Quantification of mixed chimerism allows early therapeutic interventions
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/129045 |
Resumo: | Hematopoietic stem cell transplantation is the curative option for patients with myelodys-plastic syndrome; however, it requires a long post-transplantation follow-up. A 53-year-oldwoman with a diagnosis of myelodysplastic syndrome underwent related donor allogeneichematopoietic stem cell transplantation in July 2006. Three months after transplanta-tion, a comparative short tandem repeat analysis between donor and recipient revealedfull chimerism, indicating complete, healthy bone marrow reconstitution. Three yearsand ten months after hematopoietic stem cell transplantation, the patient developedleukopenia and thrombocytopenia. Another short tandem repeat analysis was carried outwhich showed mixed chimerism (52.62%), indicating relapsed disease. A donor lymphocyteinfusion was administered. The purpose of donor lymphocyte infusion is to induce a graft-versus-leukemia effect; in fact, this donor’s lymphocyte infusion induced full chimerism.Successive short tandem repeat analyses were performed as part of post-transplantationfollow-up, and in July 2010, one such analysis again showed mixed chimerism (64.25%).Based on this finding, a second donor lymphocyte infusion was administered, but failedto eradicate the disease. In September 2011, the patient presented with relapsed dis-ease, and a second related donor allogeneic hematopoietic stem cell transplantationwas performed. Subsequent short tandem repeat analyses revealed full chimerism, indi-cating complete bone marrow reconstitution. We conclude that quantitative detectionof mixed chimerism is an important diagnostic tool that can guide early therapeuticintervention. |
id |
UFRGS-2_0aad874f9dd19dce7d20b8c931baea81 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/129045 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Merzoni, JóiceEwald, Gisele MenezesPaz, Alessandra AparecidaDaudt, Liane EstevesJobim, Luiz Fernando Job2015-11-07T02:37:10Z20141516-8484http://hdl.handle.net/10183/129045000972938Hematopoietic stem cell transplantation is the curative option for patients with myelodys-plastic syndrome; however, it requires a long post-transplantation follow-up. A 53-year-oldwoman with a diagnosis of myelodysplastic syndrome underwent related donor allogeneichematopoietic stem cell transplantation in July 2006. Three months after transplanta-tion, a comparative short tandem repeat analysis between donor and recipient revealedfull chimerism, indicating complete, healthy bone marrow reconstitution. Three yearsand ten months after hematopoietic stem cell transplantation, the patient developedleukopenia and thrombocytopenia. Another short tandem repeat analysis was carried outwhich showed mixed chimerism (52.62%), indicating relapsed disease. A donor lymphocyteinfusion was administered. The purpose of donor lymphocyte infusion is to induce a graft-versus-leukemia effect; in fact, this donor’s lymphocyte infusion induced full chimerism.Successive short tandem repeat analyses were performed as part of post-transplantationfollow-up, and in July 2010, one such analysis again showed mixed chimerism (64.25%).Based on this finding, a second donor lymphocyte infusion was administered, but failedto eradicate the disease. In September 2011, the patient presented with relapsed dis-ease, and a second related donor allogeneic hematopoietic stem cell transplantationwas performed. Subsequent short tandem repeat analyses revealed full chimerism, indi-cating complete bone marrow reconstitution. We conclude that quantitative detectionof mixed chimerism is an important diagnostic tool that can guide early therapeuticintervention.application/pdfporRevista brasileira de hematologia e hemoterapia. São Paulo. Vol. 36, n. 5 (set./out. 2014), p. 369-372QuimerismoTransplante de medula ósseaDoenças mieloproliferativas-mielodisplásicasSequências repetidas em TandemChimerismBone marrow transplantationMyelodysplastic myeloproliferativediseasesTandem repeat sequencesaQuantification of mixed chimerism allows early therapeutic interventionsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000972938.pdf000972938.pdfTexto completo (inglês)application/pdf354057http://www.lume.ufrgs.br/bitstream/10183/129045/1/000972938.pdfa1e360d430e78d82fdff3e35d887301eMD51TEXT000972938.pdf.txt000972938.pdf.txtExtracted Texttext/plain15200http://www.lume.ufrgs.br/bitstream/10183/129045/2/000972938.pdf.txtc2c24782f00cafc26b8dec1e419a643eMD52THUMBNAIL000972938.pdf.jpg000972938.pdf.jpgGenerated Thumbnailimage/jpeg1908http://www.lume.ufrgs.br/bitstream/10183/129045/3/000972938.pdf.jpgef6b05755b0e129ff72a800e342595f1MD5310183/1290452018-10-24 09:09:18.73oai:www.lume.ufrgs.br:10183/129045Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-24T12:09:18Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Quantification of mixed chimerism allows early therapeutic interventions |
title |
Quantification of mixed chimerism allows early therapeutic interventions |
spellingShingle |
Quantification of mixed chimerism allows early therapeutic interventions Merzoni, Jóice Quimerismo Transplante de medula óssea Doenças mieloproliferativas-mielodisplásicas Sequências repetidas em Tandem Chimerism Bone marrow transplantation Myelodysplastic myeloproliferativediseases Tandem repeat sequencesa |
title_short |
Quantification of mixed chimerism allows early therapeutic interventions |
title_full |
Quantification of mixed chimerism allows early therapeutic interventions |
title_fullStr |
Quantification of mixed chimerism allows early therapeutic interventions |
title_full_unstemmed |
Quantification of mixed chimerism allows early therapeutic interventions |
title_sort |
Quantification of mixed chimerism allows early therapeutic interventions |
author |
Merzoni, Jóice |
author_facet |
Merzoni, Jóice Ewald, Gisele Menezes Paz, Alessandra Aparecida Daudt, Liane Esteves Jobim, Luiz Fernando Job |
author_role |
author |
author2 |
Ewald, Gisele Menezes Paz, Alessandra Aparecida Daudt, Liane Esteves Jobim, Luiz Fernando Job |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Merzoni, Jóice Ewald, Gisele Menezes Paz, Alessandra Aparecida Daudt, Liane Esteves Jobim, Luiz Fernando Job |
dc.subject.por.fl_str_mv |
Quimerismo Transplante de medula óssea Doenças mieloproliferativas-mielodisplásicas Sequências repetidas em Tandem |
topic |
Quimerismo Transplante de medula óssea Doenças mieloproliferativas-mielodisplásicas Sequências repetidas em Tandem Chimerism Bone marrow transplantation Myelodysplastic myeloproliferativediseases Tandem repeat sequencesa |
dc.subject.eng.fl_str_mv |
Chimerism Bone marrow transplantation Myelodysplastic myeloproliferativediseases Tandem repeat sequencesa |
description |
Hematopoietic stem cell transplantation is the curative option for patients with myelodys-plastic syndrome; however, it requires a long post-transplantation follow-up. A 53-year-oldwoman with a diagnosis of myelodysplastic syndrome underwent related donor allogeneichematopoietic stem cell transplantation in July 2006. Three months after transplanta-tion, a comparative short tandem repeat analysis between donor and recipient revealedfull chimerism, indicating complete, healthy bone marrow reconstitution. Three yearsand ten months after hematopoietic stem cell transplantation, the patient developedleukopenia and thrombocytopenia. Another short tandem repeat analysis was carried outwhich showed mixed chimerism (52.62%), indicating relapsed disease. A donor lymphocyteinfusion was administered. The purpose of donor lymphocyte infusion is to induce a graft-versus-leukemia effect; in fact, this donor’s lymphocyte infusion induced full chimerism.Successive short tandem repeat analyses were performed as part of post-transplantationfollow-up, and in July 2010, one such analysis again showed mixed chimerism (64.25%).Based on this finding, a second donor lymphocyte infusion was administered, but failedto eradicate the disease. In September 2011, the patient presented with relapsed dis-ease, and a second related donor allogeneic hematopoietic stem cell transplantationwas performed. Subsequent short tandem repeat analyses revealed full chimerism, indi-cating complete bone marrow reconstitution. We conclude that quantitative detectionof mixed chimerism is an important diagnostic tool that can guide early therapeuticintervention. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-11-07T02:37:10Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/129045 |
dc.identifier.issn.pt_BR.fl_str_mv |
1516-8484 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000972938 |
identifier_str_mv |
1516-8484 000972938 |
url |
http://hdl.handle.net/10183/129045 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de hematologia e hemoterapia. São Paulo. Vol. 36, n. 5 (set./out. 2014), p. 369-372 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/129045/1/000972938.pdf http://www.lume.ufrgs.br/bitstream/10183/129045/2/000972938.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/129045/3/000972938.pdf.jpg |
bitstream.checksum.fl_str_mv |
a1e360d430e78d82fdff3e35d887301e c2c24782f00cafc26b8dec1e419a643e ef6b05755b0e129ff72a800e342595f1 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1815447600280633344 |