The TP53 fertility network
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/87952 |
Resumo: | The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed “guardian of the genome”, TP53 occupies a central node in stress response networks. The p53 protein has a key role as transcription factor in limiting oncogenesis through several growth suppressive functions, such as initiating apoptosis, senescence, or cell cycle arrest. The p53 protein is directly inactivated in about 50% of all tumors as a result of somatic gene mutations or deletions, and over 80% of tumors demonstrate dysfunctional p53 signaling. Beyond the undeniable importance of p53 as a tumor suppressor, an increasing number of new functions for p53 have been reported, including its ability to regulate energy metabolism, to control autophagy, and to participate in various aspects of differentiation and development. Recently, studies on genetic variations in TP53 among different populations have led to the notion that the p53 protein might play an important role in regulating fertility. This review summarizes current knowledge on the basic functions of different genes of the TP53 family and TP53 pathway with respect to fertility. We also provide original analyses based on genomic and genotype databases, providing further insights into the possible roles of the TP53 pathway in human reproduction. |
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Paskulin, Diego D'ÁvilaPaixão Côrtes, Vanessa RodriguesHainaut, PierreBortolini, Maria CátiraProlla, Patrícia Ashton2014-02-28T01:50:33Z20121415-4757http://hdl.handle.net/10183/87952000871437The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed “guardian of the genome”, TP53 occupies a central node in stress response networks. The p53 protein has a key role as transcription factor in limiting oncogenesis through several growth suppressive functions, such as initiating apoptosis, senescence, or cell cycle arrest. The p53 protein is directly inactivated in about 50% of all tumors as a result of somatic gene mutations or deletions, and over 80% of tumors demonstrate dysfunctional p53 signaling. Beyond the undeniable importance of p53 as a tumor suppressor, an increasing number of new functions for p53 have been reported, including its ability to regulate energy metabolism, to control autophagy, and to participate in various aspects of differentiation and development. Recently, studies on genetic variations in TP53 among different populations have led to the notion that the p53 protein might play an important role in regulating fertility. This review summarizes current knowledge on the basic functions of different genes of the TP53 family and TP53 pathway with respect to fertility. We also provide original analyses based on genomic and genotype databases, providing further insights into the possible roles of the TP53 pathway in human reproduction.application/pdfengGenetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (Dec. 2012), p. 939-946Genes p53Fertilidade humanaTP53fertilityp53 networkThe TP53 fertility networkinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000871437.pdf000871437.pdfTexto completo (inglês)application/pdf1216146http://www.lume.ufrgs.br/bitstream/10183/87952/1/000871437.pdff1da35b349ec5d943b257787ef915b61MD51TEXT000871437.pdf.txt000871437.pdf.txtExtracted Texttext/plain37734http://www.lume.ufrgs.br/bitstream/10183/87952/2/000871437.pdf.txt90f6fd648b984a54cb391d3b6b4c0e55MD52THUMBNAIL000871437.pdf.jpg000871437.pdf.jpgGenerated Thumbnailimage/jpeg1799http://www.lume.ufrgs.br/bitstream/10183/87952/3/000871437.pdf.jpg58d3e098fb6544b82956f5af507682efMD5310183/879522021-07-09 04:37:18.970205oai:www.lume.ufrgs.br:10183/87952Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:37:18Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The TP53 fertility network |
title |
The TP53 fertility network |
spellingShingle |
The TP53 fertility network Paskulin, Diego D'Ávila Genes p53 Fertilidade humana TP53 fertility p53 network |
title_short |
The TP53 fertility network |
title_full |
The TP53 fertility network |
title_fullStr |
The TP53 fertility network |
title_full_unstemmed |
The TP53 fertility network |
title_sort |
The TP53 fertility network |
author |
Paskulin, Diego D'Ávila |
author_facet |
Paskulin, Diego D'Ávila Paixão Côrtes, Vanessa Rodrigues Hainaut, Pierre Bortolini, Maria Cátira Prolla, Patrícia Ashton |
author_role |
author |
author2 |
Paixão Côrtes, Vanessa Rodrigues Hainaut, Pierre Bortolini, Maria Cátira Prolla, Patrícia Ashton |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Paskulin, Diego D'Ávila Paixão Côrtes, Vanessa Rodrigues Hainaut, Pierre Bortolini, Maria Cátira Prolla, Patrícia Ashton |
dc.subject.por.fl_str_mv |
Genes p53 Fertilidade humana |
topic |
Genes p53 Fertilidade humana TP53 fertility p53 network |
dc.subject.eng.fl_str_mv |
TP53 fertility p53 network |
description |
The TP53 gene, first described in 1979, was identified as a tumor suppressor gene in 1989, when it became clear that its product, the p53 nuclear phosphoprotein, was frequently inactivated in many different forms of cancers. Nicknamed “guardian of the genome”, TP53 occupies a central node in stress response networks. The p53 protein has a key role as transcription factor in limiting oncogenesis through several growth suppressive functions, such as initiating apoptosis, senescence, or cell cycle arrest. The p53 protein is directly inactivated in about 50% of all tumors as a result of somatic gene mutations or deletions, and over 80% of tumors demonstrate dysfunctional p53 signaling. Beyond the undeniable importance of p53 as a tumor suppressor, an increasing number of new functions for p53 have been reported, including its ability to regulate energy metabolism, to control autophagy, and to participate in various aspects of differentiation and development. Recently, studies on genetic variations in TP53 among different populations have led to the notion that the p53 protein might play an important role in regulating fertility. This review summarizes current knowledge on the basic functions of different genes of the TP53 family and TP53 pathway with respect to fertility. We also provide original analyses based on genomic and genotype databases, providing further insights into the possible roles of the TP53 pathway in human reproduction. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-02-28T01:50:33Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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publishedVersion |
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http://hdl.handle.net/10183/87952 |
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1415-4757 |
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000871437 |
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http://hdl.handle.net/10183/87952 |
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eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto, SP. Vol. 35, n. 4 supl (Dec. 2012), p. 939-946 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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