Thyroid Hormones and Testicular Function

Detalhes bibliográficos
Autor(a) principal: Wajner, Simone Magagnin
Data de Publicação: 2008
Outros Autores: Wagner, Marcia Santos, Fernandes, Natália Sonego, Maia, Ana Luiza Silva
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/3090
Resumo: Thyroid hormones play an important role in the growth, development, and metabolism of mammalian tissues. The pro-hormone thyroxine (T4) is synthesized and secreted by the thyroid gland together with a small amount of the active hormone, triiodothyronine (T3). The iodothyronine deiodinases types 1 and 2 catalize the peripheral T4 to T3 conversion. To exert its biological effects T3 interact with specific membrane transporters and nuclear receptors, thus activating gene transcription. Classically, male gonads were considered to be unresponsive to thyroid hormones. Recent studies, however, have shown that thyroid hormones have a critical role in the male reproductive system, not only during development, but also in adult life. Hence, we review and discuss the most recent advances in our understanding of thyroid hormone effects in male gonadal function.
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spelling Thyroid Hormones and Testicular FunctionO Papel dos Hormônios Tireoidianos na Função Testicularhormônio tireoidianotireóidemetabolismofunção testicularpesquisa experimentalfisiopatologiaThyroid hormones play an important role in the growth, development, and metabolism of mammalian tissues. The pro-hormone thyroxine (T4) is synthesized and secreted by the thyroid gland together with a small amount of the active hormone, triiodothyronine (T3). The iodothyronine deiodinases types 1 and 2 catalize the peripheral T4 to T3 conversion. To exert its biological effects T3 interact with specific membrane transporters and nuclear receptors, thus activating gene transcription. Classically, male gonads were considered to be unresponsive to thyroid hormones. Recent studies, however, have shown that thyroid hormones have a critical role in the male reproductive system, not only during development, but also in adult life. Hence, we review and discuss the most recent advances in our understanding of thyroid hormone effects in male gonadal function.Os hormônios tireoidianos são essenciais para o crescimento, desenvolvimento e metabolismo. O pró-hormônio tiroxina (T4) é sintetizado e secretado pela glândula tireóide junto com uma pequena quantidade do hormônio ativo, a triiodotironina (T3). A conversão de T4 em T3 ocorre na periferia através da atividade das iodotironinas desiodases tipo 1 e tipo 2. Os efeitos biológicos dos hormônios tireoidianos são mediados pela interação do hormônio metabolicamente ativo (T3) com transportadores de membrana e receptores nucleares, resultando em ativação da transcrição gênica. Classicamente as gônadas eram consideradas refratárias aos hormônios tireoidianos. Estudos recentes, no entanto, têm demonstrado que o hormônio da tireóide desempenha um papel crítico no aparelho reprodutor, não somente durante o período de desenvolvimento, mas também na vida adulta. Neste artigo apresentamos uma revisão sobre o papel desempenhado pelos hormônios tireoidianos sobre a função testicular.HCPA/FAMED/UFRGS2008-05-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliados por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/3090Clinical & Biomedical Research; Vol. 28 No. 1 (2008): Revista HCPAClinical and Biomedical Research; v. 28 n. 1 (2008): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/3090/2292Wajner, Simone MagagninWagner, Marcia SantosFernandes, Natália SonegoMaia, Ana Luiza Silvainfo:eu-repo/semantics/openAccess2020-01-16T16:15:43Zoai:seer.ufrgs.br:article/3090Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T16:15:43Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Thyroid Hormones and Testicular Function
O Papel dos Hormônios Tireoidianos na Função Testicular
title Thyroid Hormones and Testicular Function
spellingShingle Thyroid Hormones and Testicular Function
Wajner, Simone Magagnin
hormônio tireoidiano
tireóide
metabolismo
função testicular
pesquisa experimental
fisiopatologia
title_short Thyroid Hormones and Testicular Function
title_full Thyroid Hormones and Testicular Function
title_fullStr Thyroid Hormones and Testicular Function
title_full_unstemmed Thyroid Hormones and Testicular Function
title_sort Thyroid Hormones and Testicular Function
author Wajner, Simone Magagnin
author_facet Wajner, Simone Magagnin
Wagner, Marcia Santos
Fernandes, Natália Sonego
Maia, Ana Luiza Silva
author_role author
author2 Wagner, Marcia Santos
Fernandes, Natália Sonego
Maia, Ana Luiza Silva
author2_role author
author
author
dc.contributor.author.fl_str_mv Wajner, Simone Magagnin
Wagner, Marcia Santos
Fernandes, Natália Sonego
Maia, Ana Luiza Silva
dc.subject.por.fl_str_mv hormônio tireoidiano
tireóide
metabolismo
função testicular
pesquisa experimental
fisiopatologia
topic hormônio tireoidiano
tireóide
metabolismo
função testicular
pesquisa experimental
fisiopatologia
description Thyroid hormones play an important role in the growth, development, and metabolism of mammalian tissues. The pro-hormone thyroxine (T4) is synthesized and secreted by the thyroid gland together with a small amount of the active hormone, triiodothyronine (T3). The iodothyronine deiodinases types 1 and 2 catalize the peripheral T4 to T3 conversion. To exert its biological effects T3 interact with specific membrane transporters and nuclear receptors, thus activating gene transcription. Classically, male gonads were considered to be unresponsive to thyroid hormones. Recent studies, however, have shown that thyroid hormones have a critical role in the male reproductive system, not only during development, but also in adult life. Hence, we review and discuss the most recent advances in our understanding of thyroid hormone effects in male gonadal function.
publishDate 2008
dc.date.none.fl_str_mv 2008-05-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliados por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/3090
url https://seer.ufrgs.br/index.php/hcpa/article/view/3090
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/3090/2292
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 28 No. 1 (2008): Revista HCPA
Clinical and Biomedical Research; v. 28 n. 1 (2008): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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