Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly

Detalhes bibliográficos
Autor(a) principal: Baierle, Marília
Data de Publicação: 2014
Outros Autores: Vencato, Patrícia Heuser, Oldenburg, Luiza, Bordignon, Suelen, Zibetti, Murilo Ricardo, Trentini, Clarissa Marceli, Garcia, Solange Cristina, Duarte, Marta Maria Medeiros Frescura, Veit, Juliana Cristina, Somacal, Sabrina, Emanuelli, Tatiana, Grune, Tilman, Breusing, Nicolle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/267615
Resumo: Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.
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spelling Baierle, MaríliaVencato, Patrícia HeuserOldenburg, LuizaBordignon, SuelenZibetti, Murilo RicardoTrentini, Clarissa MarceliGarcia, Solange CristinaDuarte, Marta Maria Medeiros FrescuraVeit, Juliana CristinaSomacal, SabrinaEmanuelli, TatianaGrune, TilmanBreusing, Nicolle2023-11-25T03:26:15Z20142072-6643http://hdl.handle.net/10183/267615000944180Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.application/pdfengNutrients. Basel, Switzerland. Vol. 6, n. 9 (Sep. 2014), p. 3624-3640Ácidos graxosHomocisteínaIdosoComprometimento cognitivo leveAgingFatty acidsCognitive declineHomocysteineFatty acid status and its relationship to cognitive decline and homocysteine levels in the elderlyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000944180.pdf.txt000944180.pdf.txtExtracted Texttext/plain50380http://www.lume.ufrgs.br/bitstream/10183/267615/2/000944180.pdf.txt670f8349156a94ce5d3ee77f7e5af147MD52ORIGINAL000944180.pdfTexto completo (inglês)application/pdf857189http://www.lume.ufrgs.br/bitstream/10183/267615/1/000944180.pdfb1bacef2a397c2d1b3875e28634c998aMD5110183/2676152023-12-06 04:24:38.718523oai:www.lume.ufrgs.br:10183/267615Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-12-06T06:24:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
title Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
spellingShingle Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
Baierle, Marília
Ácidos graxos
Homocisteína
Idoso
Comprometimento cognitivo leve
Aging
Fatty acids
Cognitive decline
Homocysteine
title_short Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
title_full Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
title_fullStr Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
title_full_unstemmed Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
title_sort Fatty acid status and its relationship to cognitive decline and homocysteine levels in the elderly
author Baierle, Marília
author_facet Baierle, Marília
Vencato, Patrícia Heuser
Oldenburg, Luiza
Bordignon, Suelen
Zibetti, Murilo Ricardo
Trentini, Clarissa Marceli
Garcia, Solange Cristina
Duarte, Marta Maria Medeiros Frescura
Veit, Juliana Cristina
Somacal, Sabrina
Emanuelli, Tatiana
Grune, Tilman
Breusing, Nicolle
author_role author
author2 Vencato, Patrícia Heuser
Oldenburg, Luiza
Bordignon, Suelen
Zibetti, Murilo Ricardo
Trentini, Clarissa Marceli
Garcia, Solange Cristina
Duarte, Marta Maria Medeiros Frescura
Veit, Juliana Cristina
Somacal, Sabrina
Emanuelli, Tatiana
Grune, Tilman
Breusing, Nicolle
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baierle, Marília
Vencato, Patrícia Heuser
Oldenburg, Luiza
Bordignon, Suelen
Zibetti, Murilo Ricardo
Trentini, Clarissa Marceli
Garcia, Solange Cristina
Duarte, Marta Maria Medeiros Frescura
Veit, Juliana Cristina
Somacal, Sabrina
Emanuelli, Tatiana
Grune, Tilman
Breusing, Nicolle
dc.subject.por.fl_str_mv Ácidos graxos
Homocisteína
Idoso
Comprometimento cognitivo leve
topic Ácidos graxos
Homocisteína
Idoso
Comprometimento cognitivo leve
Aging
Fatty acids
Cognitive decline
Homocysteine
dc.subject.eng.fl_str_mv Aging
Fatty acids
Cognitive decline
Homocysteine
description Polyunsaturated fatty acids (PUFAs), especially the n-3 series, are known for their protective effects. Considering that cardiovascular diseases are risk factors for dementia, which is common at aging, the aim of this study was to evaluate whether fatty acid status in the elderly was associated with cognitive function and cardiovascular risk. Forty-five elderly persons (age ≥60 years) were included and divided into two groups based on their Mini-Mental Status Examination score adjusted for educational level: the case group (n = 12) and the control group (n = 33). Serum fatty acid composition, homocysteine (Hcy), hs-CRP, lipid profile and different cognitive domains were evaluated. The case group, characterized by reduced cognitive performance, showed higher levels of 14:0, 16:0, 16:1n-7 fatty acids and lower levels of 22:0, 24:1n-9, 22:6n-3 (DHA) and total PUFAs compared to the control group (p < 0.05). The n-6/n-3 ratio was elevated in both study groups, whereas alterations in Hcy, hs-CRP and lipid profile were observed in the case group. Cognitive function was positively associated with the 24:1n-9, DHA and total n-3 PUFAs, while 14:0, 16:0 and 16:1n-7 fatty acids, the n-6/n-3 ratio and Hcy were inversely associated. In addition, n-3 PUFAs, particularly DHA, were inversely associated with cardiovascular risk, assessed by Hcy levels in the elderly.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2023-11-25T03:26:15Z
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/267615
dc.identifier.issn.pt_BR.fl_str_mv 2072-6643
dc.identifier.nrb.pt_BR.fl_str_mv 000944180
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Nutrients. Basel, Switzerland. Vol. 6, n. 9 (Sep. 2014), p. 3624-3640
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