Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/72411 |
Resumo: | The Neonatal Handling (NH) model presents a “blunted” corticosterone response to stress as well as an enhancement in contextual fear tasks. So the aim of this work was to examine a possible relationship between diminished imunosuppression over Interleukin 1 beta (IL-1) hippocampal levels and enhancement in aversive learning. To achieve that, we subjected male handled Wistar rats 30-35 and 90 days old to an inhibitory avoidance task, comparing the avoidance scores with respective hippocampal IL-1 levels at different time points. We found that handled adult animals learned the aversive task concomitantly with higher levels of hippocampal interleukin 1 beta 2h after footshock, while control animals showed diminished aversive learning and lower IL-1 beta levels at the same time. In the other hand, both handled and non-handled juvenile rats learned the aversive task, with no signal of immunosuppressant efect over interleukin 1 beta. However, basal levels of IL-1 beta were different between handled and non-handled animals in both ages, pointing a novel neuroimmunomodulation involvement to the NH model. |
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Nunes, Wagner de PaulaLucion, Aldo BoltenRocha, Cláudio Felipe Kolling da2013-06-13T01:45:27Z2012http://hdl.handle.net/10183/72411000881993The Neonatal Handling (NH) model presents a “blunted” corticosterone response to stress as well as an enhancement in contextual fear tasks. So the aim of this work was to examine a possible relationship between diminished imunosuppression over Interleukin 1 beta (IL-1) hippocampal levels and enhancement in aversive learning. To achieve that, we subjected male handled Wistar rats 30-35 and 90 days old to an inhibitory avoidance task, comparing the avoidance scores with respective hippocampal IL-1 levels at different time points. We found that handled adult animals learned the aversive task concomitantly with higher levels of hippocampal interleukin 1 beta 2h after footshock, while control animals showed diminished aversive learning and lower IL-1 beta levels at the same time. In the other hand, both handled and non-handled juvenile rats learned the aversive task, with no signal of immunosuppressant efect over interleukin 1 beta. However, basal levels of IL-1 beta were different between handled and non-handled animals in both ages, pointing a novel neuroimmunomodulation involvement to the NH model.application/pdfengSistema nervoso centralHipocampoInterleucina-1Manipulação neonatalAprendizagem da esquivaHippocampusInhibitory avoidanceIL-1 bInterleukin 1 betaNeonatal handlingEvidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal do Rio Grande do SulInstituto de Ciências Básicas da SaúdePorto Alegre, BR-RS2012Biomedicinagraduaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000881993.pdf000881993.pdfTexto completo (inglês)application/pdf253024http://www.lume.ufrgs.br/bitstream/10183/72411/1/000881993.pdfe2a05794333988f2930e39139ac9d1a1MD51TEXT000881993.pdf.txt000881993.pdf.txtExtracted Texttext/plain31123http://www.lume.ufrgs.br/bitstream/10183/72411/2/000881993.pdf.txt39417b4f728c0db348b9ce07677a886bMD52THUMBNAIL000881993.pdf.jpg000881993.pdf.jpgGenerated Thumbnailimage/jpeg1015http://www.lume.ufrgs.br/bitstream/10183/72411/3/000881993.pdf.jpgbfd4497ae489a1cda47031ebfa2393abMD5310183/724112023-07-20 03:36:30.719292oai:www.lume.ufrgs.br:10183/72411Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-07-20T06:36:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
title |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
spellingShingle |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats Nunes, Wagner de Paula Sistema nervoso central Hipocampo Interleucina-1 Manipulação neonatal Aprendizagem da esquiva Hippocampus Inhibitory avoidance IL-1 b Interleukin 1 beta Neonatal handling |
title_short |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
title_full |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
title_fullStr |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
title_full_unstemmed |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
title_sort |
Evidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled rats |
author |
Nunes, Wagner de Paula |
author_facet |
Nunes, Wagner de Paula |
author_role |
author |
dc.contributor.author.fl_str_mv |
Nunes, Wagner de Paula |
dc.contributor.advisor1.fl_str_mv |
Lucion, Aldo Bolten |
dc.contributor.advisor-co1.fl_str_mv |
Rocha, Cláudio Felipe Kolling da |
contributor_str_mv |
Lucion, Aldo Bolten Rocha, Cláudio Felipe Kolling da |
dc.subject.por.fl_str_mv |
Sistema nervoso central Hipocampo Interleucina-1 Manipulação neonatal Aprendizagem da esquiva |
topic |
Sistema nervoso central Hipocampo Interleucina-1 Manipulação neonatal Aprendizagem da esquiva Hippocampus Inhibitory avoidance IL-1 b Interleukin 1 beta Neonatal handling |
dc.subject.eng.fl_str_mv |
Hippocampus Inhibitory avoidance IL-1 b Interleukin 1 beta Neonatal handling |
description |
The Neonatal Handling (NH) model presents a “blunted” corticosterone response to stress as well as an enhancement in contextual fear tasks. So the aim of this work was to examine a possible relationship between diminished imunosuppression over Interleukin 1 beta (IL-1) hippocampal levels and enhancement in aversive learning. To achieve that, we subjected male handled Wistar rats 30-35 and 90 days old to an inhibitory avoidance task, comparing the avoidance scores with respective hippocampal IL-1 levels at different time points. We found that handled adult animals learned the aversive task concomitantly with higher levels of hippocampal interleukin 1 beta 2h after footshock, while control animals showed diminished aversive learning and lower IL-1 beta levels at the same time. In the other hand, both handled and non-handled juvenile rats learned the aversive task, with no signal of immunosuppressant efect over interleukin 1 beta. However, basal levels of IL-1 beta were different between handled and non-handled animals in both ages, pointing a novel neuroimmunomodulation involvement to the NH model. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2013-06-13T01:45:27Z |
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info:eu-repo/semantics/bachelorThesis |
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bachelorThesis |
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publishedVersion |
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000881993 |
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