Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report

Detalhes bibliográficos
Autor(a) principal: Vettorato, Rodrigo
Data de Publicação: 2018
Outros Autores: Heidrich, Daiane, Gomes, Fernanda Fraga, Ribeiro, Amanda Carvalho, Pagani, Danielle Machado, Timotheo, Carina Alves, Amaro, Tais Guarienti, Vettorato, Gerson, Scroferneker, Maria Lucia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/172646
Resumo: We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months.
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spelling Vettorato, RodrigoHeidrich, DaianeGomes, Fernanda FragaRibeiro, Amanda CarvalhoPagani, Danielle MachadoTimotheo, Carina AlvesAmaro, Tais GuarientiVettorato, GersonScroferneker, Maria Lucia2018-02-20T02:25:42Z20182211-7539http://hdl.handle.net/10183/172646001059495We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months.application/pdfengMedical mycology case reports. [Amsterdam]. Vol. 19 (Mar. 2018), p. 18-20Sporothrix schenckiiAntifúngicosEsporotricoseItraconazolSporotrichosisSporothrix schenckiiSenso strictoItraconazoleTerbinafineAntifungal susceptibilitySporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case reportEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001059495.pdf001059495.pdfTexto completo (inglês)application/pdf217551http://www.lume.ufrgs.br/bitstream/10183/172646/1/001059495.pdf7ace3b3195b3735ef13f9ebae1c1dba0MD51TEXT001059495.pdf.txt001059495.pdf.txtExtracted Texttext/plain17683http://www.lume.ufrgs.br/bitstream/10183/172646/2/001059495.pdf.txte2850a7d9d53543a7cb90932c0ea52fbMD52THUMBNAIL001059495.pdf.jpg001059495.pdf.jpgGenerated Thumbnailimage/jpeg1876http://www.lume.ufrgs.br/bitstream/10183/172646/3/001059495.pdf.jpg5f965d9b5bf0b86c24bc94af23bb81b6MD5310183/1726462018-10-29 07:51:26.977oai:www.lume.ufrgs.br:10183/172646Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T10:51:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
title Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
spellingShingle Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
Vettorato, Rodrigo
Sporothrix schenckii
Antifúngicos
Esporotricose
Itraconazol
Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
title_short Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
title_full Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
title_fullStr Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
title_full_unstemmed Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
title_sort Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report
author Vettorato, Rodrigo
author_facet Vettorato, Rodrigo
Heidrich, Daiane
Gomes, Fernanda Fraga
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina Alves
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lucia
author_role author
author2 Heidrich, Daiane
Gomes, Fernanda Fraga
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina Alves
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lucia
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vettorato, Rodrigo
Heidrich, Daiane
Gomes, Fernanda Fraga
Ribeiro, Amanda Carvalho
Pagani, Danielle Machado
Timotheo, Carina Alves
Amaro, Tais Guarienti
Vettorato, Gerson
Scroferneker, Maria Lucia
dc.subject.por.fl_str_mv Sporothrix schenckii
Antifúngicos
Esporotricose
Itraconazol
topic Sporothrix schenckii
Antifúngicos
Esporotricose
Itraconazol
Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
dc.subject.eng.fl_str_mv Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
description We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-02-20T02:25:42Z
dc.date.issued.fl_str_mv 2018
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/172646
dc.identifier.issn.pt_BR.fl_str_mv 2211-7539
dc.identifier.nrb.pt_BR.fl_str_mv 001059495
identifier_str_mv 2211-7539
001059495
url http://hdl.handle.net/10183/172646
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Medical mycology case reports. [Amsterdam]. Vol. 19 (Mar. 2018), p. 18-20
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