Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21245 |
Resumo: | We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced-fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 ± 11.7 years. Individuals who presented at least one high alteration in total cholesterol, low-density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic. Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43%. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2% of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population. This gene represents a potential locus for a nutrigenetic directed approach. |
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Barcelos, A. L. V.Chies, R.Almeida, Sabrina Esteves de MatosFiegenbaum, MariluPerry, Ingrid Dalira SchweigertChula, Fernanda Goulart LanesRossetti, Maria Lucia RosaSilva, Cláudia Maria Dornelles da2010-04-24T04:15:56Z20090100-879Xhttp://hdl.handle.net/10183/21245000730432We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced-fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 ± 11.7 years. Individuals who presented at least one high alteration in total cholesterol, low-density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic. Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43%. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2% of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population. This gene represents a potential locus for a nutrigenetic directed approach.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 42, n. 6 (jun. 2009), p. 487-493DislipidemiasPolimorfismo genéticoDietaColesterol 7-alfa-hidroxilaseDyslipidemiaPolymorphismsDietCYP7A1Southern BrazilAssociation of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patientsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000730432.pdf.txt000730432.pdf.txtExtracted Texttext/plain30898http://www.lume.ufrgs.br/bitstream/10183/21245/2/000730432.pdf.txt9e39feae1172462f20524ce9275ac29fMD52ORIGINAL000730432.pdf000730432.pdfTexto completo (inglês)application/pdf109868http://www.lume.ufrgs.br/bitstream/10183/21245/1/000730432.pdf54ed66bde50157c895909d665b437af4MD51THUMBNAIL000730432.pdf.jpg000730432.pdf.jpgGenerated Thumbnailimage/jpeg1934http://www.lume.ufrgs.br/bitstream/10183/21245/3/000730432.pdf.jpg48e9a0c78a0024adc5993e5a9de2f0e0MD5310183/212452018-10-05 08:17:43.73oai:www.lume.ufrgs.br:10183/21245Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-05T11:17:43Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
title |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
spellingShingle |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients Barcelos, A. L. V. Dislipidemias Polimorfismo genético Dieta Colesterol 7-alfa-hidroxilase Dyslipidemia Polymorphisms Diet CYP7A1 Southern Brazil |
title_short |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
title_full |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
title_fullStr |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
title_full_unstemmed |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
title_sort |
Association of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patients |
author |
Barcelos, A. L. V. |
author_facet |
Barcelos, A. L. V. Chies, R. Almeida, Sabrina Esteves de Matos Fiegenbaum, Marilu Perry, Ingrid Dalira Schweigert Chula, Fernanda Goulart Lanes Rossetti, Maria Lucia Rosa Silva, Cláudia Maria Dornelles da |
author_role |
author |
author2 |
Chies, R. Almeida, Sabrina Esteves de Matos Fiegenbaum, Marilu Perry, Ingrid Dalira Schweigert Chula, Fernanda Goulart Lanes Rossetti, Maria Lucia Rosa Silva, Cláudia Maria Dornelles da |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Barcelos, A. L. V. Chies, R. Almeida, Sabrina Esteves de Matos Fiegenbaum, Marilu Perry, Ingrid Dalira Schweigert Chula, Fernanda Goulart Lanes Rossetti, Maria Lucia Rosa Silva, Cláudia Maria Dornelles da |
dc.subject.por.fl_str_mv |
Dislipidemias Polimorfismo genético Dieta Colesterol 7-alfa-hidroxilase |
topic |
Dislipidemias Polimorfismo genético Dieta Colesterol 7-alfa-hidroxilase Dyslipidemia Polymorphisms Diet CYP7A1 Southern Brazil |
dc.subject.eng.fl_str_mv |
Dyslipidemia Polymorphisms Diet CYP7A1 Southern Brazil |
description |
We investigated the effect of the -278A>C polymorphism in the CYP7A1 gene on the response of plasma lipids to a reduced-fat diet for 6 to 8 weeks in a group of 82 dyslipidemic males with a mean age of 46.0 ± 11.7 years. Individuals who presented at least one high alteration in total cholesterol, low-density lipoprotein cholesterol or triglyceride values were considered to be dyslipidemic. Exclusion criteria were secondary dyslipidemia due to diabetes mellitus, renal, liver, or thyroid disease. None of the subjects were using lipid-lowering medication. Baseline and follow-up lipid concentrations were measured. The genotypes were determined by the digestion of PCR products with the BsaI restriction endonuclease. There were statistically significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations after dietary intervention. The minor allele C has a frequency of 43%. Carriers of the C allele had significantly lower triglyceride concentrations (P = 0.02) than AA homozygotes. After adjustment of covariates, subjects with the AC and CC genotypes showed a greater reduction in triglyceride concentrations compared to subjects with the AA genotype. Multiple linear regression analyses showed that the AC and CC CYP7A1 genotypes accounted for 5.2 and 6.2% of triglyceride concentration during follow-up and adjusted percent of change of triglyceride concentration, respectively. The present study provides evidence that -278A>C polymorphism in the CYP7A1 gene can modify triglyceride concentrations in response to a reduced fat diet in a dyslipidemic male population. This gene represents a potential locus for a nutrigenetic directed approach. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:56Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21245 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000730432 |
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0100-879X 000730432 |
url |
http://hdl.handle.net/10183/21245 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 42, n. 6 (jun. 2009), p. 487-493 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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