas de Porto Alegre.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article"
A Convite dos Editores
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125023
url https://seer.ufrgs.br/index.php/hcpa/article/view/125023
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125023/85101
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 18 No. 3 (1998): Periodical HCPA
Clinical and Biomedical Research; v. 18 n. 3 (1998): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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