Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/216643 |
Resumo: | Currently, magnetic nanoparticles are widely studied with regard to their application in cancer treatment. This study aims to show a straightforward strategy for the production of Fe3O4 nanoparticles (NPs) with biocompatible surface modifications with polycaprolactone (PCL) for biomedical purposes. The effects of the polymer coating on the properties of magnetite were evaluated. Crystallinity, morphology, composition, hydrodynamic size and magnetic properties of the produced nanoparticles were analysed via X-ray diffractometry (XRD), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Vibrating Sample Magnetometry (VSM), respectively. The proposed method produced nanoparticles of magnetite with an average size between 9 and 11 nm, with spherical morphology and superparamagnetic properties. Magnetization values were not compromised even when the highest amount of polymer was used in the surface modification. On the other hand, the coating resulted in the decrease of the hydrodynamic size of the composites, indicating greater colloidal stability when the polymer was present. The obtained nanoparticles showed maintenance of significant superparamagneticbehavior, even in the presence of PCL on their surface. This phenomenon would allow for their application as a further optimized vector in hyperthermia cancer treatment, controlled drug delivery and resonance imaging. |
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Vieira, Jaqueline LeiteMaurmann, NatashaVenturini Junior, JanioPranke, Patricia Helena LucasBergmann, Carlos Perez2020-12-17T04:10:14Z20202372-0964http://hdl.handle.net/10183/216643001119342Currently, magnetic nanoparticles are widely studied with regard to their application in cancer treatment. This study aims to show a straightforward strategy for the production of Fe3O4 nanoparticles (NPs) with biocompatible surface modifications with polycaprolactone (PCL) for biomedical purposes. The effects of the polymer coating on the properties of magnetite were evaluated. Crystallinity, morphology, composition, hydrodynamic size and magnetic properties of the produced nanoparticles were analysed via X-ray diffractometry (XRD), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Vibrating Sample Magnetometry (VSM), respectively. The proposed method produced nanoparticles of magnetite with an average size between 9 and 11 nm, with spherical morphology and superparamagnetic properties. Magnetization values were not compromised even when the highest amount of polymer was used in the surface modification. On the other hand, the coating resulted in the decrease of the hydrodynamic size of the composites, indicating greater colloidal stability when the polymer was present. The obtained nanoparticles showed maintenance of significant superparamagneticbehavior, even in the presence of PCL on their surface. This phenomenon would allow for their application as a further optimized vector in hyperthermia cancer treatment, controlled drug delivery and resonance imaging.application/pdfengSOJ Materials Science & Engineering [recurso eletrônico]. Normal-Illinois, USA: Symbiosis. Vol. 7, no. 1 (2020), 6 p.NanopartículasMagnetitaNeoplasiasFebreNanoparticlesMagnetitePCLCancerHyperthermiaProduction and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applicationsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001119342.pdf.txt001119342.pdf.txtExtracted Texttext/plain27223http://www.lume.ufrgs.br/bitstream/10183/216643/2/001119342.pdf.txt783c8f48d8d147db468a22265ddc90d0MD52ORIGINAL001119342.pdfTexto completo (inglês)application/pdf507997http://www.lume.ufrgs.br/bitstream/10183/216643/1/001119342.pdf2b9e7e2c2119582b3278cb725b4f8363MD5110183/2166432021-03-09 04:42:06.37979oai:www.lume.ufrgs.br:10183/216643Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2021-03-09T07:42:06Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
title |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
spellingShingle |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications Vieira, Jaqueline Leite Nanopartículas Magnetita Neoplasias Febre Nanoparticles Magnetite PCL Cancer Hyperthermia |
title_short |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
title_full |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
title_fullStr |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
title_full_unstemmed |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
title_sort |
Production and characterization of magnetic Fe3O4 nanoparticles coated with PCL for biomedical applications |
author |
Vieira, Jaqueline Leite |
author_facet |
Vieira, Jaqueline Leite Maurmann, Natasha Venturini Junior, Janio Pranke, Patricia Helena Lucas Bergmann, Carlos Perez |
author_role |
author |
author2 |
Maurmann, Natasha Venturini Junior, Janio Pranke, Patricia Helena Lucas Bergmann, Carlos Perez |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vieira, Jaqueline Leite Maurmann, Natasha Venturini Junior, Janio Pranke, Patricia Helena Lucas Bergmann, Carlos Perez |
dc.subject.por.fl_str_mv |
Nanopartículas Magnetita Neoplasias Febre |
topic |
Nanopartículas Magnetita Neoplasias Febre Nanoparticles Magnetite PCL Cancer Hyperthermia |
dc.subject.eng.fl_str_mv |
Nanoparticles Magnetite PCL Cancer Hyperthermia |
description |
Currently, magnetic nanoparticles are widely studied with regard to their application in cancer treatment. This study aims to show a straightforward strategy for the production of Fe3O4 nanoparticles (NPs) with biocompatible surface modifications with polycaprolactone (PCL) for biomedical purposes. The effects of the polymer coating on the properties of magnetite were evaluated. Crystallinity, morphology, composition, hydrodynamic size and magnetic properties of the produced nanoparticles were analysed via X-ray diffractometry (XRD), Transmission Electron Microscopy (TEM), Fourier-Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS) and Vibrating Sample Magnetometry (VSM), respectively. The proposed method produced nanoparticles of magnetite with an average size between 9 and 11 nm, with spherical morphology and superparamagnetic properties. Magnetization values were not compromised even when the highest amount of polymer was used in the surface modification. On the other hand, the coating resulted in the decrease of the hydrodynamic size of the composites, indicating greater colloidal stability when the polymer was present. The obtained nanoparticles showed maintenance of significant superparamagneticbehavior, even in the presence of PCL on their surface. This phenomenon would allow for their application as a further optimized vector in hyperthermia cancer treatment, controlled drug delivery and resonance imaging. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-12-17T04:10:14Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/216643 |
dc.identifier.issn.pt_BR.fl_str_mv |
2372-0964 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001119342 |
identifier_str_mv |
2372-0964 001119342 |
url |
http://hdl.handle.net/10183/216643 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
SOJ Materials Science & Engineering [recurso eletrônico]. Normal-Illinois, USA: Symbiosis. Vol. 7, no. 1 (2020), 6 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Repositório Institucional da UFRGS |
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Repositório Institucional da UFRGS |
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Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
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