COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders

Detalhes bibliográficos
Autor(a) principal: Quincozes-Santos, André
Data de Publicação: 2021
Outros Autores: Rosa, Rafael Lopes da, Cagnini, Emanuela Fernanda Tureta, Bobermin, Larissa Daniele, Oliveira, Markus Berger, Guimaraes, Jorge Almeida, Santi, Lucélia, Silva, Walter Orlando Beys da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/219463
Resumo: Coronavirus disease 2019 (COVID-19) was initially characterized due to its impacts on the respiratory system; however, many recent studies have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly affects the brain. COVID-19 can cause neurological complications, probably caused by the induction of a cytokine storm, since there is no evidence of neurotropism by SARS-CoV-2. In line with this, the COVID-19 outbreak could accelerate the progression or affect the clinical outcomes of neuropsychiatric conditions. Thus, we analyzed differential gene expression datasets for clinical samples of COVID-19 patients and identified 171 genes that are associated with the pathophysiology of the following neuropsychiatric disorders: alcohol dependence, autism, bipolar disorder, depression, panic disorder, schizophrenia, and sleep disorder. Several of the genes identified are associated with causing some of these conditions (classified as elite genes). Among these elite genes, 9 were found for schizophrenia, 6 for autism, 3 for depression/major depressive disorder, and 2 for alcohol dependence. The patients with the neuropsychiatric conditions associated with the genes identified may require special attention as COVID-19 can deteriorate or accelerate neurochemical dysfunctions, thereby aggravating clinical outcomes.
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spelling Quincozes-Santos, AndréRosa, Rafael Lopes daCagnini, Emanuela Fernanda TuretaBobermin, Larissa DanieleOliveira, Markus BergerGuimaraes, Jorge AlmeidaSanti, LucéliaSilva, Walter Orlando Beys da2021-04-06T04:19:33Z20212666-3546http://hdl.handle.net/10183/219463001123077Coronavirus disease 2019 (COVID-19) was initially characterized due to its impacts on the respiratory system; however, many recent studies have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly affects the brain. COVID-19 can cause neurological complications, probably caused by the induction of a cytokine storm, since there is no evidence of neurotropism by SARS-CoV-2. In line with this, the COVID-19 outbreak could accelerate the progression or affect the clinical outcomes of neuropsychiatric conditions. Thus, we analyzed differential gene expression datasets for clinical samples of COVID-19 patients and identified 171 genes that are associated with the pathophysiology of the following neuropsychiatric disorders: alcohol dependence, autism, bipolar disorder, depression, panic disorder, schizophrenia, and sleep disorder. Several of the genes identified are associated with causing some of these conditions (classified as elite genes). Among these elite genes, 9 were found for schizophrenia, 6 for autism, 3 for depression/major depressive disorder, and 2 for alcohol dependence. The patients with the neuropsychiatric conditions associated with the genes identified may require special attention as COVID-19 can deteriorate or accelerate neurochemical dysfunctions, thereby aggravating clinical outcomes.application/pdfengBrain, behavior, & immunity - health. [New York]. Vol. 11 (Feb. 2021), 100196, 5 p.Infecções por coronavirusTranstornos mentaisMarcadores genéticosCOVID-19Neuropsychiatric disordersMolecular markersElite genesNeuroinflammationCOVID-19 impacts the expression of molecular markers associated with neuropsychiatric disordersEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001123077.pdf.txt001123077.pdf.txtExtracted Texttext/plain29739http://www.lume.ufrgs.br/bitstream/10183/219463/2/001123077.pdf.txtb822c81decb4d94ad1de727bfbb5efdeMD52ORIGINAL001123077.pdfTexto completo (inglês)application/pdf1259655http://www.lume.ufrgs.br/bitstream/10183/219463/1/001123077.pdfcd65c26e4bbd3c7f2887eaca24b5bcadMD5110183/2194632023-03-05 03:23:19.273337oai:www.lume.ufrgs.br:10183/219463Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-05T06:23:19Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
title COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
spellingShingle COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
Quincozes-Santos, André
Infecções por coronavirus
Transtornos mentais
Marcadores genéticos
COVID-19
Neuropsychiatric disorders
Molecular markers
Elite genes
Neuroinflammation
title_short COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
title_full COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
title_fullStr COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
title_full_unstemmed COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
title_sort COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders
author Quincozes-Santos, André
author_facet Quincozes-Santos, André
Rosa, Rafael Lopes da
Cagnini, Emanuela Fernanda Tureta
Bobermin, Larissa Daniele
Oliveira, Markus Berger
Guimaraes, Jorge Almeida
Santi, Lucélia
Silva, Walter Orlando Beys da
author_role author
author2 Rosa, Rafael Lopes da
Cagnini, Emanuela Fernanda Tureta
Bobermin, Larissa Daniele
Oliveira, Markus Berger
Guimaraes, Jorge Almeida
Santi, Lucélia
Silva, Walter Orlando Beys da
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quincozes-Santos, André
Rosa, Rafael Lopes da
Cagnini, Emanuela Fernanda Tureta
Bobermin, Larissa Daniele
Oliveira, Markus Berger
Guimaraes, Jorge Almeida
Santi, Lucélia
Silva, Walter Orlando Beys da
dc.subject.por.fl_str_mv Infecções por coronavirus
Transtornos mentais
Marcadores genéticos
topic Infecções por coronavirus
Transtornos mentais
Marcadores genéticos
COVID-19
Neuropsychiatric disorders
Molecular markers
Elite genes
Neuroinflammation
dc.subject.eng.fl_str_mv COVID-19
Neuropsychiatric disorders
Molecular markers
Elite genes
Neuroinflammation
description Coronavirus disease 2019 (COVID-19) was initially characterized due to its impacts on the respiratory system; however, many recent studies have indicated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly affects the brain. COVID-19 can cause neurological complications, probably caused by the induction of a cytokine storm, since there is no evidence of neurotropism by SARS-CoV-2. In line with this, the COVID-19 outbreak could accelerate the progression or affect the clinical outcomes of neuropsychiatric conditions. Thus, we analyzed differential gene expression datasets for clinical samples of COVID-19 patients and identified 171 genes that are associated with the pathophysiology of the following neuropsychiatric disorders: alcohol dependence, autism, bipolar disorder, depression, panic disorder, schizophrenia, and sleep disorder. Several of the genes identified are associated with causing some of these conditions (classified as elite genes). Among these elite genes, 9 were found for schizophrenia, 6 for autism, 3 for depression/major depressive disorder, and 2 for alcohol dependence. The patients with the neuropsychiatric conditions associated with the genes identified may require special attention as COVID-19 can deteriorate or accelerate neurochemical dysfunctions, thereby aggravating clinical outcomes.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-04-06T04:19:33Z
dc.date.issued.fl_str_mv 2021
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dc.relation.ispartof.pt_BR.fl_str_mv Brain, behavior, & immunity - health. [New York]. Vol. 11 (Feb. 2021), 100196, 5 p.
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