Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/255538 |
Resumo: | Rare diseases (RDs) cause considerable death and disability in Latin America. Still, there is no consensus on their definition across the region. Patients with RDs face a diagnostic odyssey to find a correct diagnosis, which may last many years and creates a burden for caregivers, healthcare systems, and society. These diagnostic delays have repercussions on the health and economic burden created by RDs and continue to represent an unmet medical need. This review analyzes barriers to the widespread adoption of newborn screening (NBS) programs and early diagnostic methods for RDs in Latin America and provides recommendations to achieve this critical objective. Increasing the adoption of NBS programs and promoting early diagnosis of RDs are the first steps to improving health outcomes for patients living with RDs. A coordinated, multistakeholder effort from leaders of patient organizations, government, industry, medical societies, academia, and healthcare services is required to increase the adoption of NBS programs. Patients’ best interests should remain the guiding principle for decisions regarding NBS implementation and early diagnosis for RDs. |
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Giugliani, RobertoTaucher, Silvia CastilloHafez, SylviaOliveira, João BoscoRestrepo, Mariana RicoRozenfeld, PaulaZarante, IgnacioGonzaga-Jauregui, Claudia2023-03-10T03:26:47Z20221664-8021http://hdl.handle.net/10183/255538001161107Rare diseases (RDs) cause considerable death and disability in Latin America. Still, there is no consensus on their definition across the region. Patients with RDs face a diagnostic odyssey to find a correct diagnosis, which may last many years and creates a burden for caregivers, healthcare systems, and society. These diagnostic delays have repercussions on the health and economic burden created by RDs and continue to represent an unmet medical need. This review analyzes barriers to the widespread adoption of newborn screening (NBS) programs and early diagnostic methods for RDs in Latin America and provides recommendations to achieve this critical objective. Increasing the adoption of NBS programs and promoting early diagnosis of RDs are the first steps to improving health outcomes for patients living with RDs. A coordinated, multistakeholder effort from leaders of patient organizations, government, industry, medical societies, academia, and healthcare services is required to increase the adoption of NBS programs. Patients’ best interests should remain the guiding principle for decisions regarding NBS implementation and early diagnosis for RDs.application/pdfengFrontiers in genetics. Lausanne. Vol. 13 (Dec. 2022), 1053559, 18 p.Triagem neonatalDiagnóstico precoceDoenças rarasGenômicaTécnicas de diagnóstico molecularNewborn screeningEarly diagnosisRare diseasesDiagnostic odysseyLatin AmericaGeneticsgenomicsMolecular diagnosisOpportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin AmericaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001161107.pdf.txt001161107.pdf.txtExtracted Texttext/plain58995http://www.lume.ufrgs.br/bitstream/10183/255538/2/001161107.pdf.txt0789455bd9a6df5fd834cbd517803097MD52ORIGINAL001161107.pdfTexto completo (inglês)application/pdf1326476http://www.lume.ufrgs.br/bitstream/10183/255538/1/001161107.pdf0aa89878cb6e0c81fd0aaeb135063f1dMD5110183/2555382023-03-11 03:30:42.275555oai:www.lume.ufrgs.br:10183/255538Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-11T06:30:42Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
title |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
spellingShingle |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America Giugliani, Roberto Triagem neonatal Diagnóstico precoce Doenças raras Genômica Técnicas de diagnóstico molecular Newborn screening Early diagnosis Rare diseases Diagnostic odyssey Latin America Genetics genomics Molecular diagnosis |
title_short |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
title_full |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
title_fullStr |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
title_full_unstemmed |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
title_sort |
Opportunities and challenges for newborn screening and early diagnosis of rare diseases in Latin America |
author |
Giugliani, Roberto |
author_facet |
Giugliani, Roberto Taucher, Silvia Castillo Hafez, Sylvia Oliveira, João Bosco Restrepo, Mariana Rico Rozenfeld, Paula Zarante, Ignacio Gonzaga-Jauregui, Claudia |
author_role |
author |
author2 |
Taucher, Silvia Castillo Hafez, Sylvia Oliveira, João Bosco Restrepo, Mariana Rico Rozenfeld, Paula Zarante, Ignacio Gonzaga-Jauregui, Claudia |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Giugliani, Roberto Taucher, Silvia Castillo Hafez, Sylvia Oliveira, João Bosco Restrepo, Mariana Rico Rozenfeld, Paula Zarante, Ignacio Gonzaga-Jauregui, Claudia |
dc.subject.por.fl_str_mv |
Triagem neonatal Diagnóstico precoce Doenças raras Genômica Técnicas de diagnóstico molecular |
topic |
Triagem neonatal Diagnóstico precoce Doenças raras Genômica Técnicas de diagnóstico molecular Newborn screening Early diagnosis Rare diseases Diagnostic odyssey Latin America Genetics genomics Molecular diagnosis |
dc.subject.eng.fl_str_mv |
Newborn screening Early diagnosis Rare diseases Diagnostic odyssey Latin America Genetics genomics Molecular diagnosis |
description |
Rare diseases (RDs) cause considerable death and disability in Latin America. Still, there is no consensus on their definition across the region. Patients with RDs face a diagnostic odyssey to find a correct diagnosis, which may last many years and creates a burden for caregivers, healthcare systems, and society. These diagnostic delays have repercussions on the health and economic burden created by RDs and continue to represent an unmet medical need. This review analyzes barriers to the widespread adoption of newborn screening (NBS) programs and early diagnostic methods for RDs in Latin America and provides recommendations to achieve this critical objective. Increasing the adoption of NBS programs and promoting early diagnosis of RDs are the first steps to improving health outcomes for patients living with RDs. A coordinated, multistakeholder effort from leaders of patient organizations, government, industry, medical societies, academia, and healthcare services is required to increase the adoption of NBS programs. Patients’ best interests should remain the guiding principle for decisions regarding NBS implementation and early diagnosis for RDs. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-03-10T03:26:47Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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1664-8021 |
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001161107 |
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http://hdl.handle.net/10183/255538 |
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eng |
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Frontiers in genetics. Lausanne. Vol. 13 (Dec. 2022), 1053559, 18 p. |
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