Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01)
Autor(a) principal: | |
---|---|
Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21888 |
Resumo: | Objective: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer’s disease (AD) in a computerized neuropsychological test battery (CNTB). Method:Thirty-three patients with probable AD were treated with galantamine for three months and evaluated in a prospective, open-label, multi-center study. The CNTB and the ADAS-Cog were administered at baseline and after 12 weeks. The CNTB includes reaction time tests to evaluate attention, implicit and episodic memory for faces and words. Statistical comparisons were performed between the results in week 12 versus baseline. Patients who did not reach the therapeutic doses were excluded from the efficacy analysis. Results: Four patients (12.1%) were excluded from the analysis either because of treatment discontinuation (n=3) or because a therapeutic dose was not reached (n=1).The remaining 29 patients were treated with doses of 24 mg/day (n=22) and 16 mg/day (n=7). After 12 weeks, significant reductions in reaction time were seen in the test of episodic memory for faces (p=0.023) and in the test of two-choice reaction time (p=0.039) of the CNTB. Conclusion: Treatment with galantamine produced improvement in computerized tests of attention and episodic memory after 12 weeks, leading to statistically significant reduction in the reaction times. |
id |
UFRGS-2_111987e32c1e0dfa440d3e52dc40e17c |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/21888 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Caramelli, PauloChaves, Marcia Lorena FagundesEngelhardt, EliaseMachado, João Carlos B.Schultz, Rodrigo R.Vale, Francisco A. C.Charchat, Helenice2010-05-12T04:16:35Z20040004-282Xhttp://hdl.handle.net/10183/21888000507516Objective: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer’s disease (AD) in a computerized neuropsychological test battery (CNTB). Method:Thirty-three patients with probable AD were treated with galantamine for three months and evaluated in a prospective, open-label, multi-center study. The CNTB and the ADAS-Cog were administered at baseline and after 12 weeks. The CNTB includes reaction time tests to evaluate attention, implicit and episodic memory for faces and words. Statistical comparisons were performed between the results in week 12 versus baseline. Patients who did not reach the therapeutic doses were excluded from the efficacy analysis. Results: Four patients (12.1%) were excluded from the analysis either because of treatment discontinuation (n=3) or because a therapeutic dose was not reached (n=1).The remaining 29 patients were treated with doses of 24 mg/day (n=22) and 16 mg/day (n=7). After 12 weeks, significant reductions in reaction time were seen in the test of episodic memory for faces (p=0.023) and in the test of two-choice reaction time (p=0.039) of the CNTB. Conclusion: Treatment with galantamine produced improvement in computerized tests of attention and episodic memory after 12 weeks, leading to statistically significant reduction in the reaction times.application/pdfengArquivos de neuro-psiquiatria. Vol. 62, n. 2B (jun. 2004), p. 379-384Doença de AlzheimerNeurofisiologiaAlzheimer’s diseaseClinical trialGalantamineComputerized neuropsychological testsAttentionMemoryEffects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01)info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000507516.pdf000507516.pdfTexto completo (inglês)application/pdf183574http://www.lume.ufrgs.br/bitstream/10183/21888/1/000507516.pdf5b82cb1a05fad5d44ab8847013fbc7bfMD51TEXT000507516.pdf.txt000507516.pdf.txtExtracted Texttext/plain28132http://www.lume.ufrgs.br/bitstream/10183/21888/2/000507516.pdf.txtbf0216db4df0ac6251b62c132c5f0b46MD52THUMBNAIL000507516.pdf.jpg000507516.pdf.jpgGenerated Thumbnailimage/jpeg1716http://www.lume.ufrgs.br/bitstream/10183/21888/3/000507516.pdf.jpg196cbe4e57996b985b2784e81f27b7a3MD5310183/218882023-06-03 03:37:26.36947oai:www.lume.ufrgs.br:10183/21888Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-03T06:37:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
title |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
spellingShingle |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) Caramelli, Paulo Doença de Alzheimer Neurofisiologia Alzheimer’s disease Clinical trial Galantamine Computerized neuropsychological tests Attention Memory |
title_short |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
title_full |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
title_fullStr |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
title_full_unstemmed |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
title_sort |
Effects of galantamine on attention and memory in Alzheimer's disease measured by computerized neuropsychological tests : results of the Brazilian Multi-Center Galantamine Study (GAL-BRA-01) |
author |
Caramelli, Paulo |
author_facet |
Caramelli, Paulo Chaves, Marcia Lorena Fagundes Engelhardt, Eliase Machado, João Carlos B. Schultz, Rodrigo R. Vale, Francisco A. C. Charchat, Helenice |
author_role |
author |
author2 |
Chaves, Marcia Lorena Fagundes Engelhardt, Eliase Machado, João Carlos B. Schultz, Rodrigo R. Vale, Francisco A. C. Charchat, Helenice |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Caramelli, Paulo Chaves, Marcia Lorena Fagundes Engelhardt, Eliase Machado, João Carlos B. Schultz, Rodrigo R. Vale, Francisco A. C. Charchat, Helenice |
dc.subject.por.fl_str_mv |
Doença de Alzheimer Neurofisiologia |
topic |
Doença de Alzheimer Neurofisiologia Alzheimer’s disease Clinical trial Galantamine Computerized neuropsychological tests Attention Memory |
dc.subject.eng.fl_str_mv |
Alzheimer’s disease Clinical trial Galantamine Computerized neuropsychological tests Attention Memory |
description |
Objective: To investigate the effects of galantamine on the performance of patients with mild to moderate Alzheimer’s disease (AD) in a computerized neuropsychological test battery (CNTB). Method:Thirty-three patients with probable AD were treated with galantamine for three months and evaluated in a prospective, open-label, multi-center study. The CNTB and the ADAS-Cog were administered at baseline and after 12 weeks. The CNTB includes reaction time tests to evaluate attention, implicit and episodic memory for faces and words. Statistical comparisons were performed between the results in week 12 versus baseline. Patients who did not reach the therapeutic doses were excluded from the efficacy analysis. Results: Four patients (12.1%) were excluded from the analysis either because of treatment discontinuation (n=3) or because a therapeutic dose was not reached (n=1).The remaining 29 patients were treated with doses of 24 mg/day (n=22) and 16 mg/day (n=7). After 12 weeks, significant reductions in reaction time were seen in the test of episodic memory for faces (p=0.023) and in the test of two-choice reaction time (p=0.039) of the CNTB. Conclusion: Treatment with galantamine produced improvement in computerized tests of attention and episodic memory after 12 weeks, leading to statistically significant reduction in the reaction times. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2010-05-12T04:16:35Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21888 |
dc.identifier.issn.pt_BR.fl_str_mv |
0004-282X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000507516 |
identifier_str_mv |
0004-282X 000507516 |
url |
http://hdl.handle.net/10183/21888 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Arquivos de neuro-psiquiatria. Vol. 62, n. 2B (jun. 2004), p. 379-384 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/21888/1/000507516.pdf http://www.lume.ufrgs.br/bitstream/10183/21888/2/000507516.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/21888/3/000507516.pdf.jpg |
bitstream.checksum.fl_str_mv |
5b82cb1a05fad5d44ab8847013fbc7bf bf0216db4df0ac6251b62c132c5f0b46 196cbe4e57996b985b2784e81f27b7a3 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1798487090468487168 |