Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/250421 |
Resumo: | Background: Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO2peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO2 peak) also have shorter telomeres. However, the effects of AERO on telomere length in patients with HFrEF are still unknown. In an attempt to fill this gap, we designed a study to determine the effects of 16 weeks of aerobic training (32 sessions) on telomere length in HFrEF patients. Methods: In this single-center randomized controlled trial, men and women between 50 and 80 years old will be allocated into two different groups: a moderate-intensity aerobic training and a control grouTelomere length, functional capacity, echocardiographic variables, endothelial function, and walking ability will be assessed before and after the 16-week intervention period. Discussion: Understanding the role of physical exercise in biological aging in HFrEF patients is relevant. Due to cell senescence, these individuals have shown a shorter telomere length. AERO can delay biological aging according to a balance in oxidative stress through antioxidant action. Positive telomere length results are expected for the aerobic training group. |
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Franzoni, Leandro TolfoGarcia, Eduardo LimaMotta, Stephanie Bastos daAhner, Mabel MarcielaBertoletti, Otavio AzevedoSaffi, Marco Aurélio LumertzSilveira, Anderson Donelli daPereira, Alexandre A.Pereira, Adamastor HumbertoDanzmann, Luiz CláudioStein, Ricardo2022-10-27T04:50:16Z20221745-6215http://hdl.handle.net/10183/250421001152428Background: Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO2peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO2 peak) also have shorter telomeres. However, the effects of AERO on telomere length in patients with HFrEF are still unknown. In an attempt to fill this gap, we designed a study to determine the effects of 16 weeks of aerobic training (32 sessions) on telomere length in HFrEF patients. Methods: In this single-center randomized controlled trial, men and women between 50 and 80 years old will be allocated into two different groups: a moderate-intensity aerobic training and a control grouTelomere length, functional capacity, echocardiographic variables, endothelial function, and walking ability will be assessed before and after the 16-week intervention period. Discussion: Understanding the role of physical exercise in biological aging in HFrEF patients is relevant. Due to cell senescence, these individuals have shown a shorter telomere length. AERO can delay biological aging according to a balance in oxidative stress through antioxidant action. Positive telomere length results are expected for the aerobic training group.application/pdfengTrials. [London]. Vol. 23 (2022), 283, 9 p.Exercício físicoReabilitação cardíacaInsuficiência cardíacaCapacidade residual funcionalEnvelhecimentoEndotélioExercise trainingCardiac rehabilitationHeart failureFunctional capacityBiological agingEndotheliumAerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trialEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001152428.pdf.txt001152428.pdf.txtExtracted Texttext/plain38258http://www.lume.ufrgs.br/bitstream/10183/250421/2/001152428.pdf.txt7e051ce669d51cf4519a00998da92e7aMD52ORIGINAL001152428.pdfTexto completo (inglês)application/pdf1055695http://www.lume.ufrgs.br/bitstream/10183/250421/1/001152428.pdfcabb735aa96b7880f8a5636acd50f916MD5110183/2504212022-10-28 04:47:33.175094oai:www.lume.ufrgs.br:10183/250421Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-10-28T07:47:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
title |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
spellingShingle |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial Franzoni, Leandro Tolfo Exercício físico Reabilitação cardíaca Insuficiência cardíaca Capacidade residual funcional Envelhecimento Endotélio Exercise training Cardiac rehabilitation Heart failure Functional capacity Biological aging Endothelium |
title_short |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
title_full |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
title_fullStr |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
title_full_unstemmed |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
title_sort |
Aerobic exercise and telomere length in patients with systolic heart failure : protocol study for a randomized controlled trial |
author |
Franzoni, Leandro Tolfo |
author_facet |
Franzoni, Leandro Tolfo Garcia, Eduardo Lima Motta, Stephanie Bastos da Ahner, Mabel Marciela Bertoletti, Otavio Azevedo Saffi, Marco Aurélio Lumertz Silveira, Anderson Donelli da Pereira, Alexandre A. Pereira, Adamastor Humberto Danzmann, Luiz Cláudio Stein, Ricardo |
author_role |
author |
author2 |
Garcia, Eduardo Lima Motta, Stephanie Bastos da Ahner, Mabel Marciela Bertoletti, Otavio Azevedo Saffi, Marco Aurélio Lumertz Silveira, Anderson Donelli da Pereira, Alexandre A. Pereira, Adamastor Humberto Danzmann, Luiz Cláudio Stein, Ricardo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Franzoni, Leandro Tolfo Garcia, Eduardo Lima Motta, Stephanie Bastos da Ahner, Mabel Marciela Bertoletti, Otavio Azevedo Saffi, Marco Aurélio Lumertz Silveira, Anderson Donelli da Pereira, Alexandre A. Pereira, Adamastor Humberto Danzmann, Luiz Cláudio Stein, Ricardo |
dc.subject.por.fl_str_mv |
Exercício físico Reabilitação cardíaca Insuficiência cardíaca Capacidade residual funcional Envelhecimento Endotélio |
topic |
Exercício físico Reabilitação cardíaca Insuficiência cardíaca Capacidade residual funcional Envelhecimento Endotélio Exercise training Cardiac rehabilitation Heart failure Functional capacity Biological aging Endothelium |
dc.subject.eng.fl_str_mv |
Exercise training Cardiac rehabilitation Heart failure Functional capacity Biological aging Endothelium |
description |
Background: Heart failure (HF) with reduced ejection fraction (HFrEF) is a syndrome that leads to fatigue and reduced functional capacity due to disease-related pathophysiological mechanisms. Aerobic exercise (AERO) plays a key role in improving HF outcomes, such as an increase in peak oxygen uptake (VO2peak). In addition, HF promotes cell senescence, which involves reducing telomere length. Several studies have shown that patients with a worse prognosis (i.e., reduced VO2 peak) also have shorter telomeres. However, the effects of AERO on telomere length in patients with HFrEF are still unknown. In an attempt to fill this gap, we designed a study to determine the effects of 16 weeks of aerobic training (32 sessions) on telomere length in HFrEF patients. Methods: In this single-center randomized controlled trial, men and women between 50 and 80 years old will be allocated into two different groups: a moderate-intensity aerobic training and a control grouTelomere length, functional capacity, echocardiographic variables, endothelial function, and walking ability will be assessed before and after the 16-week intervention period. Discussion: Understanding the role of physical exercise in biological aging in HFrEF patients is relevant. Due to cell senescence, these individuals have shown a shorter telomere length. AERO can delay biological aging according to a balance in oxidative stress through antioxidant action. Positive telomere length results are expected for the aerobic training group. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-10-27T04:50:16Z |
dc.date.issued.fl_str_mv |
2022 |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/250421 |
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1745-6215 |
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001152428 |
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http://hdl.handle.net/10183/250421 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Trials. [London]. Vol. 23 (2022), 283, 9 p. |
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openAccess |
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