Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study

Detalhes bibliográficos
Autor(a) principal: Peres, Letícia Pangendler
Data de Publicação: 2018
Outros Autores: Cartell, Andre da Silva, Cestari, Tania Ferreira, Oliveira, Fabiana Bazanella de, Mazzotti, Nicolle Gollo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/199387
Resumo: Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.
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spelling Peres, Letícia PangendlerCartell, Andre da SilvaCestari, Tania FerreiraOliveira, Fabiana Bazanella deMazzotti, Nicolle Gollo2019-09-18T03:44:26Z20180365-0596http://hdl.handle.net/10183/199387001101647Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.application/pdfengAnais brasileiros de dermatologia. Vol. 93, no. 3 (2018), p. 368-372PsoríasePruridoMastócitosEstudos transversaisMast cellsPruritusPsoriasisDensity of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional studyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001101647.pdf.txt001101647.pdf.txtExtracted Texttext/plain23659http://www.lume.ufrgs.br/bitstream/10183/199387/2/001101647.pdf.txt97c05648683d4749711529b55dd84deaMD52ORIGINAL001101647.pdfTexto completo (inglês)application/pdf381837http://www.lume.ufrgs.br/bitstream/10183/199387/1/001101647.pdf7ba13c30dd02fc2d4cab91d3791aa13eMD5110183/1993872019-09-19 03:44:13.921781oai:www.lume.ufrgs.br:10183/199387Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-09-19T06:44:13Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
title Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
spellingShingle Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
Peres, Letícia Pangendler
Psoríase
Prurido
Mastócitos
Estudos transversais
Mast cells
Pruritus
Psoriasis
title_short Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
title_full Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
title_fullStr Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
title_full_unstemmed Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
title_sort Density of mast cells and intensity of pruritus in psoriasis vulgaris : a cross sectional study
author Peres, Letícia Pangendler
author_facet Peres, Letícia Pangendler
Cartell, Andre da Silva
Cestari, Tania Ferreira
Oliveira, Fabiana Bazanella de
Mazzotti, Nicolle Gollo
author_role author
author2 Cartell, Andre da Silva
Cestari, Tania Ferreira
Oliveira, Fabiana Bazanella de
Mazzotti, Nicolle Gollo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Peres, Letícia Pangendler
Cartell, Andre da Silva
Cestari, Tania Ferreira
Oliveira, Fabiana Bazanella de
Mazzotti, Nicolle Gollo
dc.subject.por.fl_str_mv Psoríase
Prurido
Mastócitos
Estudos transversais
topic Psoríase
Prurido
Mastócitos
Estudos transversais
Mast cells
Pruritus
Psoriasis
dc.subject.eng.fl_str_mv Mast cells
Pruritus
Psoriasis
description Background: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-tocontrol symptom. The mediators involved in psoriatic pruritus have not been fully established. Objective: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. Methods: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed. A questionnaire was administered to obtain clinical information and the Dermatology Life Quality Index. Pruritus was assessed using a visual analog scale and skin biopsies were performed for staining with Giemsa and Immunohistochemistry with C-Kit. Results: Pruritus was observed in 91.3% of our patients. Median VAS was 6 (p25-75: 2-8). The immunohistochemical method revealed a mean of 11.32 mast cells/field and Giemsa staining revealed a mean of 6.72 mast cells/field. There was no correlation between the intensity of pruritus and mast cell count, neither in Immunohistochemistry (p = 0.15; rho = -0.27) nor in Giemsa (p = 0.16; rho = -0.27). Pruritus did not impact on the Dermatology Life Quality Index (p = 0.51; rho = -0.13). Study limitations: The small sample size may be considered the main limitation of our study. Conclusions: Although mast cells are mediators of pruritus in many cutaneous diseases, our findings support that psoriatic pruritus is a complex disorder with multifactorial, complex pathophysiology, involving pruritogenic mediators others than mast cells.
publishDate 2018
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dc.relation.ispartof.pt_BR.fl_str_mv Anais brasileiros de dermatologia. Vol. 93, no. 3 (2018), p. 368-372
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