Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/199387 |
Resumo: | Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells. |
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Peres, Letícia PangendlerCartell, Andre da SilvaCestari, Tania FerreiraOliveira, Fabiana Bazanella deMazzotti, Nicolle Gollo2019-09-18T03:44:26Z20180365-0596http://hdl.handle.net/10183/199387001101647Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.application/pdfengAnais brasileiros de dermatologia. Vol. 93, no. 3 (2018), p. 368-372PsoríasePruridoMastócitosEstudos transversaisMast cellsPruritusPsoriasisDensity of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001101647.pdf.txt001101647.pdf.txtExtracted Texttext/plain23659http://www.lume.ufrgs.br/bitstream/10183/199387/2/001101647.pdf.txt97c05648683d4749711529b55dd84deaMD52ORIGINAL001101647.pdfTexto completo (inglês)application/pdf381837http://www.lume.ufrgs.br/bitstream/10183/199387/1/001101647.pdf7ba13c30dd02fc2d4cab91d3791aa13eMD5110183/1993872019-09-19 03:44:13.921781oai:www.lume.ufrgs.br:10183/199387Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-19T06:44:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
title |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
spellingShingle |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study Peres, Letícia Pangendler Psoríase Prurido Mastócitos Estudos transversais Mast cells Pruritus Psoriasis |
title_short |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
title_full |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
title_fullStr |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
title_full_unstemmed |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
title_sort |
Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study |
author |
Peres, Letícia Pangendler |
author_facet |
Peres, Letícia Pangendler Cartell, Andre da Silva Cestari, Tania Ferreira Oliveira, Fabiana Bazanella de Mazzotti, Nicolle Gollo |
author_role |
author |
author2 |
Cartell, Andre da Silva Cestari, Tania Ferreira Oliveira, Fabiana Bazanella de Mazzotti, Nicolle Gollo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Peres, Letícia Pangendler Cartell, Andre da Silva Cestari, Tania Ferreira Oliveira, Fabiana Bazanella de Mazzotti, Nicolle Gollo |
dc.subject.por.fl_str_mv |
Psoríase Prurido Mastócitos Estudos transversais |
topic |
Psoríase Prurido Mastócitos Estudos transversais Mast cells Pruritus Psoriasis |
dc.subject.eng.fl_str_mv |
Mast cells Pruritus Psoriasis |
description |
Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
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http://hdl.handle.net/10183/199387 |
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Anais brasileiros de dermatologia. Vol. 93, no. 3 (2018), p. 368-372 |
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