Protocols of investigation of neonatal cholestasis : a critical appraisal
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267276 |
Resumo: | Neonatal cholestasis (NC) starts during the first three months of life and comprises extrahepatic and intrahepatic groups of diseases, some of which have high morbimortality rates if not timely identified and treated. Prolonged jaundice, clay-colored or acholic stools, and choluria in an infant indicate the urgent need to investigate the presence of NC, and thenceforth the differential diagnosis of extra- and intrahepatic causes of NC. The differential diagnosis of NC is a laborious process demanding the accurate exclusion of a wide range of diseases, through the skillful use and interpretation of several diagnostic tests. A wise integration of clinical-laboratory, histopathological, molecular, and genetic evaluations is imperative, employing extensive knowledge about each evaluated disease as well as the pitfalls of each diagnostic test. Here, we review the difficulties involved in correctly diagnosing the cause of cholestasis in an affected infant. |
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Quelhas, PatríciaJacinto, JoanaCerski, Carlos Thadeu SchmidtOliveira, Rui CaetanoOliveira, JorgeCarvalho, Elisa deSantos, Jorge Luiz dos2023-11-18T03:26:43Z20222227-9032http://hdl.handle.net/10183/267276001186985Neonatal cholestasis (NC) starts during the first three months of life and comprises extrahepatic and intrahepatic groups of diseases, some of which have high morbimortality rates if not timely identified and treated. Prolonged jaundice, clay-colored or acholic stools, and choluria in an infant indicate the urgent need to investigate the presence of NC, and thenceforth the differential diagnosis of extra- and intrahepatic causes of NC. The differential diagnosis of NC is a laborious process demanding the accurate exclusion of a wide range of diseases, through the skillful use and interpretation of several diagnostic tests. A wise integration of clinical-laboratory, histopathological, molecular, and genetic evaluations is imperative, employing extensive knowledge about each evaluated disease as well as the pitfalls of each diagnostic test. Here, we review the difficulties involved in correctly diagnosing the cause of cholestasis in an affected infant.application/pdfengHealthcare. Basel. Vol. 10 (2022), artigo 2012, 25 p.Colestase intra-hepáticaRecém-nascidoRevisãoDiagnóstico diferencialAtresia biliarCholestasisNeonatalDiagnosisDifferentialBiliary atresiaNeonatal intrahepaticProtocols of investigation of neonatal cholestasis : a critical appraisalEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001186985.pdf.txt001186985.pdf.txtExtracted Texttext/plain104952http://www.lume.ufrgs.br/bitstream/10183/267276/2/001186985.pdf.txt27c625605f31855991bc60836fb77b4eMD52ORIGINAL001186985.pdfTexto completo (inglês)application/pdf11230436http://www.lume.ufrgs.br/bitstream/10183/267276/1/001186985.pdf1e7e27e2f9dbdc0e349c1e1bde9402c2MD5110183/2672762023-11-19 04:21:41.926095oai:www.lume.ufrgs.br:10183/267276Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-19T06:21:41Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
title |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
spellingShingle |
Protocols of investigation of neonatal cholestasis : a critical appraisal Quelhas, Patrícia Colestase intra-hepática Recém-nascido Revisão Diagnóstico diferencial Atresia biliar Cholestasis Neonatal Diagnosis Differential Biliary atresia Neonatal intrahepatic |
title_short |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
title_full |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
title_fullStr |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
title_full_unstemmed |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
title_sort |
Protocols of investigation of neonatal cholestasis : a critical appraisal |
author |
Quelhas, Patrícia |
author_facet |
Quelhas, Patrícia Jacinto, Joana Cerski, Carlos Thadeu Schmidt Oliveira, Rui Caetano Oliveira, Jorge Carvalho, Elisa de Santos, Jorge Luiz dos |
author_role |
author |
author2 |
Jacinto, Joana Cerski, Carlos Thadeu Schmidt Oliveira, Rui Caetano Oliveira, Jorge Carvalho, Elisa de Santos, Jorge Luiz dos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Quelhas, Patrícia Jacinto, Joana Cerski, Carlos Thadeu Schmidt Oliveira, Rui Caetano Oliveira, Jorge Carvalho, Elisa de Santos, Jorge Luiz dos |
dc.subject.por.fl_str_mv |
Colestase intra-hepática Recém-nascido Revisão Diagnóstico diferencial Atresia biliar |
topic |
Colestase intra-hepática Recém-nascido Revisão Diagnóstico diferencial Atresia biliar Cholestasis Neonatal Diagnosis Differential Biliary atresia Neonatal intrahepatic |
dc.subject.eng.fl_str_mv |
Cholestasis Neonatal Diagnosis Differential Biliary atresia Neonatal intrahepatic |
description |
Neonatal cholestasis (NC) starts during the first three months of life and comprises extrahepatic and intrahepatic groups of diseases, some of which have high morbimortality rates if not timely identified and treated. Prolonged jaundice, clay-colored or acholic stools, and choluria in an infant indicate the urgent need to investigate the presence of NC, and thenceforth the differential diagnosis of extra- and intrahepatic causes of NC. The differential diagnosis of NC is a laborious process demanding the accurate exclusion of a wide range of diseases, through the skillful use and interpretation of several diagnostic tests. A wise integration of clinical-laboratory, histopathological, molecular, and genetic evaluations is imperative, employing extensive knowledge about each evaluated disease as well as the pitfalls of each diagnostic test. Here, we review the difficulties involved in correctly diagnosing the cause of cholestasis in an affected infant. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-11-18T03:26:43Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267276 |
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2227-9032 |
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001186985 |
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2227-9032 001186985 |
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http://hdl.handle.net/10183/267276 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Healthcare. Basel. Vol. 10 (2022), artigo 2012, 25 p. |
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openAccess |
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