Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature

Detalhes bibliográficos
Autor(a) principal: Vettorazzi, Janete
Data de Publicação: 2018
Outros Autores: Valério, Edimárlei Gonsales, Faulhaber, Gustavo Adolpho Moreira, Perez, Amanda Vilaverde, Silva, Mariana Sbaraini da, Vettori, Daniela Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/188817
Resumo: Complement deficiencies are uncommon types of primary immunodeficiency. Necrotizing fasciitis is a rare complication in pregnancy characterized by soft tissue invasion and necrosis of the subcutaneous and other adjacent tissues, leading to high mortality rates. We report a case of a 29-year-old pregnant woman with functional deficiency of the C4 complement component and short uterine cervix. Admitted at the hospital with preterm labor, she received multiple doses of immunoglobulin. After 8 weeks, she had a premature membrane rupture, and due to pelvic presentation she had a cesarean. The patient presented multiple obstetric complications, such as operative wound infection, endometritis, sepsis, necrotizing fasciitis and pelvic septic thrombophlebitis. She underwent multiple antimicrobial schemes, a hysterectomy and 4 extensive debridements of the abdominal wall because of significant necrosis. She stayed at the hospital for 101 days (32 of those in ICU in immediate postpartum). 41 days after cesarean, patient was discharged in good conditions. Our case emphasizes individual handling and high multiple doses of immunoglobulin for favorable outcome of the case.
id UFRGS-2_33dac2e729d671681a9583163786e81b
oai_identifier_str oai:www.lume.ufrgs.br:10183/188817
network_acronym_str UFRGS-2
network_name_str Repositório Institucional da UFRGS
repository_id_str
spelling Vettorazzi, JaneteValério, Edimárlei GonsalesFaulhaber, Gustavo Adolpho MoreiraPerez, Amanda VilaverdeSilva, Mariana Sbaraini daVettori, Daniela Vanessa2019-02-15T02:33:50Z20182160-8806http://hdl.handle.net/10183/188817001084865Complement deficiencies are uncommon types of primary immunodeficiency. Necrotizing fasciitis is a rare complication in pregnancy characterized by soft tissue invasion and necrosis of the subcutaneous and other adjacent tissues, leading to high mortality rates. We report a case of a 29-year-old pregnant woman with functional deficiency of the C4 complement component and short uterine cervix. Admitted at the hospital with preterm labor, she received multiple doses of immunoglobulin. After 8 weeks, she had a premature membrane rupture, and due to pelvic presentation she had a cesarean. The patient presented multiple obstetric complications, such as operative wound infection, endometritis, sepsis, necrotizing fasciitis and pelvic septic thrombophlebitis. She underwent multiple antimicrobial schemes, a hysterectomy and 4 extensive debridements of the abdominal wall because of significant necrosis. She stayed at the hospital for 101 days (32 of those in ICU in immediate postpartum). 41 days after cesarean, patient was discharged in good conditions. Our case emphasizes individual handling and high multiple doses of immunoglobulin for favorable outcome of the case.application/pdfengOpen Journal of Obstetrics and Gynecology. Irvine. vol. 8, no. 12 (2018), 88057, p. 1236-1246GravidezFasciite necrosanteImunidadePregnancyC4 FactorImmunodeficiencyC4 DeficiencyNecrotizing FasciitisPuerperal InfectionNecrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literatureEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001084865.pdf.txt001084865.pdf.txtExtracted Texttext/plain30321http://www.lume.ufrgs.br/bitstream/10183/188817/2/001084865.pdf.txt3c7901e487f92fb27fcecc5e65923da1MD52ORIGINAL001084865.pdfTexto completo (inglês)application/pdf726448http://www.lume.ufrgs.br/bitstream/10183/188817/1/001084865.pdf6f0abac0a42a6a2bfa9cf7adda0e436aMD5110183/1888172019-02-16 02:34:32.162257oai:www.lume.ufrgs.br:10183/188817Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-02-16T04:34:32Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
title Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
spellingShingle Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
Vettorazzi, Janete
Gravidez
Fasciite necrosante
Imunidade
Pregnancy
C4 Factor
Immunodeficiency
C4 Deficiency
Necrotizing Fasciitis
Puerperal Infection
title_short Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
title_full Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
title_fullStr Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
title_full_unstemmed Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
title_sort Necrotizing fasciitis in the puerperium of a woman with complement deficiency : case report and review literature
author Vettorazzi, Janete
author_facet Vettorazzi, Janete
Valério, Edimárlei Gonsales
Faulhaber, Gustavo Adolpho Moreira
Perez, Amanda Vilaverde
Silva, Mariana Sbaraini da
Vettori, Daniela Vanessa
author_role author
author2 Valério, Edimárlei Gonsales
Faulhaber, Gustavo Adolpho Moreira
Perez, Amanda Vilaverde
Silva, Mariana Sbaraini da
Vettori, Daniela Vanessa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vettorazzi, Janete
Valério, Edimárlei Gonsales
Faulhaber, Gustavo Adolpho Moreira
Perez, Amanda Vilaverde
Silva, Mariana Sbaraini da
Vettori, Daniela Vanessa
dc.subject.por.fl_str_mv Gravidez
Fasciite necrosante
Imunidade
topic Gravidez
Fasciite necrosante
Imunidade
Pregnancy
C4 Factor
Immunodeficiency
C4 Deficiency
Necrotizing Fasciitis
Puerperal Infection
dc.subject.eng.fl_str_mv Pregnancy
C4 Factor
Immunodeficiency
C4 Deficiency
Necrotizing Fasciitis
Puerperal Infection
description Complement deficiencies are uncommon types of primary immunodeficiency. Necrotizing fasciitis is a rare complication in pregnancy characterized by soft tissue invasion and necrosis of the subcutaneous and other adjacent tissues, leading to high mortality rates. We report a case of a 29-year-old pregnant woman with functional deficiency of the C4 complement component and short uterine cervix. Admitted at the hospital with preterm labor, she received multiple doses of immunoglobulin. After 8 weeks, she had a premature membrane rupture, and due to pelvic presentation she had a cesarean. The patient presented multiple obstetric complications, such as operative wound infection, endometritis, sepsis, necrotizing fasciitis and pelvic septic thrombophlebitis. She underwent multiple antimicrobial schemes, a hysterectomy and 4 extensive debridements of the abdominal wall because of significant necrosis. She stayed at the hospital for 101 days (32 of those in ICU in immediate postpartum). 41 days after cesarean, patient was discharged in good conditions. Our case emphasizes individual handling and high multiple doses of immunoglobulin for favorable outcome of the case.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-02-15T02:33:50Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/188817
dc.identifier.issn.pt_BR.fl_str_mv 2160-8806
dc.identifier.nrb.pt_BR.fl_str_mv 001084865
identifier_str_mv 2160-8806
001084865
url http://hdl.handle.net/10183/188817
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Open Journal of Obstetrics and Gynecology. Irvine. vol. 8, no. 12 (2018), 88057, p. 1236-1246
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
bitstream.url.fl_str_mv http://www.lume.ufrgs.br/bitstream/10183/188817/2/001084865.pdf.txt
http://www.lume.ufrgs.br/bitstream/10183/188817/1/001084865.pdf
bitstream.checksum.fl_str_mv 3c7901e487f92fb27fcecc5e65923da1
6f0abac0a42a6a2bfa9cf7adda0e436a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv
_version_ 1815447682513108992