Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/225515 |
Resumo: | In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation. Additionally, potential rewarding/aversion and anxiety effects induced by caffeine were evaluated by conditioning place preference or open field, respectively. Caffeine administration was able to attenuate weak fear memories in a standard memory reconsolidation protocol; however, periodical memory reactivation under caffeine effect was necessary to attenuate strong and remote memories. Moreover, caffeine promoted conditioned place preference and anxiolytic-like behavior, suggesting that caffeine weakens the initial learning during reactivation through counterconditioning mechanisms. Thus, our study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory. It brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders. |
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Correa, Lizeth Katherine PedrazaSierra Ordoñez, Rodrigo AlejandroAlves, Fernanda Nogueira LotzAlvares, Lucas de Oliveira2021-08-11T04:46:57Z20182045-2322http://hdl.handle.net/10183/225515001067586In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation. Additionally, potential rewarding/aversion and anxiety effects induced by caffeine were evaluated by conditioning place preference or open field, respectively. Caffeine administration was able to attenuate weak fear memories in a standard memory reconsolidation protocol; however, periodical memory reactivation under caffeine effect was necessary to attenuate strong and remote memories. Moreover, caffeine promoted conditioned place preference and anxiolytic-like behavior, suggesting that caffeine weakens the initial learning during reactivation through counterconditioning mechanisms. Thus, our study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory. It brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders.application/pdfengScientific reports. London. Vol. 8, (Sept. 2018), 7260, 1-11p.MemóriaCafeínaMedoRatosPeriodical reactivation under the effect of caffeine attenuates fear memory expression in ratsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001067586.pdf.txt001067586.pdf.txtExtracted Texttext/plain56069http://www.lume.ufrgs.br/bitstream/10183/225515/2/001067586.pdf.txt896220a8b97c9871a51f239329648c8aMD52ORIGINAL001067586.pdfTexto completo (inglês)application/pdf1435083http://www.lume.ufrgs.br/bitstream/10183/225515/1/001067586.pdf55a3bd2ee90bbd611f281f9a741c1645MD5110183/2255152021-08-18 04:29:33.356564oai:www.lume.ufrgs.br:10183/225515Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T07:29:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
title |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
spellingShingle |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats Correa, Lizeth Katherine Pedraza Memória Cafeína Medo Ratos |
title_short |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
title_full |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
title_fullStr |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
title_full_unstemmed |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
title_sort |
Periodical reactivation under the effect of caffeine attenuates fear memory expression in rats |
author |
Correa, Lizeth Katherine Pedraza |
author_facet |
Correa, Lizeth Katherine Pedraza Sierra Ordoñez, Rodrigo Alejandro Alves, Fernanda Nogueira Lotz Alvares, Lucas de Oliveira |
author_role |
author |
author2 |
Sierra Ordoñez, Rodrigo Alejandro Alves, Fernanda Nogueira Lotz Alvares, Lucas de Oliveira |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Correa, Lizeth Katherine Pedraza Sierra Ordoñez, Rodrigo Alejandro Alves, Fernanda Nogueira Lotz Alvares, Lucas de Oliveira |
dc.subject.por.fl_str_mv |
Memória Cafeína Medo Ratos |
topic |
Memória Cafeína Medo Ratos |
description |
In the last decade, several studies have shown that fear memories can be attenuated by interfering with reconsolidation. However, most of the pharmacological agents used in preclinical studies cannot be administered to humans. Caffeine is one of the world’s most popular psychoactive drugs and its effects on cognitive and mood states are well documented. Nevertheless, the influence of caffeine administration on fear memory processing is not as clear. We employed contextual fear conditioning in rats and acute caffeine administration under a standard memory reconsolidation protocol or periodical memory reactivation. Additionally, potential rewarding/aversion and anxiety effects induced by caffeine were evaluated by conditioning place preference or open field, respectively. Caffeine administration was able to attenuate weak fear memories in a standard memory reconsolidation protocol; however, periodical memory reactivation under caffeine effect was necessary to attenuate strong and remote memories. Moreover, caffeine promoted conditioned place preference and anxiolytic-like behavior, suggesting that caffeine weakens the initial learning during reactivation through counterconditioning mechanisms. Thus, our study shows that rewarding and anxiolytic effects of caffeine during fear reactivation can change the emotional valence of fear memory. It brings a new promising pharmacological approach based on drugs widely used such as caffeine to treat fear-related disorders. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2021-08-11T04:46:57Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
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http://hdl.handle.net/10183/225515 |
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2045-2322 |
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001067586 |
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http://hdl.handle.net/10183/225515 |
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eng |
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Scientific reports. London. Vol. 8, (Sept. 2018), 7260, 1-11p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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