The Molecular biology of gastrointestinal tumors

Detalhes bibliográficos
Autor(a) principal: F. Dillenburg, Carlos
Data de Publicação: 2022
Outros Autores: Moreira, Luis Fernando
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125713
Resumo: Remarkable improvements in the understanding of the development of human cancer and of its genetic nature have been reported. At our services, we have observed that there is a high incidence of gastrointestinal tumors in our region and, also, that poor prognosis occurs due to patients presenting with advanced stages of the disease. In this sense, it is expected that molecular biology studies will bring new hope for more effective diagnostic and treatment methods. Consequently, it is our objective to address the current aspects on colorectal, gastric, and esophageal carcinogenesis and the genes and products involved. The application of recent findings, used for early diagnosis, the existence of markers for prognosis, and the possibility of using new methods of treatment are discussed.
id UFRGS-20_e9169f817bc47bb80d7a12468324973b
oai_identifier_str oai:seer.ufrgs.br:article/125713
network_acronym_str UFRGS-20
network_name_str Clinical and Biomedical Research
repository_id_str
spelling The Molecular biology of gastrointestinal tumorsBiologia molecular dos tumores do trato digestivoBiologia moleculardigestivogastrointestinaistumorescarcinogêneseoncogeneseMolecular biologydigestive systemgastrointestinal systemtumorscarcinogenesisRemarkable improvements in the understanding of the development of human cancer and of its genetic nature have been reported. At our services, we have observed that there is a high incidence of gastrointestinal tumors in our region and, also, that poor prognosis occurs due to patients presenting with advanced stages of the disease. In this sense, it is expected that molecular biology studies will bring new hope for more effective diagnostic and treatment methods. Consequently, it is our objective to address the current aspects on colorectal, gastric, and esophageal carcinogenesis and the genes and products involved. The application of recent findings, used for early diagnosis, the existence of markers for prognosis, and the possibility of using new methods of treatment are discussed.Uma revolução no entendimento da gênese do câncer humano vem acontecendo, e sua natureza fundamentalmente genética foi reconhecida. Os cânceres gastrointestinais apresentam alta incidência e prognóstico reservado na maioria dos casos quando da sua apresentação em nosso meio. Espera-se que a biologia molecular traga novos caminhos para o diagnóstico e tratamento mais efetivos. No nosso trabalho, são abordados os aspectos atuais da carcinogênese colorretal, esofágica e gástrica, bem como os genes e seus sub-produtos (proteínas) envolvidos. As implicações clínicas destes novos conhecimentos, como as aplicações no diagnóstico precoce, a existência de marcadores prognósticos e a possibilidade de novos tratamentos, são discutidos.HCPA/FAMED/UFRGS2022-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article"A Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125713Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPAClinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125713/85369http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessF. Dillenburg, Carlos Moreira, Luis Fernando 2022-07-07T12:08:11Zoai:seer.ufrgs.br:article/125713Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-07-07T12:08:11Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv The Molecular biology of gastrointestinal tumors
Biologia molecular dos tumores do trato digestivo
title The Molecular biology of gastrointestinal tumors
spellingShingle The Molecular biology of gastrointestinal tumors
F. Dillenburg, Carlos
Biologia molecular
digestivo
gastrointestinais
tumores
carcinogênese
oncogenese
Molecular biology
digestive system
gastrointestinal system
tumors
carcinogenesis
title_short The Molecular biology of gastrointestinal tumors
title_full The Molecular biology of gastrointestinal tumors
title_fullStr The Molecular biology of gastrointestinal tumors
title_full_unstemmed The Molecular biology of gastrointestinal tumors
title_sort The Molecular biology of gastrointestinal tumors
author F. Dillenburg, Carlos
author_facet F. Dillenburg, Carlos
Moreira, Luis Fernando
author_role author
author2 Moreira, Luis Fernando
author2_role author
dc.contributor.author.fl_str_mv F. Dillenburg, Carlos
Moreira, Luis Fernando
dc.subject.por.fl_str_mv Biologia molecular
digestivo
gastrointestinais
tumores
carcinogênese
oncogenese
Molecular biology
digestive system
gastrointestinal system
tumors
carcinogenesis
topic Biologia molecular
digestivo
gastrointestinais
tumores
carcinogênese
oncogenese
Molecular biology
digestive system
gastrointestinal system
tumors
carcinogenesis
description Remarkable improvements in the understanding of the development of human cancer and of its genetic nature have been reported. At our services, we have observed that there is a high incidence of gastrointestinal tumors in our region and, also, that poor prognosis occurs due to patients presenting with advanced stages of the disease. In this sense, it is expected that molecular biology studies will bring new hope for more effective diagnostic and treatment methods. Consequently, it is our objective to address the current aspects on colorectal, gastric, and esophageal carcinogenesis and the genes and products involved. The application of recent findings, used for early diagnosis, the existence of markers for prognosis, and the possibility of using new methods of treatment are discussed.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article"
A Convite dos Editores
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125713
url https://seer.ufrgs.br/index.php/hcpa/article/view/125713
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125713/85369
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPA
Clinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
_version_ 1799767057419468800

Registros relacionados