A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/110033 |
Resumo: | Background: Circadian theories for major depressive disorder have suggested that the rhythm of the circadian pacemaker is misaligned. Stable phase relationships between internal rhythms, such as temperature and rest/activity, and the external day-night cycle, are considered to be crucial for adapting to life in the external environmental. Therefore, the relationship and possible alterations among (i) light exposure, (ii) activity rhythm, and (iii) temperature rhythm could be important factors in clinical depression. This study aimed to investigate the rhythmic alterations in depression and evaluate the ability of chronobiological parameters to discriminate between healthy subjects and depressed patients. Methods: Thirty female subjects, including healthy subjects, depressed patients in the first episode, and major recurrent depression patients. Symptoms were assessed using Hamilton Depression Scale, Beck Depression Inventory and Montgomery-Äsberg Scale. Motor activity, temperature, and light values were determined for 7 days by actigraph, and circadian rhythms were calculated. Results: Depressed groups showed a lower amplitude in the circadian rhythm of activity and light exposure, but a higher amplitude in the rhythm of peripheral temperature. The correlation between temperature and activity values was different in the day and night among the control and depressed groups. For the same level of activity, depressed patients had lowest temperature values during the day. The amplitudes of temperature and activity were the highest discriminant parameters. Conclusions: These results indicate that the study of rhythms is useful for diagnosis and therapy for depressive mood disorders. |
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Moraes, Cláudia ÁvilaCambras, TrinitatDiez-Noguera, AntoniSchimitt, Regina LopesDantas, GiovanaLevandovski, Rosa MariaHidalgo, Maria Paz Loayza2015-02-12T02:15:09Z20131471-244Xhttp://hdl.handle.net/10183/110033000877871Background: Circadian theories for major depressive disorder have suggested that the rhythm of the circadian pacemaker is misaligned. Stable phase relationships between internal rhythms, such as temperature and rest/activity, and the external day-night cycle, are considered to be crucial for adapting to life in the external environmental. Therefore, the relationship and possible alterations among (i) light exposure, (ii) activity rhythm, and (iii) temperature rhythm could be important factors in clinical depression. This study aimed to investigate the rhythmic alterations in depression and evaluate the ability of chronobiological parameters to discriminate between healthy subjects and depressed patients. Methods: Thirty female subjects, including healthy subjects, depressed patients in the first episode, and major recurrent depression patients. Symptoms were assessed using Hamilton Depression Scale, Beck Depression Inventory and Montgomery-Äsberg Scale. Motor activity, temperature, and light values were determined for 7 days by actigraph, and circadian rhythms were calculated. Results: Depressed groups showed a lower amplitude in the circadian rhythm of activity and light exposure, but a higher amplitude in the rhythm of peripheral temperature. The correlation between temperature and activity values was different in the day and night among the control and depressed groups. For the same level of activity, depressed patients had lowest temperature values during the day. The amplitudes of temperature and activity were the highest discriminant parameters. Conclusions: These results indicate that the study of rhythms is useful for diagnosis and therapy for depressive mood disorders.application/pdfengBMC psychiatry. London. Vol. 13 (Mar. 2013), 77, 10 p.DepressãoTemperatura ambienteLuzRitmo circadianoDepressionTemperatureActivityLightCircadian rhythmA new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parametersEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000877871.pdf000877871.pdfTexto completo (inglês)application/pdf652453http://www.lume.ufrgs.br/bitstream/10183/110033/1/000877871.pdfafc88a650f86d2195f0aa0a8e63f4a53MD51TEXT000877871.pdf.txt000877871.pdf.txtExtracted Texttext/plain42300http://www.lume.ufrgs.br/bitstream/10183/110033/2/000877871.pdf.txt988e88e5b305db01b2e7537fd517b374MD52THUMBNAIL000877871.pdf.jpg000877871.pdf.jpgGenerated Thumbnailimage/jpeg1932http://www.lume.ufrgs.br/bitstream/10183/110033/3/000877871.pdf.jpg2d5279bb4cf17d8f51470493e7f8f807MD5310183/1100332021-03-09 04:44:40.249462oai:www.lume.ufrgs.br:10183/110033Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-03-09T07:44:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
title |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
spellingShingle |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters Moraes, Cláudia Ávila Depressão Temperatura ambiente Luz Ritmo circadiano Depression Temperature Activity Light Circadian rhythm |
title_short |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
title_full |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
title_fullStr |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
title_full_unstemmed |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
title_sort |
A new chronobiological approach to discriminate between acute and chronic depression using peripheral temperature, rest-activity, and light exposure parameters |
author |
Moraes, Cláudia Ávila |
author_facet |
Moraes, Cláudia Ávila Cambras, Trinitat Diez-Noguera, Antoni Schimitt, Regina Lopes Dantas, Giovana Levandovski, Rosa Maria Hidalgo, Maria Paz Loayza |
author_role |
author |
author2 |
Cambras, Trinitat Diez-Noguera, Antoni Schimitt, Regina Lopes Dantas, Giovana Levandovski, Rosa Maria Hidalgo, Maria Paz Loayza |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Moraes, Cláudia Ávila Cambras, Trinitat Diez-Noguera, Antoni Schimitt, Regina Lopes Dantas, Giovana Levandovski, Rosa Maria Hidalgo, Maria Paz Loayza |
dc.subject.por.fl_str_mv |
Depressão Temperatura ambiente Luz Ritmo circadiano |
topic |
Depressão Temperatura ambiente Luz Ritmo circadiano Depression Temperature Activity Light Circadian rhythm |
dc.subject.eng.fl_str_mv |
Depression Temperature Activity Light Circadian rhythm |
description |
Background: Circadian theories for major depressive disorder have suggested that the rhythm of the circadian pacemaker is misaligned. Stable phase relationships between internal rhythms, such as temperature and rest/activity, and the external day-night cycle, are considered to be crucial for adapting to life in the external environmental. Therefore, the relationship and possible alterations among (i) light exposure, (ii) activity rhythm, and (iii) temperature rhythm could be important factors in clinical depression. This study aimed to investigate the rhythmic alterations in depression and evaluate the ability of chronobiological parameters to discriminate between healthy subjects and depressed patients. Methods: Thirty female subjects, including healthy subjects, depressed patients in the first episode, and major recurrent depression patients. Symptoms were assessed using Hamilton Depression Scale, Beck Depression Inventory and Montgomery-Äsberg Scale. Motor activity, temperature, and light values were determined for 7 days by actigraph, and circadian rhythms were calculated. Results: Depressed groups showed a lower amplitude in the circadian rhythm of activity and light exposure, but a higher amplitude in the rhythm of peripheral temperature. The correlation between temperature and activity values was different in the day and night among the control and depressed groups. For the same level of activity, depressed patients had lowest temperature values during the day. The amplitudes of temperature and activity were the highest discriminant parameters. Conclusions: These results indicate that the study of rhythms is useful for diagnosis and therapy for depressive mood disorders. |
publishDate |
2013 |
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2013 |
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2015-02-12T02:15:09Z |
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000877871 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
BMC psychiatry. London. Vol. 13 (Mar. 2013), 77, 10 p. |
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openAccess |
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