Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/203593 |
Resumo: | Elevated ferritin levels may lead to oxidative stress, and are associated with coronary artery disease (CAD). Sleep disordered breathing (SDB) is frequently present in atherosclerosis patients, and causes endothelial dysfunction leading to atherosclerotic plaque progression. Hypoxic conditions, such as SDB, may upregulate ferritin. The aim of this study was to evaluate ferritin levels in CAD patients and to correlate ferritin levels with parameters related to CAD progression, including SDB. We studied 27 patients with CAD (defined as >30% coronary narrowing) and 29 controls. We found that ferritin was increased in CAD patients, and was positively correlated with the apnea–hypopnea index (AHI), age, Creactive protein (CRP), transferrin, hemoglobin, and testosterone levels, and was negatively correlated with O2 saturation. Nitrites and nitrates, an indirect measure of nitric oxide ( NO) concentration, were lower in CAD patients, and were negatively correlated with ferritin. The increase in ferritin may be related to oxidative stress, suggesting a possible pro-atherosclerotic role of increased ferritin in CAD patients with SDB. |
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Hackenhaar, Fernanda SchäferMartinez, DenisKlein, CristiniMedeiros, Tássia MachadoAlabarse, Paulo Vinicius GilWainstein, Marco VugmanGonçalves, Sandro CadavalBenfato, Mara da Silveira2019-12-20T04:03:21Z20151214-0287http://hdl.handle.net/10183/203593000997289Elevated ferritin levels may lead to oxidative stress, and are associated with coronary artery disease (CAD). Sleep disordered breathing (SDB) is frequently present in atherosclerosis patients, and causes endothelial dysfunction leading to atherosclerotic plaque progression. Hypoxic conditions, such as SDB, may upregulate ferritin. The aim of this study was to evaluate ferritin levels in CAD patients and to correlate ferritin levels with parameters related to CAD progression, including SDB. We studied 27 patients with CAD (defined as >30% coronary narrowing) and 29 controls. We found that ferritin was increased in CAD patients, and was positively correlated with the apnea–hypopnea index (AHI), age, Creactive protein (CRP), transferrin, hemoglobin, and testosterone levels, and was negatively correlated with O2 saturation. Nitrites and nitrates, an indirect measure of nitric oxide ( NO) concentration, were lower in CAD patients, and were negatively correlated with ferritin. The increase in ferritin may be related to oxidative stress, suggesting a possible pro-atherosclerotic role of increased ferritin in CAD patients with SDB.application/pdfengJournal of applied biomedicine. České Budějovice, Czech Republic. Vol. 13, n. 4 (Sep. 2015), p. 289–298Apneia obstrutiva do sonoAteroscleroseFerritinasÓxido nítricoEstresse oxidativoSerum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathingEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000997289.pdf.txt000997289.pdf.txtExtracted Texttext/plain36724http://www.lume.ufrgs.br/bitstream/10183/203593/2/000997289.pdf.txtd8d92daa7dae033e41bd71cd65477b6bMD52ORIGINAL000997289.pdfTexto completo (inglês)application/pdf975827http://www.lume.ufrgs.br/bitstream/10183/203593/1/000997289.pdf246e3cd1e49a5486cc6a6e3e4d9502fbMD5110183/2035932023-05-10 03:27:50.660308oai:www.lume.ufrgs.br:10183/203593Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-10T06:27:50Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
title |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
spellingShingle |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing Hackenhaar, Fernanda Schäfer Apneia obstrutiva do sono Aterosclerose Ferritinas Óxido nítrico Estresse oxidativo |
title_short |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
title_full |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
title_fullStr |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
title_full_unstemmed |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
title_sort |
Serum ferritin levels may have a pro-atherosclerotic role in coronary artery disease patients with sleep disordered breathing |
author |
Hackenhaar, Fernanda Schäfer |
author_facet |
Hackenhaar, Fernanda Schäfer Martinez, Denis Klein, Cristini Medeiros, Tássia Machado Alabarse, Paulo Vinicius Gil Wainstein, Marco Vugman Gonçalves, Sandro Cadaval Benfato, Mara da Silveira |
author_role |
author |
author2 |
Martinez, Denis Klein, Cristini Medeiros, Tássia Machado Alabarse, Paulo Vinicius Gil Wainstein, Marco Vugman Gonçalves, Sandro Cadaval Benfato, Mara da Silveira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Hackenhaar, Fernanda Schäfer Martinez, Denis Klein, Cristini Medeiros, Tássia Machado Alabarse, Paulo Vinicius Gil Wainstein, Marco Vugman Gonçalves, Sandro Cadaval Benfato, Mara da Silveira |
dc.subject.por.fl_str_mv |
Apneia obstrutiva do sono Aterosclerose Ferritinas Óxido nítrico Estresse oxidativo |
topic |
Apneia obstrutiva do sono Aterosclerose Ferritinas Óxido nítrico Estresse oxidativo |
description |
Elevated ferritin levels may lead to oxidative stress, and are associated with coronary artery disease (CAD). Sleep disordered breathing (SDB) is frequently present in atherosclerosis patients, and causes endothelial dysfunction leading to atherosclerotic plaque progression. Hypoxic conditions, such as SDB, may upregulate ferritin. The aim of this study was to evaluate ferritin levels in CAD patients and to correlate ferritin levels with parameters related to CAD progression, including SDB. We studied 27 patients with CAD (defined as >30% coronary narrowing) and 29 controls. We found that ferritin was increased in CAD patients, and was positively correlated with the apnea–hypopnea index (AHI), age, Creactive protein (CRP), transferrin, hemoglobin, and testosterone levels, and was negatively correlated with O2 saturation. Nitrites and nitrates, an indirect measure of nitric oxide ( NO) concentration, were lower in CAD patients, and were negatively correlated with ferritin. The increase in ferritin may be related to oxidative stress, suggesting a possible pro-atherosclerotic role of increased ferritin in CAD patients with SDB. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2019-12-20T04:03:21Z |
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Estrangeiro info:eu-repo/semantics/article |
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1214-0287 |
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000997289 |
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eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Journal of applied biomedicine. České Budějovice, Czech Republic. Vol. 13, n. 4 (Sep. 2015), p. 289–298 |
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