Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/108649 |
Resumo: | OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (.7 times), bradycardic responses (.4 times), and vagal (,38%) and sympathetic effects (,36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance. |
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Konrad, Signorá PeresFarah, Vera M.A.Rodrigues, Bruno (Medicina)Wichi, Rogério BrandãoMachado, Ubiratan FabresLopes, Heno FerreiraSchaan, Beatriz D'AgordDe Angelis, KátiaIrigoyen, Maria Claudia Costa2014-12-25T02:10:00Z20121980-5322http://hdl.handle.net/10183/108649000877957OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (.7 times), bradycardic responses (.4 times), and vagal (,38%) and sympathetic effects (,36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.application/pdfengClinics. São Paulo. Vol. 67, n. 10 (out. 2012), p. 1209-1214Glutamato de sódioObesidadeResistência à insulinaPressão arterialMonosodium glutamateObesityInsulin resistanceArterial pressureAutonomic functionMonosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodentsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000877957.pdf000877957.pdfTexto completo (inglês)application/pdf319198http://www.lume.ufrgs.br/bitstream/10183/108649/1/000877957.pdfb66e1a96ab3e4ec4bdbc134cc00e5a14MD51TEXT000877957.pdf.txt000877957.pdf.txtExtracted Texttext/plain34446http://www.lume.ufrgs.br/bitstream/10183/108649/2/000877957.pdf.txtc58f55cae35a1ded269028d4e1e05efcMD52THUMBNAIL000877957.pdf.jpg000877957.pdf.jpgGenerated Thumbnailimage/jpeg1837http://www.lume.ufrgs.br/bitstream/10183/108649/3/000877957.pdf.jpg7ad13833ade28e6f615a511b8e5bb50cMD5310183/1086492018-10-30 07:52:04.612oai:www.lume.ufrgs.br:10183/108649Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-30T10:52:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
title |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
spellingShingle |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents Konrad, Signorá Peres Glutamato de sódio Obesidade Resistência à insulina Pressão arterial Monosodium glutamate Obesity Insulin resistance Arterial pressure Autonomic function |
title_short |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
title_full |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
title_fullStr |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
title_full_unstemmed |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
title_sort |
Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents |
author |
Konrad, Signorá Peres |
author_facet |
Konrad, Signorá Peres Farah, Vera M.A. Rodrigues, Bruno (Medicina) Wichi, Rogério Brandão Machado, Ubiratan Fabres Lopes, Heno Ferreira Schaan, Beatriz D'Agord De Angelis, Kátia Irigoyen, Maria Claudia Costa |
author_role |
author |
author2 |
Farah, Vera M.A. Rodrigues, Bruno (Medicina) Wichi, Rogério Brandão Machado, Ubiratan Fabres Lopes, Heno Ferreira Schaan, Beatriz D'Agord De Angelis, Kátia Irigoyen, Maria Claudia Costa |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Konrad, Signorá Peres Farah, Vera M.A. Rodrigues, Bruno (Medicina) Wichi, Rogério Brandão Machado, Ubiratan Fabres Lopes, Heno Ferreira Schaan, Beatriz D'Agord De Angelis, Kátia Irigoyen, Maria Claudia Costa |
dc.subject.por.fl_str_mv |
Glutamato de sódio Obesidade Resistência à insulina Pressão arterial |
topic |
Glutamato de sódio Obesidade Resistência à insulina Pressão arterial Monosodium glutamate Obesity Insulin resistance Arterial pressure Autonomic function |
dc.subject.eng.fl_str_mv |
Monosodium glutamate Obesity Insulin resistance Arterial pressure Autonomic function |
description |
OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (.7 times), bradycardic responses (.4 times), and vagal (,38%) and sympathetic effects (,36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2014-12-25T02:10:00Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/108649 |
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1980-5322 |
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000877957 |
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1980-5322 000877957 |
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http://hdl.handle.net/10183/108649 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Clinics. São Paulo. Vol. 67, n. 10 (out. 2012), p. 1209-1214 |
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openAccess |
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