Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267291 |
Resumo: | Pesticides are widely used in global agriculture to achieve high productivity levels. Among them, fungicides are specifically designed to inhibit fungal growth in crops and seeds. However, their application often results in environmental contamination, as these chemicals can persistently be detected in surface waters. This poses a potential threat to non-target organisms, including humans, that inhabit the affected ecosystems. In toxicologic research, the zebrafish (Danio rerio) is the most commonly used fish species to assess the potential effects of fungicide exposure, and numerous and sometimes conflicting findings have been reported. To address this, we conducted a systematic review and meta-analysis focusing on the neurobehavioral effects of fungicides in zebrafish. Our search encompassed three databases (PubMed, Scopus, and Web of Science), and the screening process followed predefined inclusion/exclusion criteria. We extracted qualitative and quantitative data, as well as assessed reporting quality, from 60 included studies. Meta-analyses were performed for the outcomes of distance traveled in larvae and adults and spontaneous movements in embryos. The results revealed a significant overall effect of fungicide exposure on distance, with a lower distance traveled in the exposed versus control group. No significant effect was observed for spontaneous movements. The overall heterogeneity was high for distance and moderate for spontaneous movements. The poor reporting practices in the field hindered a critical evaluation of the studies. Nevertheless, a sensitivity analysis did not identify any studies skewing the meta-analyses. This review underscores the necessity for better-designed and reported experiments in this field. |
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Reis, Carlos Guilherme RosaBastos, Leonardo MarensiChitolina, RafaelLopes, Matheus GallasZanona, Querusche KlippelBecker, Sofia ZaniniHerrmann, Ana PaulaPiato, Angelo Luis Stapassoli2023-11-18T03:27:03Z20232045-2322http://hdl.handle.net/10183/267291001187749Pesticides are widely used in global agriculture to achieve high productivity levels. Among them, fungicides are specifically designed to inhibit fungal growth in crops and seeds. However, their application often results in environmental contamination, as these chemicals can persistently be detected in surface waters. This poses a potential threat to non-target organisms, including humans, that inhabit the affected ecosystems. In toxicologic research, the zebrafish (Danio rerio) is the most commonly used fish species to assess the potential effects of fungicide exposure, and numerous and sometimes conflicting findings have been reported. To address this, we conducted a systematic review and meta-analysis focusing on the neurobehavioral effects of fungicides in zebrafish. Our search encompassed three databases (PubMed, Scopus, and Web of Science), and the screening process followed predefined inclusion/exclusion criteria. We extracted qualitative and quantitative data, as well as assessed reporting quality, from 60 included studies. Meta-analyses were performed for the outcomes of distance traveled in larvae and adults and spontaneous movements in embryos. The results revealed a significant overall effect of fungicide exposure on distance, with a lower distance traveled in the exposed versus control group. No significant effect was observed for spontaneous movements. The overall heterogeneity was high for distance and moderate for spontaneous movements. The poor reporting practices in the field hindered a critical evaluation of the studies. Nevertheless, a sensitivity analysis did not identify any studies skewing the meta-analyses. This review underscores the necessity for better-designed and reported experiments in this field.application/pdfengScientific reports. London. Vol. 13 (Oct. 2023), 18142, 20 p.EcotoxicologiaPraguicidasFungicidas industriaisPeixe-zebraRevisão sistemáticaNeurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysisEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001187749.pdf.txt001187749.pdf.txtExtracted Texttext/plain80015http://www.lume.ufrgs.br/bitstream/10183/267291/2/001187749.pdf.txt63018fcefbc9027d71f0b1097229a903MD52ORIGINAL001187749.pdfTexto completo (inglês)application/pdf3851054http://www.lume.ufrgs.br/bitstream/10183/267291/1/001187749.pdf057c87e7e870c416da698e52d577a624MD5110183/2672912023-11-19 04:21:49.85044oai:www.lume.ufrgs.br:10183/267291Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-19T06:21:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
title |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
spellingShingle |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis Reis, Carlos Guilherme Rosa Ecotoxicologia Praguicidas Fungicidas industriais Peixe-zebra Revisão sistemática |
title_short |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
title_full |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
title_fullStr |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
title_full_unstemmed |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
title_sort |
Neurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysis |
author |
Reis, Carlos Guilherme Rosa |
author_facet |
Reis, Carlos Guilherme Rosa Bastos, Leonardo Marensi Chitolina, Rafael Lopes, Matheus Gallas Zanona, Querusche Klippel Becker, Sofia Zanini Herrmann, Ana Paula Piato, Angelo Luis Stapassoli |
author_role |
author |
author2 |
Bastos, Leonardo Marensi Chitolina, Rafael Lopes, Matheus Gallas Zanona, Querusche Klippel Becker, Sofia Zanini Herrmann, Ana Paula Piato, Angelo Luis Stapassoli |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Reis, Carlos Guilherme Rosa Bastos, Leonardo Marensi Chitolina, Rafael Lopes, Matheus Gallas Zanona, Querusche Klippel Becker, Sofia Zanini Herrmann, Ana Paula Piato, Angelo Luis Stapassoli |
dc.subject.por.fl_str_mv |
Ecotoxicologia Praguicidas Fungicidas industriais Peixe-zebra Revisão sistemática |
topic |
Ecotoxicologia Praguicidas Fungicidas industriais Peixe-zebra Revisão sistemática |
description |
Pesticides are widely used in global agriculture to achieve high productivity levels. Among them, fungicides are specifically designed to inhibit fungal growth in crops and seeds. However, their application often results in environmental contamination, as these chemicals can persistently be detected in surface waters. This poses a potential threat to non-target organisms, including humans, that inhabit the affected ecosystems. In toxicologic research, the zebrafish (Danio rerio) is the most commonly used fish species to assess the potential effects of fungicide exposure, and numerous and sometimes conflicting findings have been reported. To address this, we conducted a systematic review and meta-analysis focusing on the neurobehavioral effects of fungicides in zebrafish. Our search encompassed three databases (PubMed, Scopus, and Web of Science), and the screening process followed predefined inclusion/exclusion criteria. We extracted qualitative and quantitative data, as well as assessed reporting quality, from 60 included studies. Meta-analyses were performed for the outcomes of distance traveled in larvae and adults and spontaneous movements in embryos. The results revealed a significant overall effect of fungicide exposure on distance, with a lower distance traveled in the exposed versus control group. No significant effect was observed for spontaneous movements. The overall heterogeneity was high for distance and moderate for spontaneous movements. The poor reporting practices in the field hindered a critical evaluation of the studies. Nevertheless, a sensitivity analysis did not identify any studies skewing the meta-analyses. This review underscores the necessity for better-designed and reported experiments in this field. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-11-18T03:27:03Z |
dc.date.issued.fl_str_mv |
2023 |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/267291 |
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001187749 |
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http://hdl.handle.net/10183/267291 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Scientific reports. London. Vol. 13 (Oct. 2023), 18142, 20 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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