High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/30542 |
Resumo: | Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
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Antunes, Ana Lucia SouzaBonfanti, Jéssica WeisPerez, Leandro Reus RodriguesPinto, Camille Catani FerreiraFreitas, Ana Lucia Peixoto deMacedo, Alexandre JoséBarth, Afonso Luis2011-08-04T06:01:11Z20110074-0276http://hdl.handle.net/10183/30542000769038Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.application/pdfengMemórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Rio de Janeiro. Vol. 106, n. 1 (Feb. 2011), p. 51-55Staphylococcus aureusBiofilmesResistência à vancomicinaCateterismo venoso centralInfecções bacterianasBiofilmVancomycinStaphylococcus sppHigh vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous cathetersinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000769038.pdf000769038.pdfTexto completo (inglês)application/pdf342247http://www.lume.ufrgs.br/bitstream/10183/30542/1/000769038.pdfe00f24cb6f6b918e10c30bd8dd8dfda9MD51TEXT000769038.pdf.txt000769038.pdf.txtExtracted Texttext/plain25770http://www.lume.ufrgs.br/bitstream/10183/30542/2/000769038.pdf.txta6fadce5753fceb1de6176efe36c3ad4MD52THUMBNAIL000769038.pdf.jpg000769038.pdf.jpgGenerated Thumbnailimage/jpeg2024http://www.lume.ufrgs.br/bitstream/10183/30542/3/000769038.pdf.jpg64b0111abbb310b60c86508e589319c0MD5310183/305422018-10-15 09:05:42.54oai:www.lume.ufrgs.br:10183/30542Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-15T12:05:42Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
title |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
spellingShingle |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters Antunes, Ana Lucia Souza Staphylococcus aureus Biofilmes Resistência à vancomicina Cateterismo venoso central Infecções bacterianas Biofilm Vancomycin Staphylococcus spp |
title_short |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
title_full |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
title_fullStr |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
title_full_unstemmed |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
title_sort |
High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
author |
Antunes, Ana Lucia Souza |
author_facet |
Antunes, Ana Lucia Souza Bonfanti, Jéssica Weis Perez, Leandro Reus Rodrigues Pinto, Camille Catani Ferreira Freitas, Ana Lucia Peixoto de Macedo, Alexandre José Barth, Afonso Luis |
author_role |
author |
author2 |
Bonfanti, Jéssica Weis Perez, Leandro Reus Rodrigues Pinto, Camille Catani Ferreira Freitas, Ana Lucia Peixoto de Macedo, Alexandre José Barth, Afonso Luis |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes, Ana Lucia Souza Bonfanti, Jéssica Weis Perez, Leandro Reus Rodrigues Pinto, Camille Catani Ferreira Freitas, Ana Lucia Peixoto de Macedo, Alexandre José Barth, Afonso Luis |
dc.subject.por.fl_str_mv |
Staphylococcus aureus Biofilmes Resistência à vancomicina Cateterismo venoso central Infecções bacterianas |
topic |
Staphylococcus aureus Biofilmes Resistência à vancomicina Cateterismo venoso central Infecções bacterianas Biofilm Vancomycin Staphylococcus spp |
dc.subject.eng.fl_str_mv |
Biofilm Vancomycin Staphylococcus spp |
description |
Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
publishDate |
2011 |
dc.date.accessioned.fl_str_mv |
2011-08-04T06:01:11Z |
dc.date.issued.fl_str_mv |
2011 |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
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http://hdl.handle.net/10183/30542 |
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0074-0276 |
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000769038 |
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http://hdl.handle.net/10183/30542 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Rio de Janeiro. Vol. 106, n. 1 (Feb. 2011), p. 51-55 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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