Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease =Risco de apneia obstrutiva do sono detectado pelo Questionário de Berlim está associado com doença arterial coronariana

• Autor(a) principal: Massierer, Daniela
• Data de Publicação: 2012
• Outros Autores: Martinez, Denis, Fuchs, Sandra Cristina Pereira Costa, Pellin, Paulo Peroni, Garcia, Márcio Severo, Zacharias, Ana Luisa, Antunes, Isadora Fregonese, Wainstein, Marco Vugman, Moreira, Leila Beltrami, Ribeiro, Jorge Pinto, Fuchs, Flávio Danni
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/95254
• topic: Apneia obstrutiva do sono; Doença da artéria coronariana; Inquéritos e questionários

Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis ≥ 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.