Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/218304 |
Resumo: | Adult male Wistar rats were given either a single training trial or one training trial per day during 3 days followed by a retention test trial in an inhibitory avoidance (IA) task. In animals given a single training trial, pretraining, but not pretest bilateral infusion of the NMDA glutamate receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (AP5) (5.0 lg) into the CA1 hippocampal area blocked IA retention. In animals given three training trials, infusions of AP5 given prior to each of the three training trials severely impaired, but did not block retention. The results indicate that NMDA receptors in the hippocampus are involved in the formation, but not in expression, of aversive memory. In addition, rats given repeated training were able to show a mild improvement of performance across training trials, possibly through mechanisms that do not depend on NMDA receptor activation in the dorsal hippocampus. |
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Roesler, RafaelVianna, Monica Ryff Moreira RocaSchroder, NadjaFerreira, Maria Beatriz CardosoQuevedo, João Luciano de2021-03-02T04:15:45Z20060364-3190http://hdl.handle.net/10183/218304000644471Adult male Wistar rats were given either a single training trial or one training trial per day during 3 days followed by a retention test trial in an inhibitory avoidance (IA) task. In animals given a single training trial, pretraining, but not pretest bilateral infusion of the NMDA glutamate receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (AP5) (5.0 lg) into the CA1 hippocampal area blocked IA retention. In animals given three training trials, infusions of AP5 given prior to each of the three training trials severely impaired, but did not block retention. The results indicate that NMDA receptors in the hippocampus are involved in the formation, but not in expression, of aversive memory. In addition, rats given repeated training were able to show a mild improvement of performance across training trials, possibly through mechanisms that do not depend on NMDA receptor activation in the dorsal hippocampus.application/pdfengNeurochemical research. New York, NY. Vol. 31, no. 5 (May 2006), p. 679-683Plasticidade neuronalReceptores de N-metil-D-aspartatoMemória2-Amino-5-fosfonovaleratoÁcido 2-Amino-5-fosfonopentanóicoNMDA receptorAminophosphonopentanoic acidHippocampusSynaptic plasticityAversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampusEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000644471.pdf.txt000644471.pdf.txtExtracted Texttext/plain0http://www.lume.ufrgs.br/bitstream/10183/218304/2/000644471.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD52ORIGINAL000644471.pdfTexto completo (inglês)application/pdf1301517http://www.lume.ufrgs.br/bitstream/10183/218304/1/000644471.pdfc2e37ffbc79e95c1402089e2ef76ba04MD5110183/2183042021-04-12 08:34:04.516544oai:www.lume.ufrgs.br:10183/218304Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-04-12T11:34:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
title |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
spellingShingle |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus Roesler, Rafael Plasticidade neuronal Receptores de N-metil-D-aspartato Memória 2-Amino-5-fosfonovalerato Ácido 2-Amino-5-fosfonopentanóico NMDA receptor Aminophosphonopentanoic acid Hippocampus Synaptic plasticity |
title_short |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
title_full |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
title_fullStr |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
title_full_unstemmed |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
title_sort |
Aversive learning under different training conditions : effects of NMDA receptor blockade in area CA1 of the hippocampus |
author |
Roesler, Rafael |
author_facet |
Roesler, Rafael Vianna, Monica Ryff Moreira Roca Schroder, Nadja Ferreira, Maria Beatriz Cardoso Quevedo, João Luciano de |
author_role |
author |
author2 |
Vianna, Monica Ryff Moreira Roca Schroder, Nadja Ferreira, Maria Beatriz Cardoso Quevedo, João Luciano de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Roesler, Rafael Vianna, Monica Ryff Moreira Roca Schroder, Nadja Ferreira, Maria Beatriz Cardoso Quevedo, João Luciano de |
dc.subject.por.fl_str_mv |
Plasticidade neuronal Receptores de N-metil-D-aspartato Memória 2-Amino-5-fosfonovalerato Ácido 2-Amino-5-fosfonopentanóico |
topic |
Plasticidade neuronal Receptores de N-metil-D-aspartato Memória 2-Amino-5-fosfonovalerato Ácido 2-Amino-5-fosfonopentanóico NMDA receptor Aminophosphonopentanoic acid Hippocampus Synaptic plasticity |
dc.subject.eng.fl_str_mv |
NMDA receptor Aminophosphonopentanoic acid Hippocampus Synaptic plasticity |
description |
Adult male Wistar rats were given either a single training trial or one training trial per day during 3 days followed by a retention test trial in an inhibitory avoidance (IA) task. In animals given a single training trial, pretraining, but not pretest bilateral infusion of the NMDA glutamate receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (AP5) (5.0 lg) into the CA1 hippocampal area blocked IA retention. In animals given three training trials, infusions of AP5 given prior to each of the three training trials severely impaired, but did not block retention. The results indicate that NMDA receptors in the hippocampus are involved in the formation, but not in expression, of aversive memory. In addition, rats given repeated training were able to show a mild improvement of performance across training trials, possibly through mechanisms that do not depend on NMDA receptor activation in the dorsal hippocampus. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2021-03-02T04:15:45Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/218304 |
dc.identifier.issn.pt_BR.fl_str_mv |
0364-3190 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000644471 |
identifier_str_mv |
0364-3190 000644471 |
url |
http://hdl.handle.net/10183/218304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Neurochemical research. New York, NY. Vol. 31, no. 5 (May 2006), p. 679-683 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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UFRGS |
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Repositório Institucional da UFRGS |
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Repositório Institucional da UFRGS |
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