Changes in physical function over time in rheumatoid arthritis patients : a cohort study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/259796 |
Resumo: | Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function. |
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Espírito Santo, Rafaela Cavalheiro doBaker, Joshua FrederickSantos, Leonardo Peterson dosSilva, Jordana Miranda de SouzaFilippin, Lidiane IsabelPortes, Juliana Katarina SchoerBrenol, Claiton ViegasChakr, Rafael Mendonça da SilvaXavier, Ricardo Machado2023-07-04T03:48:52Z20231932-6203http://hdl.handle.net/10183/259796001169632Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function.application/pdfengPloS one. San Francisco. Vol. 18, no. 1 (Jan. 2023), e0280846, 16 p.Artrite reumatóideEstado funcionalChanges in physical function over time in rheumatoid arthritis patients : a cohort studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169632.pdf.txt001169632.pdf.txtExtracted Texttext/plain49574http://www.lume.ufrgs.br/bitstream/10183/259796/2/001169632.pdf.txt4ccf13ba27a5484133845eea673eb101MD52ORIGINAL001169632.pdfTexto completo (inglês)application/pdf1200912http://www.lume.ufrgs.br/bitstream/10183/259796/1/001169632.pdfa682db14fce4ec25c6be90cfa6289a0bMD5110183/2597962023-09-24 03:36:58.650981oai:www.lume.ufrgs.br:10183/259796Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:36:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
title |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
spellingShingle |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study Espírito Santo, Rafaela Cavalheiro do Artrite reumatóide Estado funcional |
title_short |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
title_full |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
title_fullStr |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
title_full_unstemmed |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
title_sort |
Changes in physical function over time in rheumatoid arthritis patients : a cohort study |
author |
Espírito Santo, Rafaela Cavalheiro do |
author_facet |
Espírito Santo, Rafaela Cavalheiro do Baker, Joshua Frederick Santos, Leonardo Peterson dos Silva, Jordana Miranda de Souza Filippin, Lidiane Isabel Portes, Juliana Katarina Schoer Brenol, Claiton Viegas Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
author_role |
author |
author2 |
Baker, Joshua Frederick Santos, Leonardo Peterson dos Silva, Jordana Miranda de Souza Filippin, Lidiane Isabel Portes, Juliana Katarina Schoer Brenol, Claiton Viegas Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Espírito Santo, Rafaela Cavalheiro do Baker, Joshua Frederick Santos, Leonardo Peterson dos Silva, Jordana Miranda de Souza Filippin, Lidiane Isabel Portes, Juliana Katarina Schoer Brenol, Claiton Viegas Chakr, Rafael Mendonça da Silva Xavier, Ricardo Machado |
dc.subject.por.fl_str_mv |
Artrite reumatóide Estado funcional |
topic |
Artrite reumatóide Estado funcional |
description |
Introduction Self-reported disability is potentially influenced by many factors in patients with rheumatoid arthritis (RA). In this sense, we evaluated the association between self-reported disability and (1) clinical features, (2) muscle strength and (3) physical performance over time among patients with RA from two distinct patient cohorts. Materials and methods Two independent prospective RA cohorts were analyzed. The Health Assessment Questionnaire (HAQ), Disease Activity Score in 28 Joints (DAS28), handgrip test, chair stand test, timed-up-and-go (TUG) test and Short Physical Performance Battery (SPPB) were performed at baseline and in follow-up. T test for independent samples, Mann-Whitney U test, Spearman correlation coefficients and linear regression with generalized estimating equations were performed to assess associations between individual constructs at baseline and over time. Results A total of 205 total RA patients were included [North American Cohort (n = 115); Brazilian Cohort (n = 90)]. At enrollment, Brazilian men had better HAQ than North American men (p<0.001). Brazilian patients overall had lower muscle strength than North American patients (p<0.05). HAQ was associated with DAS28, handgrip test, chair stand test, TUG and SPPB (p<0.001) in both cohorts. Worsening of the DAS28 and chair stand test were each associated with worsening in HAQ in longitudinal analysis over time. Worsening of handgrip was also associated in with worsening HAQ in both cohorts (p<0.05). A worse TUG test was associated with worsening in HAQ in Brazilian cohort (p<0.05) and a worse SPPB was associated with worsening in HAQ in North American cohort (p<0.05). Conclusion Greater disability measured by HAQ is closely associated with disease activity, pain, muscle strength, and physical performance among RA. Worsening in self-reported disability correlate with worsening clinical factors including objectively-observed physical function. |
publishDate |
2023 |
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2023-07-04T03:48:52Z |
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2023 |
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Estrangeiro info:eu-repo/semantics/article |
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1932-6203 |
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001169632 |
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http://hdl.handle.net/10183/259796 |
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PloS one. San Francisco. Vol. 18, no. 1 (Jan. 2023), e0280846, 16 p. |
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