The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/109966 |
Resumo: | Background: Although exercise training has well-known cardiorespiratory and metabolic benefits, low compliance with exercise training programs is a fact, and the harmful effects of physical detraining regarding these adaptations usually go unnoticed. We investigated the effects of exercise detraining on blood pressure, insulin sensitivity, and GLUT4 expression in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Methods: Studied animals were randomized into sedentary, trained (treadmill running/5 days a week, 60 min/day for 10 weeks), 1 week of detraining, and 2 weeks of detraining. Blood pressure (tail-cuff system), insulin sensitivity (kITT), and GLUT4 (Western blot) in heart, gastrocnemius and white fat tissue were measured.Results: Exercise training reduced blood pressure (19%), improved insulin sensitivity (24%), and increased GLUT4 in the heart (+34%); gastrocnemius (+36%) and fat (+22%) in SHR. In WKY no change in either blood pressure or insulin sensitivity were observed, but there was an increase in GLUT4 in the heart (+25%), gastrocnemius (+45%) and fat (+36%) induced by training. Both periods of detraining did not induce any change in neither blood pressure nor insulin sensitivity in SHR and WKY. One-week detraining reduced GLUT4 in SHR (heart: -28%; fat: -23%) and WKY (heart: -19%; fat: -22%); GLUT4 in the gastrocnemius was reduced after a 2-week detraining (SHR: -35%; WKY: -25%). There was a positive correlation between GLUT4 (gastrocnemius) and the maximal velocity in the exercise test (r = 0.60, p = 0.004). Conclusions: The study findings show that in detraining, despite reversion of the enhanced GLUT4 expression, cardiorespiratory and metabolic beneficial effects of exercise are preserved. |
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Lehnen, Alexandre MachadoLeguisamo, Natalia MottaPinto, Graziela HünningMarkoski, Melissa MedeirosAvila, Kátia de Angelis Lobo D.Machado, Ubiratan FabresSchaan, Beatriz D'Agord2015-02-11T02:18:08Z20101475-2840http://hdl.handle.net/10183/109966000771555Background: Although exercise training has well-known cardiorespiratory and metabolic benefits, low compliance with exercise training programs is a fact, and the harmful effects of physical detraining regarding these adaptations usually go unnoticed. We investigated the effects of exercise detraining on blood pressure, insulin sensitivity, and GLUT4 expression in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Methods: Studied animals were randomized into sedentary, trained (treadmill running/5 days a week, 60 min/day for 10 weeks), 1 week of detraining, and 2 weeks of detraining. Blood pressure (tail-cuff system), insulin sensitivity (kITT), and GLUT4 (Western blot) in heart, gastrocnemius and white fat tissue were measured.Results: Exercise training reduced blood pressure (19%), improved insulin sensitivity (24%), and increased GLUT4 in the heart (+34%); gastrocnemius (+36%) and fat (+22%) in SHR. In WKY no change in either blood pressure or insulin sensitivity were observed, but there was an increase in GLUT4 in the heart (+25%), gastrocnemius (+45%) and fat (+36%) induced by training. Both periods of detraining did not induce any change in neither blood pressure nor insulin sensitivity in SHR and WKY. One-week detraining reduced GLUT4 in SHR (heart: -28%; fat: -23%) and WKY (heart: -19%; fat: -22%); GLUT4 in the gastrocnemius was reduced after a 2-week detraining (SHR: -35%; WKY: -25%). There was a positive correlation between GLUT4 (gastrocnemius) and the maximal velocity in the exercise test (r = 0.60, p = 0.004). Conclusions: The study findings show that in detraining, despite reversion of the enhanced GLUT4 expression, cardiorespiratory and metabolic beneficial effects of exercise are preserved.application/pdfengCardiovascular diabetology. London. Vol. 9 (2010), 8 p.ExercícioRoedoresHipertensãoRatos endogâmicos SHRThe beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expressionEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000771555.pdf000771555.pdfTexto completo (inglês)application/pdf545852http://www.lume.ufrgs.br/bitstream/10183/109966/1/000771555.pdf881ab1df2636ea7971f098bf3a716a3bMD51TEXT000771555.pdf.txt000771555.pdf.txtExtracted Texttext/plain39504http://www.lume.ufrgs.br/bitstream/10183/109966/2/000771555.pdf.txtff5482b24d03daabb5ce43d92f9d7478MD52THUMBNAIL000771555.pdf.jpg000771555.pdf.jpgGenerated Thumbnailimage/jpeg2053http://www.lume.ufrgs.br/bitstream/10183/109966/3/000771555.pdf.jpgb9d56e29dd9b4eb828444cb8239be4a9MD5310183/1099662018-10-23 09:15:32.277oai:www.lume.ufrgs.br:10183/109966Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-23T12:15:32Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
title |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
spellingShingle |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression Lehnen, Alexandre Machado Exercício Roedores Hipertensão Ratos endogâmicos SHR |
title_short |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
title_full |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
title_fullStr |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
title_full_unstemmed |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
title_sort |
The beneficial effects of exercise in rodents are preserved after detraining : a phenomenon unrelated to GLUT4 expression |
author |
Lehnen, Alexandre Machado |
author_facet |
Lehnen, Alexandre Machado Leguisamo, Natalia Motta Pinto, Graziela Hünning Markoski, Melissa Medeiros Avila, Kátia de Angelis Lobo D. Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
author_role |
author |
author2 |
Leguisamo, Natalia Motta Pinto, Graziela Hünning Markoski, Melissa Medeiros Avila, Kátia de Angelis Lobo D. Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lehnen, Alexandre Machado Leguisamo, Natalia Motta Pinto, Graziela Hünning Markoski, Melissa Medeiros Avila, Kátia de Angelis Lobo D. Machado, Ubiratan Fabres Schaan, Beatriz D'Agord |
dc.subject.por.fl_str_mv |
Exercício Roedores Hipertensão Ratos endogâmicos SHR |
topic |
Exercício Roedores Hipertensão Ratos endogâmicos SHR |
description |
Background: Although exercise training has well-known cardiorespiratory and metabolic benefits, low compliance with exercise training programs is a fact, and the harmful effects of physical detraining regarding these adaptations usually go unnoticed. We investigated the effects of exercise detraining on blood pressure, insulin sensitivity, and GLUT4 expression in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Methods: Studied animals were randomized into sedentary, trained (treadmill running/5 days a week, 60 min/day for 10 weeks), 1 week of detraining, and 2 weeks of detraining. Blood pressure (tail-cuff system), insulin sensitivity (kITT), and GLUT4 (Western blot) in heart, gastrocnemius and white fat tissue were measured.Results: Exercise training reduced blood pressure (19%), improved insulin sensitivity (24%), and increased GLUT4 in the heart (+34%); gastrocnemius (+36%) and fat (+22%) in SHR. In WKY no change in either blood pressure or insulin sensitivity were observed, but there was an increase in GLUT4 in the heart (+25%), gastrocnemius (+45%) and fat (+36%) induced by training. Both periods of detraining did not induce any change in neither blood pressure nor insulin sensitivity in SHR and WKY. One-week detraining reduced GLUT4 in SHR (heart: -28%; fat: -23%) and WKY (heart: -19%; fat: -22%); GLUT4 in the gastrocnemius was reduced after a 2-week detraining (SHR: -35%; WKY: -25%). There was a positive correlation between GLUT4 (gastrocnemius) and the maximal velocity in the exercise test (r = 0.60, p = 0.004). Conclusions: The study findings show that in detraining, despite reversion of the enhanced GLUT4 expression, cardiorespiratory and metabolic beneficial effects of exercise are preserved. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
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2015-02-11T02:18:08Z |
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1475-2840 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Cardiovascular diabetology. London. Vol. 9 (2010), 8 p. |
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