The protein/creatinine ratio in hypertensive pregnant women
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/125339 |
Resumo: | OBJECTIVE: To determine optimal protein/creatinine ratio for positive predictive value of significant proteinuria in pregnant women with systemic arterial hypertension. PATIENTS AND METHODS: We carried out a review of the literature with the objective of obtaining correlation coefficients of protein/creatinine ratio and 24-hour proteinuria. RESULTS: The correlation coefficient for protein/creatinine ratio and 24-hour proteinuria was 0.94 (0.53-0.98). There was no significant difference between the results obtained at different times of the day. We present an ROC curve of the analysis of sensitivity and specificity of the ratio for the diagnosis of significant proteinuria (> 300 mg in 24 hours). Specificity and positive predictive values were of 100 % for a ratio of > 0.8. The optimum values of sensitivity (0.96), specificity (0.96), positive predictive value (0.96), and negative predictive value (0.96) for the diagnosis of proteinuria > 300 mg in 24 hours occurred when the protein/creatinine ratio was 0.5 mg/mg. CONCLUSIONS: The protein/creatinine ratio of random urine samples from hypertensive pregnant women presented good sensitivity and specificity for the diagnosis of proteinuria > 300 mg in 24 hours and strong correlation with 24-hour proteinuria. A ratio of 0.5 mg/mg presented a significant positive predictive value for proteinuria and can be used in the diagnosis of hypertensive pregnant women. |
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Clinical and Biomedical Research |
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The protein/creatinine ratio in hypertensive pregnant womenÍndice proteinúria/creatininúria em gestantes com hipertensão arterialProteinúriacreatininúriagestanteshipertensãoProteinuriacreatininuriapregnant womenhypertensionOBJECTIVE: To determine optimal protein/creatinine ratio for positive predictive value of significant proteinuria in pregnant women with systemic arterial hypertension. PATIENTS AND METHODS: We carried out a review of the literature with the objective of obtaining correlation coefficients of protein/creatinine ratio and 24-hour proteinuria. RESULTS: The correlation coefficient for protein/creatinine ratio and 24-hour proteinuria was 0.94 (0.53-0.98). There was no significant difference between the results obtained at different times of the day. We present an ROC curve of the analysis of sensitivity and specificity of the ratio for the diagnosis of significant proteinuria (> 300 mg in 24 hours). Specificity and positive predictive values were of 100 % for a ratio of > 0.8. The optimum values of sensitivity (0.96), specificity (0.96), positive predictive value (0.96), and negative predictive value (0.96) for the diagnosis of proteinuria > 300 mg in 24 hours occurred when the protein/creatinine ratio was 0.5 mg/mg. CONCLUSIONS: The protein/creatinine ratio of random urine samples from hypertensive pregnant women presented good sensitivity and specificity for the diagnosis of proteinuria > 300 mg in 24 hours and strong correlation with 24-hour proteinuria. A ratio of 0.5 mg/mg presented a significant positive predictive value for proteinuria and can be used in the diagnosis of hypertensive pregnant women. OBJETIVO: Estabelecer o nível da relação proteína/ creatinina urinária com melhor predição para o diagnóstico de proteinúria significativa em gestantes com hipertensão arterial sistêmica. MATERIAIS E MÉTODOS: Uma revisão de literatura, que compara coeficientes de correlação entre a proteinúria de 24 horas e o índice proteína/creatinina urinária, busca cumprir o objetivo do presente trabalho. RESULTADOS: O coeficiente de correlação entre a proteinúria de 24 horas e o índice proteína/creatinina urinária encontrado foi de 0,94 (0,53-0,98). Não foi achada diferença significativa entre as medidas do índice pelos períodos variados do dia. É demonstrada uma curva ROC através da análise da sensibilidade e especificidade do índice para o diagnóstico de proteinúria significativa (> 300 mg/24 horas). A especificidade e o valor preditivo positivo foram de 100% para um índice > 0,8. Os melhores valores de sensibilidade (0,96), especificidade (0,96) e valores preditivos positivo (0,96) e negativo (0,96) para o diagnóstico de proteinúria > 300 mg/24 horas ocorreram quando o índice proteína/creatinina foi de 0,5 mg/mg. CONCLUSÕES: O índice proteinúria/creatininúria, em amostra aleatória de urina de gestantes com hipertensão arterial, apresenta boa sensibilidade e especificidade para o diagnóstico de proteinúria > 300 mg/24 horas e uma forte correlação com a proteinúria de 24 horas. Um índice de 0,5 mg/mg apresenta uma predição de proteinúria significativa, podendo ser utilizado para o diagnóstico em gestantes com hipertensão arterial.HCPA/FAMED/UFRGS2022-06-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article"A Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125339Clinical & Biomedical Research; Vol. 20 No. 2 (2000): Revista HCPAClinical and Biomedical Research; v. 20 n. 2 (2000): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125339/85220http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessL. Ramos, José GeraldoG. Barros, Elvino Martins-Costa, Sérgio 2022-09-16T16:33:08Zoai:seer.ufrgs.br:article/125339Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-09-16T16:33:08Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
The protein/creatinine ratio in hypertensive pregnant women Índice proteinúria/creatininúria em gestantes com hipertensão arterial |
title |
The protein/creatinine ratio in hypertensive pregnant women |
spellingShingle |
The protein/creatinine ratio in hypertensive pregnant women L. Ramos, José Geraldo Proteinúria creatininúria gestantes hipertensão Proteinuria creatininuria pregnant women hypertension |
title_short |
The protein/creatinine ratio in hypertensive pregnant women |
title_full |
The protein/creatinine ratio in hypertensive pregnant women |
title_fullStr |
The protein/creatinine ratio in hypertensive pregnant women |
title_full_unstemmed |
The protein/creatinine ratio in hypertensive pregnant women |
title_sort |
The protein/creatinine ratio in hypertensive pregnant women |
author |
L. Ramos, José Geraldo |
author_facet |
L. Ramos, José Geraldo G. Barros, Elvino Martins-Costa, Sérgio |
author_role |
author |
author2 |
G. Barros, Elvino Martins-Costa, Sérgio |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
L. Ramos, José Geraldo G. Barros, Elvino Martins-Costa, Sérgio |
dc.subject.por.fl_str_mv |
Proteinúria creatininúria gestantes hipertensão Proteinuria creatininuria pregnant women hypertension |
topic |
Proteinúria creatininúria gestantes hipertensão Proteinuria creatininuria pregnant women hypertension |
description |
OBJECTIVE: To determine optimal protein/creatinine ratio for positive predictive value of significant proteinuria in pregnant women with systemic arterial hypertension. PATIENTS AND METHODS: We carried out a review of the literature with the objective of obtaining correlation coefficients of protein/creatinine ratio and 24-hour proteinuria. RESULTS: The correlation coefficient for protein/creatinine ratio and 24-hour proteinuria was 0.94 (0.53-0.98). There was no significant difference between the results obtained at different times of the day. We present an ROC curve of the analysis of sensitivity and specificity of the ratio for the diagnosis of significant proteinuria (> 300 mg in 24 hours). Specificity and positive predictive values were of 100 % for a ratio of > 0.8. The optimum values of sensitivity (0.96), specificity (0.96), positive predictive value (0.96), and negative predictive value (0.96) for the diagnosis of proteinuria > 300 mg in 24 hours occurred when the protein/creatinine ratio was 0.5 mg/mg. CONCLUSIONS: The protein/creatinine ratio of random urine samples from hypertensive pregnant women presented good sensitivity and specificity for the diagnosis of proteinuria > 300 mg in 24 hours and strong correlation with 24-hour proteinuria. A ratio of 0.5 mg/mg presented a significant positive predictive value for proteinuria and can be used in the diagnosis of hypertensive pregnant women. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article" A Convite dos Editores |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/125339 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/125339 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/125339/85220 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 20 No. 2 (2000): Revista HCPA Clinical and Biomedical Research; v. 20 n. 2 (2000): Revista HCPA 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
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1799767056947609600 |