Sexual function and chemotherapy in postmenopausal women with breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/109970 |
Resumo: | Background: This cross-sectional, nested cohort study assessed Female Sexual Function Index (FSFI) scores in postmenopausal women with breast cancer receiving primary chemotherapy. Methods: The FSFI questionnaire was administered to 24 postmenopausal women one month after diagnosis of breast cancer (post-diagnosis group) and one month after completion of the first cycle of primary anthracyclin-based chemotherapy (post-chemotherapy group). Scores were compared to those of 24 healthy postmenopausal women seeking routine gynecological care (control group). All patients were sexually active at the time of enrollment. Mean age was 57.29 ± 11.82 years in the breast cancer group and 52.58 ± 7.19 years in the control group. Results: Scores in all domains of the FSFI instrument were significantly lower in the post-diagnosis group than in controls (−41.3%, p < 0.001). A further major reduction in FSFI scores was evident on completion of one cycle of primary chemotherapy (down 46.7% from post-diagnosis scores, p < 0.003), again in all domains. Six patients (25%) ceased all sexual relations, in a significant change from baseline (p < 0.001). After one chemotherapy cycle, a further five patients ceased sexual activity, for a total of 11 (45.8%) participants – a borderline significant difference (p = 0.063). Conclusion: The present study shows that female sexual function as assessed by the FSFI declines significantly at two distinct points in time: upon diagnosis of breast cancer and after administration of systemic chemotherapy. |
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Cavalheiro, José Antônio CrespoBittelbrunn, Ana Cristina da CostaMenke, Carlos HenriqueBiazús, Jorge VillanovaXavier, Nilton LeiteCericatto, RodrigoSchuh, FernandoPinheiro, Caroline VieiraPassos, Eduardo Pandolfi2015-02-11T02:18:10Z20121472-6874http://hdl.handle.net/10183/109970000865639Background: This cross-sectional, nested cohort study assessed Female Sexual Function Index (FSFI) scores in postmenopausal women with breast cancer receiving primary chemotherapy. Methods: The FSFI questionnaire was administered to 24 postmenopausal women one month after diagnosis of breast cancer (post-diagnosis group) and one month after completion of the first cycle of primary anthracyclin-based chemotherapy (post-chemotherapy group). Scores were compared to those of 24 healthy postmenopausal women seeking routine gynecological care (control group). All patients were sexually active at the time of enrollment. Mean age was 57.29 ± 11.82 years in the breast cancer group and 52.58 ± 7.19 years in the control group. Results: Scores in all domains of the FSFI instrument were significantly lower in the post-diagnosis group than in controls (−41.3%, p < 0.001). A further major reduction in FSFI scores was evident on completion of one cycle of primary chemotherapy (down 46.7% from post-diagnosis scores, p < 0.003), again in all domains. Six patients (25%) ceased all sexual relations, in a significant change from baseline (p < 0.001). After one chemotherapy cycle, a further five patients ceased sexual activity, for a total of 11 (45.8%) participants – a borderline significant difference (p = 0.063). Conclusion: The present study shows that female sexual function as assessed by the FSFI declines significantly at two distinct points in time: upon diagnosis of breast cancer and after administration of systemic chemotherapy.application/pdfengBMC women's health. London. Vol. 12 (Sep. 2012), 8 p.Comportamento sexualTratamento farmacológicoAntineoplásicosFarmacologiaNeoplasias da mamaSexualidadeSexual functionBreast cancerChemotherapySexualityFSFISexual function and chemotherapy in postmenopausal women with breast cancerEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000865639.pdf000865639.pdfTexto completo (inglês)application/pdf169924http://www.lume.ufrgs.br/bitstream/10183/109970/1/000865639.pdf441a1d59f633331a4343ab797a715796MD51TEXT000865639.pdf.txt000865639.pdf.txtExtracted Texttext/plain34631http://www.lume.ufrgs.br/bitstream/10183/109970/2/000865639.pdf.txt290e5af8ae10b0f4211495deb7f81587MD52THUMBNAIL000865639.pdf.jpg000865639.pdf.jpgGenerated Thumbnailimage/jpeg1966http://www.lume.ufrgs.br/bitstream/10183/109970/3/000865639.pdf.jpg76067de028ad9363d584894c27bab409MD5310183/1099702023-08-17 03:36:14.387495oai:www.lume.ufrgs.br:10183/109970Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-17T06:36:14Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
title |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
spellingShingle |
Sexual function and chemotherapy in postmenopausal women with breast cancer Cavalheiro, José Antônio Crespo Comportamento sexual Tratamento farmacológico Antineoplásicos Farmacologia Neoplasias da mama Sexualidade Sexual function Breast cancer Chemotherapy Sexuality FSFI |
title_short |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
title_full |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
title_fullStr |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
title_full_unstemmed |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
title_sort |
Sexual function and chemotherapy in postmenopausal women with breast cancer |
author |
Cavalheiro, José Antônio Crespo |
author_facet |
Cavalheiro, José Antônio Crespo Bittelbrunn, Ana Cristina da Costa Menke, Carlos Henrique Biazús, Jorge Villanova Xavier, Nilton Leite Cericatto, Rodrigo Schuh, Fernando Pinheiro, Caroline Vieira Passos, Eduardo Pandolfi |
author_role |
author |
author2 |
Bittelbrunn, Ana Cristina da Costa Menke, Carlos Henrique Biazús, Jorge Villanova Xavier, Nilton Leite Cericatto, Rodrigo Schuh, Fernando Pinheiro, Caroline Vieira Passos, Eduardo Pandolfi |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cavalheiro, José Antônio Crespo Bittelbrunn, Ana Cristina da Costa Menke, Carlos Henrique Biazús, Jorge Villanova Xavier, Nilton Leite Cericatto, Rodrigo Schuh, Fernando Pinheiro, Caroline Vieira Passos, Eduardo Pandolfi |
dc.subject.por.fl_str_mv |
Comportamento sexual Tratamento farmacológico Antineoplásicos Farmacologia Neoplasias da mama Sexualidade |
topic |
Comportamento sexual Tratamento farmacológico Antineoplásicos Farmacologia Neoplasias da mama Sexualidade Sexual function Breast cancer Chemotherapy Sexuality FSFI |
dc.subject.eng.fl_str_mv |
Sexual function Breast cancer Chemotherapy Sexuality FSFI |
description |
Background: This cross-sectional, nested cohort study assessed Female Sexual Function Index (FSFI) scores in postmenopausal women with breast cancer receiving primary chemotherapy. Methods: The FSFI questionnaire was administered to 24 postmenopausal women one month after diagnosis of breast cancer (post-diagnosis group) and one month after completion of the first cycle of primary anthracyclin-based chemotherapy (post-chemotherapy group). Scores were compared to those of 24 healthy postmenopausal women seeking routine gynecological care (control group). All patients were sexually active at the time of enrollment. Mean age was 57.29 ± 11.82 years in the breast cancer group and 52.58 ± 7.19 years in the control group. Results: Scores in all domains of the FSFI instrument were significantly lower in the post-diagnosis group than in controls (−41.3%, p < 0.001). A further major reduction in FSFI scores was evident on completion of one cycle of primary chemotherapy (down 46.7% from post-diagnosis scores, p < 0.003), again in all domains. Six patients (25%) ceased all sexual relations, in a significant change from baseline (p < 0.001). After one chemotherapy cycle, a further five patients ceased sexual activity, for a total of 11 (45.8%) participants – a borderline significant difference (p = 0.063). Conclusion: The present study shows that female sexual function as assessed by the FSFI declines significantly at two distinct points in time: upon diagnosis of breast cancer and after administration of systemic chemotherapy. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2015-02-11T02:18:10Z |
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http://hdl.handle.net/10183/109970 |
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1472-6874 |
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000865639 |
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http://hdl.handle.net/10183/109970 |
dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
BMC women's health. London. Vol. 12 (Sep. 2012), 8 p. |
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openAccess |
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