Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/158923 |
Resumo: | Emerging evidence suggests sex differences in the early origins of adult metabolic disease, but this has been little investigated in developing countries. We investigated sex-specific associations between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetes was defined by self-reported information and laboratory measurements. In confounder-adjusted analyses, LBW (vs. 2.5–4 kg) was associated with higher prevalence of diabetes in women (Prevalence Ratio (PR) 1.54, 95% CI: 1.32–1.79), not in men (PR 1.06, 95% CI: 0.91–1.25; Pheterogeneity = 0.003). The association was stronger among participants with maternal diabetes (PR 1.60, 95% CI: 1.35–1.91), than those without (PR 1.15, 95% CI: 0.99–1.32; Pheterogeneity = 0.03). When jointly stratified by sex and maternal diabetes, the association was observed for women with (PR 1.77, 95% CI: 1.37–2.29) and without (PR 1.45, 95% CI: 1.20–1.75) maternal diabetes. In contrast, in men, LBW was associated with diabetes in participants with maternal diabetes (PR 1.45, 95% CI: 1.15–1.83), but not in those without (PR 0.92, 95% CI: 0.74–1.14). These sex-specific findings extended to continuous measures of glucose homeostasis. LBW was associated with higher diabetes prevalence in Brazilian women, and in men with maternal diabetes, suggesting sex-specific intrauterine effects on adult metabolic health. |
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Yarmolinsky, JamesMueller, Noel TheodoreDuncan, Bruce BartholowChor, DoraBenseñor, Isabela Judith MartinsGriep, Rosane HarterAppel, Lawrence J.Barreto, Sandhi MariaSchmidt, Maria Inês2017-06-01T02:36:05Z20162045-2322http://hdl.handle.net/10183/158923001013830Emerging evidence suggests sex differences in the early origins of adult metabolic disease, but this has been little investigated in developing countries. We investigated sex-specific associations between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetes was defined by self-reported information and laboratory measurements. In confounder-adjusted analyses, LBW (vs. 2.5–4 kg) was associated with higher prevalence of diabetes in women (Prevalence Ratio (PR) 1.54, 95% CI: 1.32–1.79), not in men (PR 1.06, 95% CI: 0.91–1.25; Pheterogeneity = 0.003). The association was stronger among participants with maternal diabetes (PR 1.60, 95% CI: 1.35–1.91), than those without (PR 1.15, 95% CI: 0.99–1.32; Pheterogeneity = 0.03). When jointly stratified by sex and maternal diabetes, the association was observed for women with (PR 1.77, 95% CI: 1.37–2.29) and without (PR 1.45, 95% CI: 1.20–1.75) maternal diabetes. In contrast, in men, LBW was associated with diabetes in participants with maternal diabetes (PR 1.45, 95% CI: 1.15–1.83), but not in those without (PR 0.92, 95% CI: 0.74–1.14). These sex-specific findings extended to continuous measures of glucose homeostasis. LBW was associated with higher diabetes prevalence in Brazilian women, and in men with maternal diabetes, suggesting sex-specific intrauterine effects on adult metabolic health.application/pdfengScientific reports. London. Vol. 6 (Nov. 2016), 37032, p. 1-9Peso ao nascerDiabetes mellitus tipo 2GlucoseHomeostaseSex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult HealthEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL001013830.pdf001013830.pdfTexto completo (inglês)application/pdf257802http://www.lume.ufrgs.br/bitstream/10183/158923/1/001013830.pdf529bba7b797307928fb355417e7ec9cfMD51TEXT001013830.pdf.txt001013830.pdf.txtExtracted Texttext/plain45669http://www.lume.ufrgs.br/bitstream/10183/158923/2/001013830.pdf.txt6a6975b50b5e5b5419a9c989e62da4d7MD5210183/1589232023-05-17 03:28:45.780533oai:www.lume.ufrgs.br:10183/158923Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-05-17T06:28:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
title |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
spellingShingle |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health Yarmolinsky, James Peso ao nascer Diabetes mellitus tipo 2 Glucose Homeostase |
title_short |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
title_full |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
title_fullStr |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
title_full_unstemmed |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
title_sort |
Sex-specific associations of low birth weight with adult-onset diabetes and measures of glucose homeostasis: Brazilian Longitudinal Study of Adult Health |
author |
Yarmolinsky, James |
author_facet |
Yarmolinsky, James Mueller, Noel Theodore Duncan, Bruce Bartholow Chor, Dora Benseñor, Isabela Judith Martins Griep, Rosane Harter Appel, Lawrence J. Barreto, Sandhi Maria Schmidt, Maria Inês |
author_role |
author |
author2 |
Mueller, Noel Theodore Duncan, Bruce Bartholow Chor, Dora Benseñor, Isabela Judith Martins Griep, Rosane Harter Appel, Lawrence J. Barreto, Sandhi Maria Schmidt, Maria Inês |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Yarmolinsky, James Mueller, Noel Theodore Duncan, Bruce Bartholow Chor, Dora Benseñor, Isabela Judith Martins Griep, Rosane Harter Appel, Lawrence J. Barreto, Sandhi Maria Schmidt, Maria Inês |
dc.subject.por.fl_str_mv |
Peso ao nascer Diabetes mellitus tipo 2 Glucose Homeostase |
topic |
Peso ao nascer Diabetes mellitus tipo 2 Glucose Homeostase |
description |
Emerging evidence suggests sex differences in the early origins of adult metabolic disease, but this has been little investigated in developing countries. We investigated sex-specific associations between low birth weight (LBW; <2.5 kg) and adult-onset diabetes in 12,525 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Diabetes was defined by self-reported information and laboratory measurements. In confounder-adjusted analyses, LBW (vs. 2.5–4 kg) was associated with higher prevalence of diabetes in women (Prevalence Ratio (PR) 1.54, 95% CI: 1.32–1.79), not in men (PR 1.06, 95% CI: 0.91–1.25; Pheterogeneity = 0.003). The association was stronger among participants with maternal diabetes (PR 1.60, 95% CI: 1.35–1.91), than those without (PR 1.15, 95% CI: 0.99–1.32; Pheterogeneity = 0.03). When jointly stratified by sex and maternal diabetes, the association was observed for women with (PR 1.77, 95% CI: 1.37–2.29) and without (PR 1.45, 95% CI: 1.20–1.75) maternal diabetes. In contrast, in men, LBW was associated with diabetes in participants with maternal diabetes (PR 1.45, 95% CI: 1.15–1.83), but not in those without (PR 0.92, 95% CI: 0.74–1.14). These sex-specific findings extended to continuous measures of glucose homeostasis. LBW was associated with higher diabetes prevalence in Brazilian women, and in men with maternal diabetes, suggesting sex-specific intrauterine effects on adult metabolic health. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
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2017-06-01T02:36:05Z |
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http://hdl.handle.net/10183/158923 |
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2045-2322 |
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001013830 |
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2045-2322 001013830 |
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http://hdl.handle.net/10183/158923 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 6 (Nov. 2016), 37032, p. 1-9 |
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