Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267615 |
Resumo: | Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly. |
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Baierle, MaríliaVencato, Patrícia HeuserOldenburg, LuizaBordignon, SuelenZibetti, Murilo RicardoTrentini, Clarissa MarceliGarcia, Solange CristinaDuarte, Marta Maria Medeiros FrescuraVeit, Juliana CristinaSomacal, SabrinaEmanuelli, TatianaGrune, TilmanBreusing, Nicolle2023-11-25T03:26:15Z20142072-6643http://hdl.handle.net/10183/267615000944180Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.application/pdfengNutrients. Basel, Switzerland. Vol. 6, n. 9 (Sep. 2014), p. 3624-3640Ácidos graxosHomocisteínaIdosoComprometimento cognitivo leveAgingFatty acidsCognitive declineHomocysteineFatty acid status and its relationship to cognitive decline and homocysteine levels in the elderlyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000944180.pdf.txt000944180.pdf.txtExtracted Texttext/plain50380http://www.lume.ufrgs.br/bitstream/10183/267615/2/000944180.pdf.txt670f8349156a94ce5d3ee77f7e5af147MD52ORIGINAL000944180.pdfTexto completo (inglês)application/pdf857189http://www.lume.ufrgs.br/bitstream/10183/267615/1/000944180.pdfb1bacef2a397c2d1b3875e28634c998aMD5110183/2676152023-12-06 04:24:38.718523oai:www.lume.ufrgs.br:10183/267615Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-12-06T06:24:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
title |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
spellingShingle |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly Baierle, Marília Ácidos graxos Homocisteína Idoso Comprometimento cognitivo leve Aging Fatty acids Cognitive decline Homocysteine |
title_short |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
title_full |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
title_fullStr |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
title_full_unstemmed |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
title_sort |
Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly |
author |
Baierle, Marília |
author_facet |
Baierle, Marília Vencato, Patrícia Heuser Oldenburg, Luiza Bordignon, Suelen Zibetti, Murilo Ricardo Trentini, Clarissa Marceli Garcia, Solange Cristina Duarte, Marta Maria Medeiros Frescura Veit, Juliana Cristina Somacal, Sabrina Emanuelli, Tatiana Grune, Tilman Breusing, Nicolle |
author_role |
author |
author2 |
Vencato, Patrícia Heuser Oldenburg, Luiza Bordignon, Suelen Zibetti, Murilo Ricardo Trentini, Clarissa Marceli Garcia, Solange Cristina Duarte, Marta Maria Medeiros Frescura Veit, Juliana Cristina Somacal, Sabrina Emanuelli, Tatiana Grune, Tilman Breusing, Nicolle |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Baierle, Marília Vencato, Patrícia Heuser Oldenburg, Luiza Bordignon, Suelen Zibetti, Murilo Ricardo Trentini, Clarissa Marceli Garcia, Solange Cristina Duarte, Marta Maria Medeiros Frescura Veit, Juliana Cristina Somacal, Sabrina Emanuelli, Tatiana Grune, Tilman Breusing, Nicolle |
dc.subject.por.fl_str_mv |
Ácidos graxos Homocisteína Idoso Comprometimento cognitivo leve |
topic |
Ácidos graxos Homocisteína Idoso Comprometimento cognitivo leve Aging Fatty acids Cognitive decline Homocysteine |
dc.subject.eng.fl_str_mv |
Aging Fatty acids Cognitive decline Homocysteine |
description |
Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2023-11-25T03:26:15Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267615 |
dc.identifier.issn.pt_BR.fl_str_mv |
2072-6643 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000944180 |
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2072-6643 000944180 |
url |
http://hdl.handle.net/10183/267615 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Nutrients. Basel, Switzerland. Vol. 6, n. 9 (Sep. 2014), p. 3624-3640 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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