The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/89718 |
Resumo: | Capsaicin, a topical analgesic used in the treatment of chronic pain, has irritant properties that frequently interrupt its use. In this work, the effect of nanoencapsulation of the main capsaicinoids (capsaicin and dihydrocapsaicin) on skin irritation was tested in humans. Skin tolerance of a novel vehicle composed of chitosan hydrogel containing nonloaded nanocapsules (CH-NC) was also evaluated. The chitosan hydrogel containing nanoencapsulated capsaicinoids (CH-NC-CP) did not cause skin irritation, as measured by an erythema probe and on a visual scale, while a formulation containing free capsaicinoids (chitosan gel with hydroalcoholic solution [CH-ET-CP]) and a commercially available capsaicinoids formulation caused skin irritation. Thirty-one percent of volunteers reported slight irritation one hour after application of CH-NC-CP, while moderate (46% [CH-ET-CP] and 23% [commercial product]) and severe (8% [CH-ET-CP] and 69% [commercial product]) irritation were described for the formulations containing free capsaicinoids. When CH-NC was applied to the skin, erythema was not observed and only 8% of volunteers felt slight irritation, which demonstrates the utility of the novel vehicle. A complementary in vitro skin permeation study showed that permeation of capsaicinoids through an epidermal human membrane was reduced but not prevented by nanoencapsulation. |
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Contri, Renata VidorFrank, Luiza AbrahãoKaiser, MoacirPohlmann, Adriana RaffinGuterres, Silvia Stanisçuaski2014-03-26T01:51:14Z20141178-2013http://hdl.handle.net/10183/89718000912068Capsaicin, a topical analgesic used in the treatment of chronic pain, has irritant properties that frequently interrupt its use. In this work, the effect of nanoencapsulation of the main capsaicinoids (capsaicin and dihydrocapsaicin) on skin irritation was tested in humans. Skin tolerance of a novel vehicle composed of chitosan hydrogel containing nonloaded nanocapsules (CH-NC) was also evaluated. The chitosan hydrogel containing nanoencapsulated capsaicinoids (CH-NC-CP) did not cause skin irritation, as measured by an erythema probe and on a visual scale, while a formulation containing free capsaicinoids (chitosan gel with hydroalcoholic solution [CH-ET-CP]) and a commercially available capsaicinoids formulation caused skin irritation. Thirty-one percent of volunteers reported slight irritation one hour after application of CH-NC-CP, while moderate (46% [CH-ET-CP] and 23% [commercial product]) and severe (8% [CH-ET-CP] and 69% [commercial product]) irritation were described for the formulations containing free capsaicinoids. When CH-NC was applied to the skin, erythema was not observed and only 8% of volunteers felt slight irritation, which demonstrates the utility of the novel vehicle. A complementary in vitro skin permeation study showed that permeation of capsaicinoids through an epidermal human membrane was reduced but not prevented by nanoencapsulation.application/pdfengInternational Journal of Nanomedicine. Auckland. Vol. 9, no. 1 (Feb. 2014), p. 951-962NanocápsulasQuitosanaChitosanNanocapsulesCapsaicinoidsSkin irritationSkin permeationThe use of nanoencapsulation to decrease human skin irritation caused by capsaicinoidsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000912068.pdf000912068.pdfTexto completo (inglês)application/pdf754967http://www.lume.ufrgs.br/bitstream/10183/89718/1/000912068.pdf60d5fa4cb95f09d3793c649ba1642038MD51TEXT000912068.pdf.txt000912068.pdf.txtExtracted Texttext/plain54200http://www.lume.ufrgs.br/bitstream/10183/89718/2/000912068.pdf.txtd1c3f73bc6dd4aadee1035176c1e91c7MD52THUMBNAIL000912068.pdf.jpg000912068.pdf.jpgGenerated Thumbnailimage/jpeg1822http://www.lume.ufrgs.br/bitstream/10183/89718/3/000912068.pdf.jpg66406f2288c1fdde0b8b5fd7b7aa4f74MD5310183/897182019-12-28 05:00:01.926272oai:www.lume.ufrgs.br:10183/89718Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-12-28T07:00:01Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
title |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
spellingShingle |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids Contri, Renata Vidor Nanocápsulas Quitosana Chitosan Nanocapsules Capsaicinoids Skin irritation Skin permeation |
title_short |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
title_full |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
title_fullStr |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
title_full_unstemmed |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
title_sort |
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids |
author |
Contri, Renata Vidor |
author_facet |
Contri, Renata Vidor Frank, Luiza Abrahão Kaiser, Moacir Pohlmann, Adriana Raffin Guterres, Silvia Stanisçuaski |
author_role |
author |
author2 |
Frank, Luiza Abrahão Kaiser, Moacir Pohlmann, Adriana Raffin Guterres, Silvia Stanisçuaski |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Contri, Renata Vidor Frank, Luiza Abrahão Kaiser, Moacir Pohlmann, Adriana Raffin Guterres, Silvia Stanisçuaski |
dc.subject.por.fl_str_mv |
Nanocápsulas Quitosana |
topic |
Nanocápsulas Quitosana Chitosan Nanocapsules Capsaicinoids Skin irritation Skin permeation |
dc.subject.eng.fl_str_mv |
Chitosan Nanocapsules Capsaicinoids Skin irritation Skin permeation |
description |
Capsaicin, a topical analgesic used in the treatment of chronic pain, has irritant properties that frequently interrupt its use. In this work, the effect of nanoencapsulation of the main capsaicinoids (capsaicin and dihydrocapsaicin) on skin irritation was tested in humans. Skin tolerance of a novel vehicle composed of chitosan hydrogel containing nonloaded nanocapsules (CH-NC) was also evaluated. The chitosan hydrogel containing nanoencapsulated capsaicinoids (CH-NC-CP) did not cause skin irritation, as measured by an erythema probe and on a visual scale, while a formulation containing free capsaicinoids (chitosan gel with hydroalcoholic solution [CH-ET-CP]) and a commercially available capsaicinoids formulation caused skin irritation. Thirty-one percent of volunteers reported slight irritation one hour after application of CH-NC-CP, while moderate (46% [CH-ET-CP] and 23% [commercial product]) and severe (8% [CH-ET-CP] and 69% [commercial product]) irritation were described for the formulations containing free capsaicinoids. When CH-NC was applied to the skin, erythema was not observed and only 8% of volunteers felt slight irritation, which demonstrates the utility of the novel vehicle. A complementary in vitro skin permeation study showed that permeation of capsaicinoids through an epidermal human membrane was reduced but not prevented by nanoencapsulation. |
publishDate |
2014 |
dc.date.accessioned.fl_str_mv |
2014-03-26T01:51:14Z |
dc.date.issued.fl_str_mv |
2014 |
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Estrangeiro info:eu-repo/semantics/article |
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1178-2013 |
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000912068 |
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http://hdl.handle.net/10183/89718 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International Journal of Nanomedicine. Auckland. Vol. 9, no. 1 (Feb. 2014), p. 951-962 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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