Facial asymmetry and genetic ancestry in Latin American admixed populations

Detalhes bibliográficos
Autor(a) principal: Quinto Sanchez, Mirsha
Data de Publicação: 2015
Outros Autores: Adhikari, Kaustubh, Acunã Alonzo, Víctor, Cintas, Célia, Cerqueira, Caio Cesar Silva de, Ramallo, Virgínia, Castillo, Lucia, Farrera, Alodi, Jaramillo, Claudia, Arias, Williams, Fuentes, Macarena, Everardo, Paola, Avila, Francisco de, Gómez Valdés, Jorge A., Hunemeier, Tábita, Gibbon, Sahra, Gallo, Carla, Poletti, Giovanni, Rosique, Javier, Bortolini, Maria Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Bedoya, Gabriel, Ruiz-Linares, Andres, Gonzáles José, Rolando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/122629
Resumo: Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuais can be of help to characterize the impact of a genome's heterozygosity on the deveiopmental basis of both fl.uctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and ftuctuating asymmetry (FA), as well as correiations and multipie regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Resuits indicate that directional and FA are both signi:ficant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuais exhibit lower leveis of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare leveis of asymmetries on groups differing on socioeconomic leveis, as a proxy to estimate developmental noise.
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spelling Quinto Sanchez, MirshaAdhikari, KaustubhAcunã Alonzo, VíctorCintas, CéliaCerqueira, Caio Cesar Silva deRamallo, VirgíniaCastillo, LuciaFarrera, AlodiJaramillo, ClaudiaArias, WilliamsFuentes, MacarenaEverardo, PaolaAvila, Francisco deGómez Valdés, Jorge A.Hunemeier, TábitaGibbon, SahraGallo, CarlaPoletti, GiovanniRosique, JavierBortolini, Maria CátiraCanizales-Quinteros, SamuelRothhammer, FranciscoBedoya, GabrielRuiz-Linares, AndresGonzáles José, Rolando2015-08-20T02:33:06Z20150002-9483http://hdl.handle.net/10183/122629000966103Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuais can be of help to characterize the impact of a genome's heterozygosity on the deveiopmental basis of both fl.uctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and ftuctuating asymmetry (FA), as well as correiations and multipie regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Resuits indicate that directional and FA are both signi:ficant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuais exhibit lower leveis of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare leveis of asymmetries on groups differing on socioeconomic leveis, as a proxy to estimate developmental noise.application/pdfengAmerican journal of physical anthropology. Vol. 157, no. 1 (2015), p. 58-70Assimetria facialAncestralidadeAmérica LatinaFacial directional asymmetryFacial fluctuating asymmetryGenetic ancestryLatin AmericaGeometric morphometricsFacial asymmetry and genetic ancestry in Latin American admixed populationsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000966103.pdf000966103.pdfTexto completo (inglês)application/pdf10841382http://www.lume.ufrgs.br/bitstream/10183/122629/1/000966103.pdfd3e37b398300439607f9653ad803c5c8MD51TEXT000966103.pdf.txt000966103.pdf.txtExtracted Texttext/plain68941http://www.lume.ufrgs.br/bitstream/10183/122629/2/000966103.pdf.txt6f2d4c62759ec375ebb5053ea5e7bd82MD52THUMBNAIL000966103.pdf.jpg000966103.pdf.jpgGenerated Thumbnailimage/jpeg1933http://www.lume.ufrgs.br/bitstream/10183/122629/3/000966103.pdf.jpgc1d46608ed97af255e09edbbaf7dbcd4MD5310183/1226292018-10-09 08:06:34.787oai:www.lume.ufrgs.br:10183/122629Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-09T11:06:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Facial asymmetry and genetic ancestry in Latin American admixed populations
title Facial asymmetry and genetic ancestry in Latin American admixed populations
spellingShingle Facial asymmetry and genetic ancestry in Latin American admixed populations
Quinto Sanchez, Mirsha
Assimetria facial
Ancestralidade
América Latina
Facial directional asymmetry
Facial fluctuating asymmetry
Genetic ancestry
Latin America
Geometric morphometrics
title_short Facial asymmetry and genetic ancestry in Latin American admixed populations
title_full Facial asymmetry and genetic ancestry in Latin American admixed populations
title_fullStr Facial asymmetry and genetic ancestry in Latin American admixed populations
title_full_unstemmed Facial asymmetry and genetic ancestry in Latin American admixed populations
title_sort Facial asymmetry and genetic ancestry in Latin American admixed populations
author Quinto Sanchez, Mirsha
author_facet Quinto Sanchez, Mirsha
Adhikari, Kaustubh
Acunã Alonzo, Víctor
Cintas, Célia
Cerqueira, Caio Cesar Silva de
Ramallo, Virgínia
Castillo, Lucia
Farrera, Alodi
Jaramillo, Claudia
Arias, Williams
Fuentes, Macarena
Everardo, Paola
Avila, Francisco de
Gómez Valdés, Jorge A.
Hunemeier, Tábita
Gibbon, Sahra
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales-Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz-Linares, Andres
Gonzáles José, Rolando
author_role author
author2 Adhikari, Kaustubh
Acunã Alonzo, Víctor
Cintas, Célia
Cerqueira, Caio Cesar Silva de
Ramallo, Virgínia
Castillo, Lucia
Farrera, Alodi
Jaramillo, Claudia
Arias, Williams
Fuentes, Macarena
Everardo, Paola
Avila, Francisco de
Gómez Valdés, Jorge A.
Hunemeier, Tábita
Gibbon, Sahra
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales-Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz-Linares, Andres
Gonzáles José, Rolando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quinto Sanchez, Mirsha
Adhikari, Kaustubh
Acunã Alonzo, Víctor
Cintas, Célia
Cerqueira, Caio Cesar Silva de
Ramallo, Virgínia
Castillo, Lucia
Farrera, Alodi
Jaramillo, Claudia
Arias, Williams
Fuentes, Macarena
Everardo, Paola
Avila, Francisco de
Gómez Valdés, Jorge A.
Hunemeier, Tábita
Gibbon, Sahra
Gallo, Carla
Poletti, Giovanni
Rosique, Javier
Bortolini, Maria Cátira
Canizales-Quinteros, Samuel
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz-Linares, Andres
Gonzáles José, Rolando
dc.subject.por.fl_str_mv Assimetria facial
Ancestralidade
América Latina
topic Assimetria facial
Ancestralidade
América Latina
Facial directional asymmetry
Facial fluctuating asymmetry
Genetic ancestry
Latin America
Geometric morphometrics
dc.subject.eng.fl_str_mv Facial directional asymmetry
Facial fluctuating asymmetry
Genetic ancestry
Latin America
Geometric morphometrics
description Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuais can be of help to characterize the impact of a genome's heterozygosity on the deveiopmental basis of both fl.uctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and ftuctuating asymmetry (FA), as well as correiations and multipie regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Resuits indicate that directional and FA are both signi:ficant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuais exhibit lower leveis of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare leveis of asymmetries on groups differing on socioeconomic leveis, as a proxy to estimate developmental noise.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-08-20T02:33:06Z
dc.date.issued.fl_str_mv 2015
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.nrb.pt_BR.fl_str_mv 000966103
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv American journal of physical anthropology. Vol. 157, no. 1 (2015), p. 58-70
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