Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes

Detalhes bibliográficos
Autor(a) principal: Fujihara, Fernanda Mari Fagundes
Data de Publicação: 2020
Outros Autores: Mello, Paulo Augusto de Arruda, Lindenmeyer, Rodrigo Leivas, Pakter, Helena Messinger, Lavinsky, Jacó, Benfica, Camila Zanella, Castoldi, Nedio, Picetti, Egidio, Lavinsky, Daniel, Finkelsztejn, Alessandro, Lavinsky, Fábio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/213653
Resumo: Purpose: To evaluate differences in the thickness of the individual macular layers between early, moderate, and severe glaucomatous eyes and compare them with healthy controls. Patients and Methods: Subjects with glaucoma presenting typical optic nerve head findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. All participants underwent 24–2 perimetry and spectral-domain OCT. Patients were divided into three groups (early, moderate, and severe) based on the mean deviation of the VF and a healthy control group. The device segmented the layers automatically, and their measurements were plotted using the means of the sectors of the inner (3mm) and outer (6mm) circles of the ETDRS grid. Results: A total of 109 eyes qualified for the study: 14 in the control group and 52, 18 and 25 in the early, moderate and severe groups, respectively. Mean age was 66.13 (SD=12.38). The mean thickness of the circumpapillary retinal nerve fiber layer (RNFL), total macular thickness (TMT), macular RNFL, ganglion cell layer (GCL) and inner plexiform layer (IPL) were significantly different between the 4 groups, with progressive decrease in thickness. Significant overall difference was found for the inner nuclear layer (INL), and the severe glaucoma group presented thicker measurements than controls and early glaucoma. Outer nuclear layer (ONL) was thinner in severe glaucoma group compared with early glaucoma group. Conclusion: Individual macular layer measurement using the inner and outer circles of the ETDRS grid is useful to evaluate different stages of glaucoma. The INL thickening and ONL thinning in advanced glaucoma should be explored in the future studies.
id UFRGS-2_2fa1a2a1be19a4da31399d8dc01e014a
oai_identifier_str oai:www.lume.ufrgs.br:10183/213653
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Fujihara, Fernanda Mari FagundesMello, Paulo Augusto de ArrudaLindenmeyer, Rodrigo LeivasPakter, Helena MessingerLavinsky, JacóBenfica, Camila ZanellaCastoldi, NedioPicetti, EgidioLavinsky, DanielFinkelsztejn, AlessandroLavinsky, Fábio2020-09-23T04:02:31Z20201177-5483http://hdl.handle.net/10183/213653001116434Purpose: To evaluate differences in the thickness of the individual macular layers between early, moderate, and severe glaucomatous eyes and compare them with healthy controls. Patients and Methods: Subjects with glaucoma presenting typical optic nerve head findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. All participants underwent 24–2 perimetry and spectral-domain OCT. Patients were divided into three groups (early, moderate, and severe) based on the mean deviation of the VF and a healthy control group. The device segmented the layers automatically, and their measurements were plotted using the means of the sectors of the inner (3mm) and outer (6mm) circles of the ETDRS grid. Results: A total of 109 eyes qualified for the study: 14 in the control group and 52, 18 and 25 in the early, moderate and severe groups, respectively. Mean age was 66.13 (SD=12.38). The mean thickness of the circumpapillary retinal nerve fiber layer (RNFL), total macular thickness (TMT), macular RNFL, ganglion cell layer (GCL) and inner plexiform layer (IPL) were significantly different between the 4 groups, with progressive decrease in thickness. Significant overall difference was found for the inner nuclear layer (INL), and the severe glaucoma group presented thicker measurements than controls and early glaucoma. Outer nuclear layer (ONL) was thinner in severe glaucoma group compared with early glaucoma group. Conclusion: Individual macular layer measurement using the inner and outer circles of the ETDRS grid is useful to evaluate different stages of glaucoma. The INL thickening and ONL thinning in advanced glaucoma should be explored in the future studies.application/pdfengClinical ophthalmology. Auckland. Vol. 14 (2020), p. 1591–1599GlaucomaNervo ópticoTomografia de coerência ópticaMácula lúteaDoencas retinianasCampos visuaisGlaucomaOptical coherence tomographyMaculaOptic nerveVisual fieldIndividual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyesEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001116434.pdf.txt001116434.pdf.txtExtracted Texttext/plain43903http://www.lume.ufrgs.br/bitstream/10183/213653/2/001116434.pdf.txta5648ad3a22ae70f7901bf7027171cc9MD52ORIGINAL001116434.pdfTexto completo (inglês)application/pdf2592949http://www.lume.ufrgs.br/bitstream/10183/213653/1/001116434.pdfbe47d02cf268432ca3874b46961ee78dMD5110183/2136532020-09-24 04:00:59.824901oai:www.lume.ufrgs.br:10183/213653Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-09-24T07:00:59Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
title Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
spellingShingle Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
Fujihara, Fernanda Mari Fagundes
Glaucoma
Nervo óptico
Tomografia de coerência óptica
Mácula lútea
Doencas retinianas
Campos visuais
Glaucoma
Optical coherence tomography
Macula
Optic nerve
Visual field
title_short Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
title_full Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
title_fullStr Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
title_full_unstemmed Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
title_sort Individual macular layer evaluation with spectral domain optical coherence tomography in normal and glaucomatous eyes
author Fujihara, Fernanda Mari Fagundes
author_facet Fujihara, Fernanda Mari Fagundes
Mello, Paulo Augusto de Arruda
Lindenmeyer, Rodrigo Leivas
Pakter, Helena Messinger
Lavinsky, Jacó
Benfica, Camila Zanella
Castoldi, Nedio
Picetti, Egidio
Lavinsky, Daniel
Finkelsztejn, Alessandro
Lavinsky, Fábio
author_role author
author2 Mello, Paulo Augusto de Arruda
Lindenmeyer, Rodrigo Leivas
Pakter, Helena Messinger
Lavinsky, Jacó
Benfica, Camila Zanella
Castoldi, Nedio
Picetti, Egidio
Lavinsky, Daniel
Finkelsztejn, Alessandro
Lavinsky, Fábio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fujihara, Fernanda Mari Fagundes
Mello, Paulo Augusto de Arruda
Lindenmeyer, Rodrigo Leivas
Pakter, Helena Messinger
Lavinsky, Jacó
Benfica, Camila Zanella
Castoldi, Nedio
Picetti, Egidio
Lavinsky, Daniel
Finkelsztejn, Alessandro
Lavinsky, Fábio
dc.subject.por.fl_str_mv Glaucoma
Nervo óptico
Tomografia de coerência óptica
Mácula lútea
Doencas retinianas
Campos visuais
topic Glaucoma
Nervo óptico
Tomografia de coerência óptica
Mácula lútea
Doencas retinianas
Campos visuais
Glaucoma
Optical coherence tomography
Macula
Optic nerve
Visual field
dc.subject.eng.fl_str_mv Glaucoma
Optical coherence tomography
Macula
Optic nerve
Visual field
description Purpose: To evaluate differences in the thickness of the individual macular layers between early, moderate, and severe glaucomatous eyes and compare them with healthy controls. Patients and Methods: Subjects with glaucoma presenting typical optic nerve head findings, high intraocular pressure with or without visual field (VF) damage and normal controls were included. All participants underwent 24–2 perimetry and spectral-domain OCT. Patients were divided into three groups (early, moderate, and severe) based on the mean deviation of the VF and a healthy control group. The device segmented the layers automatically, and their measurements were plotted using the means of the sectors of the inner (3mm) and outer (6mm) circles of the ETDRS grid. Results: A total of 109 eyes qualified for the study: 14 in the control group and 52, 18 and 25 in the early, moderate and severe groups, respectively. Mean age was 66.13 (SD=12.38). The mean thickness of the circumpapillary retinal nerve fiber layer (RNFL), total macular thickness (TMT), macular RNFL, ganglion cell layer (GCL) and inner plexiform layer (IPL) were significantly different between the 4 groups, with progressive decrease in thickness. Significant overall difference was found for the inner nuclear layer (INL), and the severe glaucoma group presented thicker measurements than controls and early glaucoma. Outer nuclear layer (ONL) was thinner in severe glaucoma group compared with early glaucoma group. Conclusion: Individual macular layer measurement using the inner and outer circles of the ETDRS grid is useful to evaluate different stages of glaucoma. The INL thickening and ONL thinning in advanced glaucoma should be explored in the future studies.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-09-23T04:02:31Z
dc.date.issued.fl_str_mv 2020
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/213653
dc.identifier.issn.pt_BR.fl_str_mv 1177-5483
dc.identifier.nrb.pt_BR.fl_str_mv 001116434
identifier_str_mv 1177-5483
001116434
url http://hdl.handle.net/10183/213653
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Clinical ophthalmology. Auckland. Vol. 14 (2020), p. 1591–1599
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/213653/2/001116434.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/213653/1/001116434.pdf
bitstream.checksum.fl_str_mv a5648ad3a22ae70f7901bf7027171cc9
be47d02cf268432ca3874b46961ee78d
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1815447719862337536