Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc

Detalhes bibliográficos
Autor(a) principal: Malesuik, Marcelo Donadel
Data de Publicação: 2010
Outros Autores: Paim, Clésio Soldateli, Steppe, Martin, Schapoval, Elfrides Eva Scherman
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/72886
Resumo: A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.
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spelling Malesuik, Marcelo DonadelPaim, Clésio SoldateliSteppe, MartinSchapoval, Elfrides Eva Scherman2013-07-02T01:43:22Z20100100-4042http://hdl.handle.net/10183/72886000753027A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.application/pdfengQuímica nova. São Paulo. Vol. 33, n. 3 (2010), p. 739-742NitazoxanidaValidação : Métodos de análise de fármacosNitazoxanideUV-spectrophotometryMethod validationDevelopment of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplcinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000753027.pdf000753027.pdfTexto completo (inglês)application/pdf167346http://www.lume.ufrgs.br/bitstream/10183/72886/1/000753027.pdfb2049d6cfcc366327155d57277f1085dMD51TEXT000753027.pdf.txt000753027.pdf.txtExtracted Texttext/plain19698http://www.lume.ufrgs.br/bitstream/10183/72886/2/000753027.pdf.txt0f7006d0e39ddda9ee127bc7d033163eMD52THUMBNAIL000753027.pdf.jpg000753027.pdf.jpgGenerated Thumbnailimage/jpeg1965http://www.lume.ufrgs.br/bitstream/10183/72886/3/000753027.pdf.jpg9cf6a4c32dfcf1547f541fffc4afc54eMD5310183/728862019-06-19 02:33:15.933762oai:www.lume.ufrgs.br:10183/72886Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-06-19T05:33:15Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
title Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
spellingShingle Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
Malesuik, Marcelo Donadel
Nitazoxanida
Validação : Métodos de análise de fármacos
Nitazoxanide
UV-spectrophotometry
Method validation
title_short Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
title_full Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
title_fullStr Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
title_full_unstemmed Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
title_sort Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
author Malesuik, Marcelo Donadel
author_facet Malesuik, Marcelo Donadel
Paim, Clésio Soldateli
Steppe, Martin
Schapoval, Elfrides Eva Scherman
author_role author
author2 Paim, Clésio Soldateli
Steppe, Martin
Schapoval, Elfrides Eva Scherman
author2_role author
author
author
dc.contributor.author.fl_str_mv Malesuik, Marcelo Donadel
Paim, Clésio Soldateli
Steppe, Martin
Schapoval, Elfrides Eva Scherman
dc.subject.por.fl_str_mv Nitazoxanida
Validação : Métodos de análise de fármacos
topic Nitazoxanida
Validação : Métodos de análise de fármacos
Nitazoxanide
UV-spectrophotometry
Method validation
dc.subject.eng.fl_str_mv Nitazoxanide
UV-spectrophotometry
Method validation
description A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-07-02T01:43:22Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/72886
dc.identifier.issn.pt_BR.fl_str_mv 0100-4042
dc.identifier.nrb.pt_BR.fl_str_mv 000753027
identifier_str_mv 0100-4042
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Química nova. São Paulo. Vol. 33, n. 3 (2010), p. 739-742
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