HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/230489 |
Resumo: | Introduction and objectives: Currently, there are limited data on the epidemiology and disease characteristics of patients with chronic hepatitis C (CHC) in Latin America. The primary objective of this study was to evaluate demographic and disease characteristics of patients with CHC in Latin America. Patients and methods: HEPLA was a non-interventional, multicenter study ofthe epidemiology and disease characteristics of patients with CHC in Argentina, Brazil, Chile, Colombia, and Mexico. Results: Of the 817 included patients, the median age was 58 years, 53.9% were female, and 39.3% had cirrhosis. Overall, 41.2% were treatment naive, 49.8% were treatment experienced, and 8.9% were currently undergoing treatment. In patients with available data, genotype 1b accounted for 41.6% of infections, followed by genotype 1a (29.9%) and genotype 3 (11.3%). Probable mode of infection was transfusion in 46.8% of patients. Liver-related comorbidities were present in 26.4% of patients and non-liver-related comorbidities were present in 72.3%. Most patients (71.8%) received concomitant medications, with proton-pump inhibitors (20.8%) being the most commonly reported. Conclusions: At the time the HEPLA study was carried out, the data from this cross-section of patients in Latin America showed that the CHC population has variation in disease and viral characteristics, with a minority of patients receiving treatment and many patients having advanced disease. Increased awareness and access to treatment are necessary in Latin America in order to meet the goal of hepatitis C virus elimination by 2030. |
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Viola, LuisMarciano, SebastiánColombato, LuisCoelho, HenriqueCheinquer, HugoBugarin, GabrielaTatsch, Fernando FranciosiCarvalho Filho, Roberto J.Roblero, Juan P.Varoni, AdrianaHolguin, JaimeTorres Ibarra, Maria R.Pérez Ríos, Alma M.2021-10-05T04:26:47Z20201665-2681http://hdl.handle.net/10183/230489001131194Introduction and objectives: Currently, there are limited data on the epidemiology and disease characteristics of patients with chronic hepatitis C (CHC) in Latin America. The primary objective of this study was to evaluate demographic and disease characteristics of patients with CHC in Latin America. Patients and methods: HEPLA was a non-interventional, multicenter study ofthe epidemiology and disease characteristics of patients with CHC in Argentina, Brazil, Chile, Colombia, and Mexico. Results: Of the 817 included patients, the median age was 58 years, 53.9% were female, and 39.3% had cirrhosis. Overall, 41.2% were treatment naive, 49.8% were treatment experienced, and 8.9% were currently undergoing treatment. In patients with available data, genotype 1b accounted for 41.6% of infections, followed by genotype 1a (29.9%) and genotype 3 (11.3%). Probable mode of infection was transfusion in 46.8% of patients. Liver-related comorbidities were present in 26.4% of patients and non-liver-related comorbidities were present in 72.3%. Most patients (71.8%) received concomitant medications, with proton-pump inhibitors (20.8%) being the most commonly reported. Conclusions: At the time the HEPLA study was carried out, the data from this cross-section of patients in Latin America showed that the CHC population has variation in disease and viral characteristics, with a minority of patients receiving treatment and many patients having advanced disease. Increased awareness and access to treatment are necessary in Latin America in order to meet the goal of hepatitis C virus elimination by 2030.application/pdfengAnnals of hepatology. México. Vol. 19 (2021), p. 161-165.Hepatite CEpidemiologiaEstudo observacionalAmérica LatinaHCVLATAMEpidemiologyObservational studyHEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin AmericaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001131194.pdf.txt001131194.pdf.txtExtracted Texttext/plain28821http://www.lume.ufrgs.br/bitstream/10183/230489/2/001131194.pdf.txt2a446fb0a751e4cae6e05e914b06653eMD52ORIGINAL001131194.pdfTexto completo (inglês)application/pdf417134http://www.lume.ufrgs.br/bitstream/10183/230489/1/001131194.pdf5196651568191f3a682a9f7d18c39d9fMD5110183/2304892021-11-20 06:20:58.858326oai:www.lume.ufrgs.br:10183/230489Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T08:20:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
title |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
spellingShingle |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America Viola, Luis Hepatite C Epidemiologia Estudo observacional América Latina HCV LATAM Epidemiology Observational study |
title_short |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
title_full |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
title_fullStr |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
title_full_unstemmed |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
title_sort |
HEPLA : a multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America |
author |
Viola, Luis |
author_facet |
Viola, Luis Marciano, Sebastián Colombato, Luis Coelho, Henrique Cheinquer, Hugo Bugarin, Gabriela Tatsch, Fernando Franciosi Carvalho Filho, Roberto J. Roblero, Juan P. Varoni, Adriana Holguin, Jaime Torres Ibarra, Maria R. Pérez Ríos, Alma M. |
author_role |
author |
author2 |
Marciano, Sebastián Colombato, Luis Coelho, Henrique Cheinquer, Hugo Bugarin, Gabriela Tatsch, Fernando Franciosi Carvalho Filho, Roberto J. Roblero, Juan P. Varoni, Adriana Holguin, Jaime Torres Ibarra, Maria R. Pérez Ríos, Alma M. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Viola, Luis Marciano, Sebastián Colombato, Luis Coelho, Henrique Cheinquer, Hugo Bugarin, Gabriela Tatsch, Fernando Franciosi Carvalho Filho, Roberto J. Roblero, Juan P. Varoni, Adriana Holguin, Jaime Torres Ibarra, Maria R. Pérez Ríos, Alma M. |
dc.subject.por.fl_str_mv |
Hepatite C Epidemiologia Estudo observacional América Latina |
topic |
Hepatite C Epidemiologia Estudo observacional América Latina HCV LATAM Epidemiology Observational study |
dc.subject.eng.fl_str_mv |
HCV LATAM Epidemiology Observational study |
description |
Introduction and objectives: Currently, there are limited data on the epidemiology and disease characteristics of patients with chronic hepatitis C (CHC) in Latin America. The primary objective of this study was to evaluate demographic and disease characteristics of patients with CHC in Latin America. Patients and methods: HEPLA was a non-interventional, multicenter study ofthe epidemiology and disease characteristics of patients with CHC in Argentina, Brazil, Chile, Colombia, and Mexico. Results: Of the 817 included patients, the median age was 58 years, 53.9% were female, and 39.3% had cirrhosis. Overall, 41.2% were treatment naive, 49.8% were treatment experienced, and 8.9% were currently undergoing treatment. In patients with available data, genotype 1b accounted for 41.6% of infections, followed by genotype 1a (29.9%) and genotype 3 (11.3%). Probable mode of infection was transfusion in 46.8% of patients. Liver-related comorbidities were present in 26.4% of patients and non-liver-related comorbidities were present in 72.3%. Most patients (71.8%) received concomitant medications, with proton-pump inhibitors (20.8%) being the most commonly reported. Conclusions: At the time the HEPLA study was carried out, the data from this cross-section of patients in Latin America showed that the CHC population has variation in disease and viral characteristics, with a minority of patients receiving treatment and many patients having advanced disease. Increased awareness and access to treatment are necessary in Latin America in order to meet the goal of hepatitis C virus elimination by 2030. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
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2021-10-05T04:26:47Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/230489 |
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1665-2681 |
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001131194 |
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dc.language.iso.fl_str_mv |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Annals of hepatology. México. Vol. 19 (2021), p. 161-165. |
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