Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains

Detalhes bibliográficos
Autor(a) principal: Mósena, Ana Cristina Sbaraini
Data de Publicação: 2023
Outros Autores: Ma, Hao, Casas, Eduardo, Dassanayake, Rohana P., Canal, Cláudio Wageck, Neill, John D., Falkenberg, Shollie M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/263879
Resumo: Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates. Results Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates.
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spelling Mósena, Ana Cristina SbarainiMa, HaoCasas, EduardoDassanayake, Rohana P.Canal, Cláudio WageckNeill, John D.Falkenberg, Shollie M.2023-08-23T03:29:19Z20231756-0500http://hdl.handle.net/10183/263879001174488Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates. Results Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates.application/pdfengBMC research notes. London. Vol. 16 (2023), 121, 6 p.AntigenicidadeVírus da diarréia viral bovinaNeutralização viralSoros imunesVacinasEstados UnidosPCAAntigenicityPestivirusBVDVVirus neutralizationMultivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strainsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001174488.pdf.txt001174488.pdf.txtExtracted Texttext/plain23819http://www.lume.ufrgs.br/bitstream/10183/263879/2/001174488.pdf.txt8064d7eedea90c83e144af5526ce9b20MD52ORIGINAL001174488.pdfTexto completo (inglês)application/pdf1223037http://www.lume.ufrgs.br/bitstream/10183/263879/1/001174488.pdf542025430ea0aedf1f09f1ef8c96b6dbMD5110183/2638792023-08-24 03:33:34.910611oai:www.lume.ufrgs.br:10183/263879Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-24T06:33:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
title Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
spellingShingle Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
Mósena, Ana Cristina Sbaraini
Antigenicidade
Vírus da diarréia viral bovina
Neutralização viral
Soros imunes
Vacinas
Estados Unidos
PCA
Antigenicity
Pestivirus
BVDV
Virus neutralization
title_short Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
title_full Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
title_fullStr Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
title_full_unstemmed Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
title_sort Multivariate analysis reveals that BVDV field isolates do not show a close VN-based antigenic relationship to US vaccine strains
author Mósena, Ana Cristina Sbaraini
author_facet Mósena, Ana Cristina Sbaraini
Ma, Hao
Casas, Eduardo
Dassanayake, Rohana P.
Canal, Cláudio Wageck
Neill, John D.
Falkenberg, Shollie M.
author_role author
author2 Ma, Hao
Casas, Eduardo
Dassanayake, Rohana P.
Canal, Cláudio Wageck
Neill, John D.
Falkenberg, Shollie M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mósena, Ana Cristina Sbaraini
Ma, Hao
Casas, Eduardo
Dassanayake, Rohana P.
Canal, Cláudio Wageck
Neill, John D.
Falkenberg, Shollie M.
dc.subject.por.fl_str_mv Antigenicidade
Vírus da diarréia viral bovina
Neutralização viral
Soros imunes
Vacinas
Estados Unidos
topic Antigenicidade
Vírus da diarréia viral bovina
Neutralização viral
Soros imunes
Vacinas
Estados Unidos
PCA
Antigenicity
Pestivirus
BVDV
Virus neutralization
dc.subject.eng.fl_str_mv PCA
Antigenicity
Pestivirus
BVDV
Virus neutralization
description Objective Evaluate bovine viral diarrhea virus (BVDV) antigenicity by using virus neutralization titers (VNT) analyzed using the principal component analysis (PCA) from antisera generated against US-based vaccine strains against both US-origin field isolates and non-US-origin field isolates. Results Data from both independent analyses demonstrated that several US-origin and non-US-origin BVDV field isolates appear to be antigenically divergent from the US-based vaccine strains. Results from the combined analysis provided greater insight into the antigenic diversity observed among BVDV isolates. Data from this study further support genetic assignment into BVDV subgenotypes, as well as strains within subgenotypes is not representative of antigenic relatedness. PCA highlights isolates that are antigenically divergent from members of the same species and subgenotype and conversely isolates that belong to different subgenotypes have similar antigenic characteristics when using antisera from US-based vaccine isolates.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-23T03:29:19Z
dc.date.issued.fl_str_mv 2023
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/263879
dc.identifier.issn.pt_BR.fl_str_mv 1756-0500
dc.identifier.nrb.pt_BR.fl_str_mv 001174488
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv BMC research notes. London. Vol. 16 (2023), 121, 6 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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