Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/262332 |
Resumo: | Nisin is an antimicrobial peptide broadly used as a preservative in the food industry. In this study, oil-core polymeric nanocapsules encapsulating nisin were prepared by a nanoprecipitation technique using three different synthetic biodegradable polymers, namely poly(butylene adipate-coterephthalate) (PBAT), Eudragit RS-100® (EUD), and poly(ε-caprolactone) (PCL), and their physical characteristics, thermal resistance and antimicrobial activity against Listeria monocytogenes were investigated. All nanocapsule formulations showed entrapment efficiency superior to 96%. EUD and PCL nanocapsules showed average diameters ranging from 145 to 303 nm, while PBAT-nisin nanocapsules showed larger size and PDI index (556.2 nm and 0.51, respectively), possibly due to changes in the organic phase equilibrium during preparation. The thermogravimetric analysis indicates lower decomposition temperatures in the PCL and EUD nanocapsules containing nisin compared with the unload nanocapsule and the contrary effect in the PBAT. Moreover, all nisin-containing polymeric nanocapsules exhibited antimicrobial activity against L. monocytogenes in both agar diffusion tests and determination of antimicrobial units (AU/mL) in liquid media. Oil-core polymeric nanocapsules have not been previously described as carriers for nisin, and the results suggested that PBAT, EUD, and PCL could be suitable polymers for nisin delivery systems. |
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Pinilla, Cristian Mauricio BarretoIsaia, Henrique AtaideBrandelli, Adriano2023-07-19T03:38:28Z20232284-6808http://hdl.handle.net/10183/262332001168294Nisin is an antimicrobial peptide broadly used as a preservative in the food industry. In this study, oil-core polymeric nanocapsules encapsulating nisin were prepared by a nanoprecipitation technique using three different synthetic biodegradable polymers, namely poly(butylene adipate-coterephthalate) (PBAT), Eudragit RS-100® (EUD), and poly(ε-caprolactone) (PCL), and their physical characteristics, thermal resistance and antimicrobial activity against Listeria monocytogenes were investigated. All nanocapsule formulations showed entrapment efficiency superior to 96%. EUD and PCL nanocapsules showed average diameters ranging from 145 to 303 nm, while PBAT-nisin nanocapsules showed larger size and PDI index (556.2 nm and 0.51, respectively), possibly due to changes in the organic phase equilibrium during preparation. The thermogravimetric analysis indicates lower decomposition temperatures in the PCL and EUD nanocapsules containing nisin compared with the unload nanocapsule and the contrary effect in the PBAT. Moreover, all nisin-containing polymeric nanocapsules exhibited antimicrobial activity against L. monocytogenes in both agar diffusion tests and determination of antimicrobial units (AU/mL) in liquid media. Oil-core polymeric nanocapsules have not been previously described as carriers for nisin, and the results suggested that PBAT, EUD, and PCL could be suitable polymers for nisin delivery systems.application/pdfengLetters in Applied NanoBioScience [recurso eletrônico]. Buscareste, Romênia. Vol. 12, no. 1 (2023), Article 18, 8 p.Atividade antimicrobianaNanocápsulas poliméricasNanotecnologiaNisinaPatógenos alimentaresAntimicrobialPolymeric nanocapsulesNanoprecipitationNisinFood pathogenDevelopment and characterization of innovative polymeric oil-core nanocarriers for nisin deliveryEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001168294.pdf.txt001168294.pdf.txtExtracted Texttext/plain26053http://www.lume.ufrgs.br/bitstream/10183/262332/2/001168294.pdf.txt7a8aac5629e1ec9d6bc04391f112ae54MD52ORIGINAL001168294.pdfTexto completoapplication/pdf335819http://www.lume.ufrgs.br/bitstream/10183/262332/1/001168294.pdf01083bb03af8b401d71773d742b7eb54MD5110183/2623322023-07-20 03:34:33.471395oai:www.lume.ufrgs.br:10183/262332Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-20T06:34:33Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
title |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
spellingShingle |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery Pinilla, Cristian Mauricio Barreto Atividade antimicrobiana Nanocápsulas poliméricas Nanotecnologia Nisina Patógenos alimentares Antimicrobial Polymeric nanocapsules Nanoprecipitation Nisin Food pathogen |
title_short |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
title_full |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
title_fullStr |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
title_full_unstemmed |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
title_sort |
Development and characterization of innovative polymeric oil-core nanocarriers for nisin delivery |
author |
Pinilla, Cristian Mauricio Barreto |
author_facet |
Pinilla, Cristian Mauricio Barreto Isaia, Henrique Ataide Brandelli, Adriano |
author_role |
author |
author2 |
Isaia, Henrique Ataide Brandelli, Adriano |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pinilla, Cristian Mauricio Barreto Isaia, Henrique Ataide Brandelli, Adriano |
dc.subject.por.fl_str_mv |
Atividade antimicrobiana Nanocápsulas poliméricas Nanotecnologia Nisina Patógenos alimentares |
topic |
Atividade antimicrobiana Nanocápsulas poliméricas Nanotecnologia Nisina Patógenos alimentares Antimicrobial Polymeric nanocapsules Nanoprecipitation Nisin Food pathogen |
dc.subject.eng.fl_str_mv |
Antimicrobial Polymeric nanocapsules Nanoprecipitation Nisin Food pathogen |
description |
Nisin is an antimicrobial peptide broadly used as a preservative in the food industry. In this study, oil-core polymeric nanocapsules encapsulating nisin were prepared by a nanoprecipitation technique using three different synthetic biodegradable polymers, namely poly(butylene adipate-coterephthalate) (PBAT), Eudragit RS-100® (EUD), and poly(ε-caprolactone) (PCL), and their physical characteristics, thermal resistance and antimicrobial activity against Listeria monocytogenes were investigated. All nanocapsule formulations showed entrapment efficiency superior to 96%. EUD and PCL nanocapsules showed average diameters ranging from 145 to 303 nm, while PBAT-nisin nanocapsules showed larger size and PDI index (556.2 nm and 0.51, respectively), possibly due to changes in the organic phase equilibrium during preparation. The thermogravimetric analysis indicates lower decomposition temperatures in the PCL and EUD nanocapsules containing nisin compared with the unload nanocapsule and the contrary effect in the PBAT. Moreover, all nisin-containing polymeric nanocapsules exhibited antimicrobial activity against L. monocytogenes in both agar diffusion tests and determination of antimicrobial units (AU/mL) in liquid media. Oil-core polymeric nanocapsules have not been previously described as carriers for nisin, and the results suggested that PBAT, EUD, and PCL could be suitable polymers for nisin delivery systems. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-07-19T03:38:28Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10183/262332 |
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2284-6808 |
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001168294 |
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http://hdl.handle.net/10183/262332 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Letters in Applied NanoBioScience [recurso eletrônico]. Buscareste, Romênia. Vol. 12, no. 1 (2023), Article 18, 8 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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