TBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy : a comparative study

• Autor(a) principal: Mardini, Victor
• Data de Publicação: 2017
• Outros Autores: Rohde, Luis Augusto Paim, Ceresér, Keila Maria Mendes, Gubert, Carolina de Moura, Silva, Emily Galvão da, Xavier , Fernando Antonio Costa, Parcianello, Rodrigo Ritter, Röhsig, Liane Marise, Pechansky, Flavio, Szobot, Claudia Maciel
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/181616
• topic: Fator neurotrófico derivado do encéfalo; Cocaína crack; Transtornos relacionados ao uso de cocaína; Sangue fetal; Gravidez; Substâncias reativas com ácido tiobarbitúrico; TBARS; BDNF; Pregnancy; Crack/cocaine; Umbilical cord blood; Newborn

Objectives: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and nonexposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed. Results: After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL, 95%CI 0.47-1.23; p o 0.001; Cohen effect size: 1.12), and significantly lower in crack/cocaine mothers than in control mothers (4.03 ng/mL, 95%CI 2.87-5.18 vs. 6.67 ng/mL, 95%CI 5.60-7.74; p = 0.006). The adjusted mean TBARS level was significantly lower in EN (63.97 mM MDA, 95%CI 39.43-88.50) than NEN (177.04 mM MDA, 95%CI 140.93-213.14; p o 0.001; effect size = 0.84), with no difference between mother groups (p = 0.86). Conclusions: The changes in TBARS levels observed in EN suggest that fetuses exposed to cocaine mobilize endogenous antioxidant routes since very early stages of development. The increase in BDNF levels in EN might indicate changes in fetal development, whereas the changes in BDNF levels in mothers provide evidence of the complex metabolic processes involved in drug use during pregnancy.