Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/147077 |
Resumo: | T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6–10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1β concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1β concentrations. A strict Supra regimen reduced IL-1β concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor. |
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Gomes, Sabrina CarvalhoAbascal, C.C.Haas, Alex NogueiraAngst, Patrícia Daniela MelchiorsOppermann, Rui VicenteMarcantonio, Rosemary Adriana Chierici2016-08-11T02:15:51Z20151806-8324http://hdl.handle.net/10183/147077000988183T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6–10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1β concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1β concentrations. A strict Supra regimen reduced IL-1β concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.application/pdfporBrazilian oral research. São Paulo. Vol. 29, no. 1 (2015), p. 1-8BiofilmesHábito de fumarPlaca dentariaDoenças periodontaisDental plaqueInterleukin-1BetaPeriodontal diseaseSmokingInfluence of supragingival biofilm control and smoking habit on Interleukin-1β concentrationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000988183.pdf000988183.pdfTexto completo (inglês)application/pdf383168http://www.lume.ufrgs.br/bitstream/10183/147077/1/000988183.pdf4a1cb3b26ef8b24335b03a1f49255a82MD51TEXT000988183.pdf.txt000988183.pdf.txtExtracted Texttext/plain29616http://www.lume.ufrgs.br/bitstream/10183/147077/2/000988183.pdf.txtfe0a88e4630c361d24f606fbc02f6e75MD52THUMBNAIL000988183.pdf.jpg000988183.pdf.jpgGenerated Thumbnailimage/jpeg1933http://www.lume.ufrgs.br/bitstream/10183/147077/3/000988183.pdf.jpgf148287a7362af6a2cb7ad332d3599deMD5310183/1470772018-10-29 08:33:09.389oai:www.lume.ufrgs.br:10183/147077Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-29T11:33:09Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
title |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
spellingShingle |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration Gomes, Sabrina Carvalho Biofilmes Hábito de fumar Placa dentaria Doenças periodontais Dental plaque Interleukin-1Beta Periodontal disease Smoking |
title_short |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
title_full |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
title_fullStr |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
title_full_unstemmed |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
title_sort |
Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration |
author |
Gomes, Sabrina Carvalho |
author_facet |
Gomes, Sabrina Carvalho Abascal, C.C. Haas, Alex Nogueira Angst, Patrícia Daniela Melchiors Oppermann, Rui Vicente Marcantonio, Rosemary Adriana Chierici |
author_role |
author |
author2 |
Abascal, C.C. Haas, Alex Nogueira Angst, Patrícia Daniela Melchiors Oppermann, Rui Vicente Marcantonio, Rosemary Adriana Chierici |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Sabrina Carvalho Abascal, C.C. Haas, Alex Nogueira Angst, Patrícia Daniela Melchiors Oppermann, Rui Vicente Marcantonio, Rosemary Adriana Chierici |
dc.subject.por.fl_str_mv |
Biofilmes Hábito de fumar Placa dentaria Doenças periodontais |
topic |
Biofilmes Hábito de fumar Placa dentaria Doenças periodontais Dental plaque Interleukin-1Beta Periodontal disease Smoking |
dc.subject.eng.fl_str_mv |
Dental plaque Interleukin-1Beta Periodontal disease Smoking |
description |
T his i nvestigation c ompared g ingival c revicular fl uid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6–10 mm) were obtained at the baseline, 30, and 180 days. IL-1β was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1β changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1β concentrations decreased from 3.2 pg/μL to 1.9 pg/μL. Higher baseline IL-1β concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1β concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1β concentrations. A strict Supra regimen reduced IL-1β concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
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2016-08-11T02:15:51Z |
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http://hdl.handle.net/10183/147077 |
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1806-8324 |
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000988183 |
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http://hdl.handle.net/10183/147077 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian oral research. São Paulo. Vol. 29, no. 1 (2015), p. 1-8 |
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openAccess |
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