Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21546 |
Resumo: | Introduction The use of noninvasive positive-pressure mechanical ventilation (NPPV) has been investigated in several acute respiratory failure situations. Questions remain about its benefits when used in weaning patients from invasive mechanical ventilation (IMV). The objective of this study was to evaluate the use of bi-level NPPV for patients who fail weaning from IMV. Methods This experimental randomized clinical trial followed up patients undergoing IMV weaning, under ventilation for more than 48 hours, and who failed a spontaneous breathing T-piece trial. Patients with contraindications to NPPV were excluded. Before T-piece placement, arterial gases, maximal inspiratory pressure, and other parameters of IMV support were measured. During the trial, respiratory rate, tidal volume, minute volume, rapid shallow breathing index, heart rate, arterial blood pressure, and peripheral oxygen saturation were measured at 1 and 30 minutes. After failing a T-piece trial, patients were randomly divided in two groups: (a) those who were extubated and placed on NPPV and (b) those who were returned to IMV. Group results were compared using the Student t test and the chi-square test. Results Of 65 patients who failed T-piece trials, 28 were placed on NPPV and 37 were placed on IMV. The ages of patients in the NPPV and IMV groups were 67.6 ± 15.5 and 59.7 ± 17.6 years, respectively. Heart disease, post-surgery respiratory failure, and chronic pulmonary disease aggravation were the most frequent causes of IMV use. In both groups, ventilation time before T-piece trial was 7.3 ± 4.1 days. Heart and respiratory parameters were similar for the two groups at 1 and 30 minutes of T-piece trial. The percentage of complications in the NPPV group was lower (28.6% versus 75.7%), with lower incidences of pneumonia and tracheotomy. Length of stay in the intensive care unit and mortality were not statistically different when comparing the groups. Conclusion The results suggest that NPPV is a good alternative for ventilation of patients who fail initial weaning attempts. NPPV reduces the incidence of pneumonia associated with mechanical ventilation and the need for tracheotomy. |
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Trevisan, Cristiane Brenner EilertVieira, Silvia Regina Rios2010-05-05T04:15:48Z2008http://hdl.handle.net/10183/21546000643831Introduction The use of noninvasive positive-pressure mechanical ventilation (NPPV) has been investigated in several acute respiratory failure situations. Questions remain about its benefits when used in weaning patients from invasive mechanical ventilation (IMV). The objective of this study was to evaluate the use of bi-level NPPV for patients who fail weaning from IMV. Methods This experimental randomized clinical trial followed up patients undergoing IMV weaning, under ventilation for more than 48 hours, and who failed a spontaneous breathing T-piece trial. Patients with contraindications to NPPV were excluded. Before T-piece placement, arterial gases, maximal inspiratory pressure, and other parameters of IMV support were measured. During the trial, respiratory rate, tidal volume, minute volume, rapid shallow breathing index, heart rate, arterial blood pressure, and peripheral oxygen saturation were measured at 1 and 30 minutes. After failing a T-piece trial, patients were randomly divided in two groups: (a) those who were extubated and placed on NPPV and (b) those who were returned to IMV. Group results were compared using the Student t test and the chi-square test. Results Of 65 patients who failed T-piece trials, 28 were placed on NPPV and 37 were placed on IMV. The ages of patients in the NPPV and IMV groups were 67.6 ± 15.5 and 59.7 ± 17.6 years, respectively. Heart disease, post-surgery respiratory failure, and chronic pulmonary disease aggravation were the most frequent causes of IMV use. In both groups, ventilation time before T-piece trial was 7.3 ± 4.1 days. Heart and respiratory parameters were similar for the two groups at 1 and 30 minutes of T-piece trial. The percentage of complications in the NPPV group was lower (28.6% versus 75.7%), with lower incidences of pneumonia and tracheotomy. Length of stay in the intensive care unit and mortality were not statistically different when comparing the groups. Conclusion The results suggest that NPPV is a good alternative for ventilation of patients who fail initial weaning attempts. NPPV reduces the incidence of pneumonia associated with mechanical ventilation and the need for tracheotomy.application/pdfengCritical care. London. Vol. 12, no. 2 (Apr. 2008), p. 1-8Ventilação mecânicaNoninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trialEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000643831.pdf.txt000643831.pdf.txtExtracted Texttext/plain39745http://www.lume.ufrgs.br/bitstream/10183/21546/2/000643831.pdf.txt78b1379cb1c17c1bdab79676906b6c01MD52ORIGINAL000643831.pdfTexto completo (inglês)application/pdf301820http://www.lume.ufrgs.br/bitstream/10183/21546/1/000643831.pdf4872d7e6cb5c3b189a44e3862162b078MD5110183/215462021-06-26 04:47:06.64643oai:www.lume.ufrgs.br:10183/21546Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-06-26T07:47:06Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
title |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
spellingShingle |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial Trevisan, Cristiane Brenner Eilert Ventilação mecânica |
title_short |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
title_full |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
title_fullStr |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
title_full_unstemmed |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
title_sort |
Noninvasive mechanical ventilation may be useful in treating patients who fail weaning from invasive mechanical ventilation : a randomized clinical trial |
author |
Trevisan, Cristiane Brenner Eilert |
author_facet |
Trevisan, Cristiane Brenner Eilert Vieira, Silvia Regina Rios |
author_role |
author |
author2 |
Vieira, Silvia Regina Rios |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Trevisan, Cristiane Brenner Eilert Vieira, Silvia Regina Rios |
dc.subject.por.fl_str_mv |
Ventilação mecânica |
topic |
Ventilação mecânica |
description |
Introduction The use of noninvasive positive-pressure mechanical ventilation (NPPV) has been investigated in several acute respiratory failure situations. Questions remain about its benefits when used in weaning patients from invasive mechanical ventilation (IMV). The objective of this study was to evaluate the use of bi-level NPPV for patients who fail weaning from IMV. Methods This experimental randomized clinical trial followed up patients undergoing IMV weaning, under ventilation for more than 48 hours, and who failed a spontaneous breathing T-piece trial. Patients with contraindications to NPPV were excluded. Before T-piece placement, arterial gases, maximal inspiratory pressure, and other parameters of IMV support were measured. During the trial, respiratory rate, tidal volume, minute volume, rapid shallow breathing index, heart rate, arterial blood pressure, and peripheral oxygen saturation were measured at 1 and 30 minutes. After failing a T-piece trial, patients were randomly divided in two groups: (a) those who were extubated and placed on NPPV and (b) those who were returned to IMV. Group results were compared using the Student t test and the chi-square test. Results Of 65 patients who failed T-piece trials, 28 were placed on NPPV and 37 were placed on IMV. The ages of patients in the NPPV and IMV groups were 67.6 ± 15.5 and 59.7 ± 17.6 years, respectively. Heart disease, post-surgery respiratory failure, and chronic pulmonary disease aggravation were the most frequent causes of IMV use. In both groups, ventilation time before T-piece trial was 7.3 ± 4.1 days. Heart and respiratory parameters were similar for the two groups at 1 and 30 minutes of T-piece trial. The percentage of complications in the NPPV group was lower (28.6% versus 75.7%), with lower incidences of pneumonia and tracheotomy. Length of stay in the intensive care unit and mortality were not statistically different when comparing the groups. Conclusion The results suggest that NPPV is a good alternative for ventilation of patients who fail initial weaning attempts. NPPV reduces the incidence of pneumonia associated with mechanical ventilation and the need for tracheotomy. |
publishDate |
2008 |
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2008 |
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2010-05-05T04:15:48Z |
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Critical care. London. Vol. 12, no. 2 (Apr. 2008), p. 1-8 |
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