Changes in physical function over time in rheumatoid arthritis patients : a cohort study

Detalhes bibliográficos
Autor(a) principal: Espírito Santo, Rafaela Cavalheiro do
Data de Publicação: 2023
Outros Autores: Baker, Joshua Frederick, Santos, Leonardo Peterson dos, Silva, Jordana Miranda de Souza, Filippin, Lidiane Isabel, Portes, Juliana Katarina Schoer, Brenol, Claiton Viegas, Chakr, Rafael Mendonça da Silva, Xavier, Ricardo Machado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/259796
Resumo: Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function.
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spelling Espírito Santo, Rafaela Cavalheiro doBaker, Joshua FrederickSantos, Leonardo Peterson dosSilva, Jordana Miranda de SouzaFilippin, Lidiane IsabelPortes, Juliana Katarina SchoerBrenol, Claiton ViegasChakr, Rafael Mendonça da SilvaXavier, Ricardo Machado2023-07-04T03:48:52Z20231932-6203http://hdl.handle.net/10183/259796001169632Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function.application/pdfengPloS one. San Francisco. Vol. 18, no. 1 (Jan. 2023), e0280846, 16 p.Artrite reumatóideEstado funcionalChanges in physical function over time in rheumatoid arthritis patients : a cohort studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169632.pdf.txt001169632.pdf.txtExtracted Texttext/plain49574http://www.lume.ufrgs.br/bitstream/10183/259796/2/001169632.pdf.txt4ccf13ba27a5484133845eea673eb101MD52ORIGINAL001169632.pdfTexto completo (inglês)application/pdf1200912http://www.lume.ufrgs.br/bitstream/10183/259796/1/001169632.pdfa682db14fce4ec25c6be90cfa6289a0bMD5110183/2597962023-09-24 03:36:58.650981oai:www.lume.ufrgs.br:10183/259796Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:36:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Changes in physical function over time in rheumatoid arthritis patients : a cohort study
title Changes in physical function over time in rheumatoid arthritis patients : a cohort study
spellingShingle Changes in physical function over time in rheumatoid arthritis patients : a cohort study
Espírito Santo, Rafaela Cavalheiro do
Artrite reumatóide
Estado funcional
title_short Changes in physical function over time in rheumatoid arthritis patients : a cohort study
title_full Changes in physical function over time in rheumatoid arthritis patients : a cohort study
title_fullStr Changes in physical function over time in rheumatoid arthritis patients : a cohort study
title_full_unstemmed Changes in physical function over time in rheumatoid arthritis patients : a cohort study
title_sort Changes in physical function over time in rheumatoid arthritis patients : a cohort study
author Espírito Santo, Rafaela Cavalheiro do
author_facet Espírito Santo, Rafaela Cavalheiro do
Baker, Joshua Frederick
Santos, Leonardo Peterson dos
Silva, Jordana Miranda de Souza
Filippin, Lidiane Isabel
Portes, Juliana Katarina Schoer
Brenol, Claiton Viegas
Chakr, Rafael Mendonça da Silva
Xavier, Ricardo Machado
author_role author
author2 Baker, Joshua Frederick
Santos, Leonardo Peterson dos
Silva, Jordana Miranda de Souza
Filippin, Lidiane Isabel
Portes, Juliana Katarina Schoer
Brenol, Claiton Viegas
Chakr, Rafael Mendonça da Silva
Xavier, Ricardo Machado
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Espírito Santo, Rafaela Cavalheiro do
Baker, Joshua Frederick
Santos, Leonardo Peterson dos
Silva, Jordana Miranda de Souza
Filippin, Lidiane Isabel
Portes, Juliana Katarina Schoer
Brenol, Claiton Viegas
Chakr, Rafael Mendonça da Silva
Xavier, Ricardo Machado
dc.subject.por.fl_str_mv Artrite reumatóide
Estado funcional
topic Artrite reumatóide
Estado funcional
description Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function.
publishDate 2023
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dc.relation.ispartof.pt_BR.fl_str_mv PloS one. San Francisco. Vol. 18, no. 1 (Jan. 2023), e0280846, 16 p.
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