Higher serum S100b and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia

• Autor(a) principal: Zanette, Simone de Azevedo
• Data de Publicação: 2014
• Outros Autores: Sarria, Jairo Alberto Dussán, Souza, Andressa de, Deitos, Alícia, Torres, Iraci Lucena da Silva, Caumo, Wolnei
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/110152
• topic: Fibromialgia; Proteínas S100; Fator neurotrófico derivado do encéfalo; Limiar da dor; Fibromyalgia; S100B; BDNF; Pain-pressure threshold; Central sensitization

Background: Fibromyalgia (FM) is conceptualized as a central sensitization (CS) condition, that presents high serum brain-derived neurotrophic factor (BDNF) and neuroglia activation. Although the S100B protein regulates neuroglia functions, it has been traditionally used as a proxy of central nervous system damage. However, neither BDNF nor S100B association with the clinical picture of FM has been elucidated. To explore their association with the pressure-pain threshold (PPT) in FM, we performed a cross-sectional study, including 56 females with confirmed FM aged 18–65 years. Linear regression models were used to adjust for potential confounding factors between serum BDNF, S100B and PPT. Results: Serum BDNF and S100B were correlated (Spearman’s Rho = 0.29). Serum BDNF (log) and S100B (log) were correlated with the PPT (log) (Partial η2 = 0.129, P = 0.012 for the BDNF (log), and Partial η2 = 0.105, P = 0.025 for the S100B (log)). Serum BDNF (log) was inversely associated with PPT (log) (β = −1.01, SE = 0.41), age (β = −0.02, SE = 0.15) and obsessive compulsive disorder (β = −0.36, SE = 0.15), while serum S100B (log) was inversely associated with PPT (log) (β = −1.38, SE = 0.50), only. Conclusions: Both neuroglia key mediators in the CS process were inversely correlated with the PPT. Serum assessment of BDNF and S100B deserve further study to determine its potential as a proxy for the CS spectrum in FM.