Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

Detalhes bibliográficos
Autor(a) principal: Prolla, Patrícia Ashton
Data de Publicação: 2009
Outros Autores: Giacomazzi, Juliana, Schmidt, Aishameriane Venes, Roth, Fernanda Lenara, Palmero, Edenir Inêz, Kalakun, Luciane, Aguiar, Ernestina Silva de, Moreira, Susana Mayer, Batassini, Érica, Belo-Reyes, Vanessa, Faccini, Lavinia Schuler, Giugliani, Roberto, Caleffi, Maira, Camey, Suzi Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21557
Resumo: Background: Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed to reduce risk, has become increasingly relevant. A previous study in Southern Brazil has shown that a family history suggestive of these syndromes may be prevalent at the primary care level. Development of a simple and sensitive instrument, easily applicable in primary care units, would be particularly helpful in underserved communities in which identification and referral of high-risk individuals is difficult. Methods: A simple 7-question instrument about family history of breast, ovarian and colorectal cancer, FHS-7, was developed to screen for individuals with an increased risk for hereditary breast cancer syndromes. FHS-7 was applied to 9218 women during routine visits to primary care units in Southern Brazil. Two consecutive samples of 885 women and 910 women who answered positively to at least one question and negatively to all questions were included, respectively. The sensitivity, specificity and positive and negative predictive values were determined. Results: Of the 885 women reporting a positive family history, 211 (23.8%; CI95%: 21.5–26.2) had a pedigree suggestive of a hereditary breast and/or breast and colorectal cancer syndrome. Using as cut point one positive answer, the sensitivity and specificity of the instrument were 87.6% and 56.4%, respectively. Concordance between answers in two different applications was given by a intra-class correlation (ICC) of 0.84 for at least one positive answer. Temporal stability of the instrument was adequate (ICC = 0.65). Conclusion: A simple instrument for the identification of the most common hereditary breast cancer syndrome phenotypes, showing good specificity and temporal stability was developed and could be used as a screening tool in primary care to refer at-risk individuals for genetic evaluations.
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spelling Prolla, Patrícia AshtonGiacomazzi, JulianaSchmidt, Aishameriane VenesRoth, Fernanda LenaraPalmero, Edenir InêzKalakun, LucianeAguiar, Ernestina Silva deMoreira, Susana MayerBatassini, ÉricaBelo-Reyes, VanessaFaccini, Lavinia SchulerGiugliani, RobertoCaleffi, MairaCamey, Suzi Alves2010-05-05T04:15:55Z20091471-2407http://hdl.handle.net/10183/21557000715066Background: Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed to reduce risk, has become increasingly relevant. A previous study in Southern Brazil has shown that a family history suggestive of these syndromes may be prevalent at the primary care level. Development of a simple and sensitive instrument, easily applicable in primary care units, would be particularly helpful in underserved communities in which identification and referral of high-risk individuals is difficult. Methods: A simple 7-question instrument about family history of breast, ovarian and colorectal cancer, FHS-7, was developed to screen for individuals with an increased risk for hereditary breast cancer syndromes. FHS-7 was applied to 9218 women during routine visits to primary care units in Southern Brazil. Two consecutive samples of 885 women and 910 women who answered positively to at least one question and negatively to all questions were included, respectively. The sensitivity, specificity and positive and negative predictive values were determined. Results: Of the 885 women reporting a positive family history, 211 (23.8%; CI95%: 21.5–26.2) had a pedigree suggestive of a hereditary breast and/or breast and colorectal cancer syndrome. Using as cut point one positive answer, the sensitivity and specificity of the instrument were 87.6% and 56.4%, respectively. Concordance between answers in two different applications was given by a intra-class correlation (ICC) of 0.84 for at least one positive answer. Temporal stability of the instrument was adequate (ICC = 0.65). Conclusion: A simple instrument for the identification of the most common hereditary breast cancer syndrome phenotypes, showing good specificity and temporal stability was developed and could be used as a screening tool in primary care to refer at-risk individuals for genetic evaluations.application/pdfengBMC Cancer. London. Vol. 9 (Aug. 2009), 9 p.Estatística aplicadaNeoplasias da mamaDoenças genéticas inatasDevelopment and validation of a simple questionnaire for the identification of hereditary breast cancer in primary careEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000715066.pdf000715066.pdfTexto completo (inglês)application/pdf328661http://www.lume.ufrgs.br/bitstream/10183/21557/1/000715066.pdf32044b1757bd59e21273e430e7e26d14MD51TEXT000715066.pdf.txt000715066.pdf.txtExtracted Texttext/plain40725http://www.lume.ufrgs.br/bitstream/10183/21557/2/000715066.pdf.txtc896fc3a914651d31a0554d769b088d3MD52THUMBNAIL000715066.pdf.jpg000715066.pdf.jpgGenerated Thumbnailimage/jpeg2062http://www.lume.ufrgs.br/bitstream/10183/21557/3/000715066.pdf.jpge61b41ceb7880c8dc80786d5154e1539MD5310183/215572024-01-04 04:29:10.10692oai:www.lume.ufrgs.br:10183/21557Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-01-04T06:29:10Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
title Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
spellingShingle Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
Prolla, Patrícia Ashton
Estatística aplicada
Neoplasias da mama
Doenças genéticas inatas
title_short Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
title_full Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
title_fullStr Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
title_full_unstemmed Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
title_sort Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care
author Prolla, Patrícia Ashton
author_facet Prolla, Patrícia Ashton
Giacomazzi, Juliana
Schmidt, Aishameriane Venes
Roth, Fernanda Lenara
Palmero, Edenir Inêz
Kalakun, Luciane
Aguiar, Ernestina Silva de
Moreira, Susana Mayer
Batassini, Érica
Belo-Reyes, Vanessa
Faccini, Lavinia Schuler
Giugliani, Roberto
Caleffi, Maira
Camey, Suzi Alves
author_role author
author2 Giacomazzi, Juliana
Schmidt, Aishameriane Venes
Roth, Fernanda Lenara
Palmero, Edenir Inêz
Kalakun, Luciane
Aguiar, Ernestina Silva de
Moreira, Susana Mayer
Batassini, Érica
Belo-Reyes, Vanessa
Faccini, Lavinia Schuler
Giugliani, Roberto
Caleffi, Maira
Camey, Suzi Alves
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Prolla, Patrícia Ashton
Giacomazzi, Juliana
Schmidt, Aishameriane Venes
Roth, Fernanda Lenara
Palmero, Edenir Inêz
Kalakun, Luciane
Aguiar, Ernestina Silva de
Moreira, Susana Mayer
Batassini, Érica
Belo-Reyes, Vanessa
Faccini, Lavinia Schuler
Giugliani, Roberto
Caleffi, Maira
Camey, Suzi Alves
dc.subject.por.fl_str_mv Estatística aplicada
Neoplasias da mama
Doenças genéticas inatas
topic Estatística aplicada
Neoplasias da mama
Doenças genéticas inatas
description Background: Breast cancer is a significant public health problem worldwide and the development of tools to identify individuals at-risk for hereditary breast cancer syndromes, where specific interventions can be proposed to reduce risk, has become increasingly relevant. A previous study in Southern Brazil has shown that a family history suggestive of these syndromes may be prevalent at the primary care level. Development of a simple and sensitive instrument, easily applicable in primary care units, would be particularly helpful in underserved communities in which identification and referral of high-risk individuals is difficult. Methods: A simple 7-question instrument about family history of breast, ovarian and colorectal cancer, FHS-7, was developed to screen for individuals with an increased risk for hereditary breast cancer syndromes. FHS-7 was applied to 9218 women during routine visits to primary care units in Southern Brazil. Two consecutive samples of 885 women and 910 women who answered positively to at least one question and negatively to all questions were included, respectively. The sensitivity, specificity and positive and negative predictive values were determined. Results: Of the 885 women reporting a positive family history, 211 (23.8%; CI95%: 21.5–26.2) had a pedigree suggestive of a hereditary breast and/or breast and colorectal cancer syndrome. Using as cut point one positive answer, the sensitivity and specificity of the instrument were 87.6% and 56.4%, respectively. Concordance between answers in two different applications was given by a intra-class correlation (ICC) of 0.84 for at least one positive answer. Temporal stability of the instrument was adequate (ICC = 0.65). Conclusion: A simple instrument for the identification of the most common hereditary breast cancer syndrome phenotypes, showing good specificity and temporal stability was developed and could be used as a screening tool in primary care to refer at-risk individuals for genetic evaluations.
publishDate 2009
dc.date.issued.fl_str_mv 2009
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dc.identifier.issn.pt_BR.fl_str_mv 1471-2407
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dc.relation.ispartof.pt_BR.fl_str_mv BMC Cancer. London. Vol. 9 (Aug. 2009), 9 p.
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