Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy : a case report and review of literature

• Autor(a) principal: Fernandes, Michel Ribeiro
• Data de Publicação: 2021
• Outros Autores: Ghezzi, Caroline Lorenzoni Almeida, Grezzana Filho, Tomáz de Jesus Maria, Feier, Flávia Heinz, Leipnitz, Ian, Chedid, Aljamir Duarte, Cerski, Carlos Thadeu Schmidt, Chedid, Márcio Fernandes, Kruel, Cleber Rosito Pinto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/229314
• topic: Neoplasias gastrointestinais; Tumores do estroma gastrointestinal; Procedimentos cirúrgicos de citorredução; Relatos de casos; Extra-gastrointestinal stromal tumor; Primary gastrointestinal stromal tumor of the liver; Cytoreductive surgery; Debulking surgery; Case report

BACKGROUND Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect. Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care. However, under specific circumstances, a cytoreductive approach may represent a therapeutic option. We describe herein the case of an 84-year-old woman who presented with a tender, protruding epigastric mass. Abdominal computed tomography scan revealed a large, heterogeneous mass located across segments III, IV, V, and VIII of the liver. The initial approach was transarterial embolization of the tumor, which elicited no appreciable response. Considering the large size and central location of the tumor and the advanced age of the patient, non-anatomic complete resection was indicated. Due to substantial intraoperative bleeding and hemodynamic instability, only a near-complete resection could be achieved. Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver. Considering the risk/benefit ratio for therapeutic options, debulking surgery may represent a strategy to control pain and prolong survival. CASE SUMMARY Here, we present a case report of a patient diagnosed with E-GIST primary of the liver, which was indicated a cytoreductive surgery and adjuvant therapy with imatinib. CONCLUSION E-GIST primary of the liver is a rare conditional, the treatment is with systemic therapy and total resection surgery. However, a cytoreductive surgery will be necessary when a complete resection is no possible.