The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/172663 |
Resumo: | Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition. |
id |
UFRGS-2_14a47118ac4e592997e1e62e77a50567 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/172663 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Dietrich, FabríciaMartins, Jerônimo PietrobonKaiser, SamuelSilva, Rodrigo Bradiccini Madeira daRockenbach, LilianaEdelweiss, Maria Isabel AlbanoOrtega, George GonzálezMorrone, Fernanda BuenoCampos, Maria MarthaBattastini, Ana Maria Oliveira2018-02-20T02:25:51Z20151932-6203http://hdl.handle.net/10183/172663001059794Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition.application/pdfengPLoS ONE. San Francisco. Vol. 10, no. 7 (Jul. 2015), e0131882, 15 p.Unha de gatoCistiteTranstornos hemorrágicosCiclofosfamidaThe quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in miceEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001059794.pdf001059794.pdfTexto completo (inglês)application/pdf2411643http://www.lume.ufrgs.br/bitstream/10183/172663/1/001059794.pdfacdd360ebb62c0e61c4b2b3c86f52dfbMD51TEXT001059794.pdf.txt001059794.pdf.txtExtracted Texttext/plain46330http://www.lume.ufrgs.br/bitstream/10183/172663/2/001059794.pdf.txt40f1f92a61faa4b7b63d0beae3ed4ee9MD52THUMBNAIL001059794.pdf.jpg001059794.pdf.jpgGenerated Thumbnailimage/jpeg1934http://www.lume.ufrgs.br/bitstream/10183/172663/3/001059794.pdf.jpg932267144668972946970813a2b0d4beMD5310183/1726632023-09-23 03:36:08.894325oai:www.lume.ufrgs.br:10183/172663Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:36:08Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
title |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
spellingShingle |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice Dietrich, Fabrícia Unha de gato Cistite Transtornos hemorrágicos Ciclofosfamida |
title_short |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
title_full |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
title_fullStr |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
title_full_unstemmed |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
title_sort |
The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice |
author |
Dietrich, Fabrícia |
author_facet |
Dietrich, Fabrícia Martins, Jerônimo Pietrobon Kaiser, Samuel Silva, Rodrigo Bradiccini Madeira da Rockenbach, Liliana Edelweiss, Maria Isabel Albano Ortega, George González Morrone, Fernanda Bueno Campos, Maria Martha Battastini, Ana Maria Oliveira |
author_role |
author |
author2 |
Martins, Jerônimo Pietrobon Kaiser, Samuel Silva, Rodrigo Bradiccini Madeira da Rockenbach, Liliana Edelweiss, Maria Isabel Albano Ortega, George González Morrone, Fernanda Bueno Campos, Maria Martha Battastini, Ana Maria Oliveira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dietrich, Fabrícia Martins, Jerônimo Pietrobon Kaiser, Samuel Silva, Rodrigo Bradiccini Madeira da Rockenbach, Liliana Edelweiss, Maria Isabel Albano Ortega, George González Morrone, Fernanda Bueno Campos, Maria Martha Battastini, Ana Maria Oliveira |
dc.subject.por.fl_str_mv |
Unha de gato Cistite Transtornos hemorrágicos Ciclofosfamida |
topic |
Unha de gato Cistite Transtornos hemorrágicos Ciclofosfamida |
description |
Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions. It has been demonstrated that the purinergic system is involved in several pathophysiological events. Among purinergic receptors, P2X7 deserves attention because it is involved in HE induced by CYP and, therefore, can be considered a therapeutic target. The objective of this study was to investigate the potential therapeutic effect of the quinovic acid glycosides purified fraction (QAPF) from U. tomentosa in the mouse model of CYP-induced HE. Pretreatment with QAPF not only had a protective effect on HE-induced urothelial damage (edema, hemorrhage and bladder wet weight) but was also able to control visceral pain, decrease IL-1β levels and down-regulates P2X7 receptors, most likely by inhibit the neutrophils migration to the bladder. This research clearly demonstrates the promising anti-inflammatory properties of QAPF, supporting its use as complementary therapy. QAPF represents a promising therapeutic option for this pathological condition. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2018-02-20T02:25:51Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/172663 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001059794 |
identifier_str_mv |
1932-6203 001059794 |
url |
http://hdl.handle.net/10183/172663 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 10, no. 7 (Jul. 2015), e0131882, 15 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/172663/1/001059794.pdf http://www.lume.ufrgs.br/bitstream/10183/172663/2/001059794.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/172663/3/001059794.pdf.jpg |
bitstream.checksum.fl_str_mv |
acdd360ebb62c0e61c4b2b3c86f52dfb 40f1f92a61faa4b7b63d0beae3ed4ee9 932267144668972946970813a2b0d4be |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224936737472512 |