Gastric carcinogenesis

Detalhes bibliográficos
Autor(a) principal: de Marco F. Kaminski, Eliane
Data de Publicação: 2022
Outros Autores: Dario P. Kruel, Cleber
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125716
Resumo: In this study, we review aspects of the carcinogenesis, epidemiology, risk factors, and molecular biology related to gastric cancer. We also review experimental models of carcinogenesis that use exogenous drugs or gastric surgery to induce cancer. The importance of duodenogastric reflux, of endogenous formation of N-nitroso compounds, and of the potential enhancing effects of bile acid on stomach tumorigenesis are discussed.
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spelling Gastric carcinogenesisCarcinogênese gástricaCarcinoma gástricorefluxo duodeno-gástricocarcinogênese gástrica experimentalcâncer do coto gástricocompostos nitrosadosGastric carcinomaduodenogastric refluxexperimental gastriccarcinogenesiscancer of the gastric stumpN-nitroso compoundsIn this study, we review aspects of the carcinogenesis, epidemiology, risk factors, and molecular biology related to gastric cancer. We also review experimental models of carcinogenesis that use exogenous drugs or gastric surgery to induce cancer. The importance of duodenogastric reflux, of endogenous formation of N-nitroso compounds, and of the potential enhancing effects of bile acid on stomach tumorigenesis are discussed.Neste estudo, são revisados tópicos da carcinogênese gástrica, aspectos epidemiológicos, principais fatores de risco e biologia molecular no câncer de estômago. Também são revisados os modelos experimentais de carcinogênese que utilizam carcinógenos exógenos e os que induzem o câncer através de diferentes técnicas cirúrgicas. Discute-se a importância do refluxo do conteúdo duodenal para o estômago (refluxo duodeno-gástrico – RDG), a formação endógena de compostos nitrosos e o potencial efeito nocivo dos ácidos biliares para a mucosa gástrica.HCPA/FAMED/UFRGS2022-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article"A Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125716Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPAClinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125716/85371http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessde Marco F. Kaminski, Eliane Dario P. Kruel, Cleber 2022-07-07T12:08:10Zoai:seer.ufrgs.br:article/125716Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-07-07T12:08:10Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Gastric carcinogenesis
Carcinogênese gástrica
title Gastric carcinogenesis
spellingShingle Gastric carcinogenesis
de Marco F. Kaminski, Eliane
Carcinoma gástrico
refluxo duodeno-gástrico
carcinogênese gástrica experimental
câncer do coto gástrico
compostos nitrosados
Gastric carcinoma
duodenogastric reflux
experimental gastric
carcinogenesis
cancer of the gastric stump
N-nitroso compounds
title_short Gastric carcinogenesis
title_full Gastric carcinogenesis
title_fullStr Gastric carcinogenesis
title_full_unstemmed Gastric carcinogenesis
title_sort Gastric carcinogenesis
author de Marco F. Kaminski, Eliane
author_facet de Marco F. Kaminski, Eliane
Dario P. Kruel, Cleber
author_role author
author2 Dario P. Kruel, Cleber
author2_role author
dc.contributor.author.fl_str_mv de Marco F. Kaminski, Eliane
Dario P. Kruel, Cleber
dc.subject.por.fl_str_mv Carcinoma gástrico
refluxo duodeno-gástrico
carcinogênese gástrica experimental
câncer do coto gástrico
compostos nitrosados
Gastric carcinoma
duodenogastric reflux
experimental gastric
carcinogenesis
cancer of the gastric stump
N-nitroso compounds
topic Carcinoma gástrico
refluxo duodeno-gástrico
carcinogênese gástrica experimental
câncer do coto gástrico
compostos nitrosados
Gastric carcinoma
duodenogastric reflux
experimental gastric
carcinogenesis
cancer of the gastric stump
N-nitroso compounds
description In this study, we review aspects of the carcinogenesis, epidemiology, risk factors, and molecular biology related to gastric cancer. We also review experimental models of carcinogenesis that use exogenous drugs or gastric surgery to induce cancer. The importance of duodenogastric reflux, of endogenous formation of N-nitroso compounds, and of the potential enhancing effects of bile acid on stomach tumorigenesis are discussed.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article"
A Convite dos Editores
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125716
url https://seer.ufrgs.br/index.php/hcpa/article/view/125716
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125716/85371
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPA
Clinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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