Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/250744 |
Resumo: | Objective: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. Design and Methods: The sample involved 1,222 males and females from the 1978/79 Ribeira˜o Preto birth cohort, Brazil, aged 23–25 years. NWO was defined as body mass index (BMI) within the normal range (18.5–24.9 kg/m2) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) .23% in men and .30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. Results: In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84–16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95%CI 1.57–9.28), low insulin sensitivity (OR = 3.89; 95%CI 2.39–6.33), and high insulin secretion (OR = 2.17; 95%CI 1.24–3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95%CI 5.09–14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95%CI 1.11–2.47) and high triglyceride levels (OR = 1.93; 95%CI 1.02–3.64). Most estimates changed little after further adjustment for early and adult life variables. Conclusions: NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries. |
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Madeira, Francilene B.Silva, Antônio Augusto Moura daVeloso, Helma F.Goldani, Marcelo ZubaranKac, GilbertoCardoso, Viviane C.Bettiol, HeloisaBarbieri, Marco Antonio2022-11-04T04:38:29Z20131932-6203http://hdl.handle.net/10183/250744000908014Objective: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. Design and Methods: The sample involved 1,222 males and females from the 1978/79 Ribeira˜o Preto birth cohort, Brazil, aged 23–25 years. NWO was defined as body mass index (BMI) within the normal range (18.5–24.9 kg/m2) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) .23% in men and .30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. Results: In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84–16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95%CI 1.57–9.28), low insulin sensitivity (OR = 3.89; 95%CI 2.39–6.33), and high insulin secretion (OR = 2.17; 95%CI 1.24–3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95%CI 5.09–14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95%CI 1.11–2.47) and high triglyceride levels (OR = 1.93; 95%CI 1.02–3.64). Most estimates changed little after further adjustment for early and adult life variables. Conclusions: NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries.application/pdfengPloS one. San Francisco. Vol. 8, no. 3 (Mar. 2013), e60673, 9 p.ObesidadeSíndrome metabólicaAdulto jovemResistência à insulinaEstudos de coortesRibeirão Preto (SP)Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income countryEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000908014.pdf.txt000908014.pdf.txtExtracted Texttext/plain52741http://www.lume.ufrgs.br/bitstream/10183/250744/2/000908014.pdf.txtffa454f4bdf2f08b87ed681fc40d70bfMD52ORIGINAL000908014.pdfTexto completo (inglês)application/pdf179339http://www.lume.ufrgs.br/bitstream/10183/250744/1/000908014.pdfc9961f9d951e77f7884c5d39baa4ab93MD5110183/2507442022-11-05 04:49:36.576007oai:www.lume.ufrgs.br:10183/250744Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-11-05T07:49:36Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
title |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
spellingShingle |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country Madeira, Francilene B. Obesidade Síndrome metabólica Adulto jovem Resistência à insulina Estudos de coortes Ribeirão Preto (SP) |
title_short |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
title_full |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
title_fullStr |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
title_full_unstemmed |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
title_sort |
Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country |
author |
Madeira, Francilene B. |
author_facet |
Madeira, Francilene B. Silva, Antônio Augusto Moura da Veloso, Helma F. Goldani, Marcelo Zubaran Kac, Gilberto Cardoso, Viviane C. Bettiol, Heloisa Barbieri, Marco Antonio |
author_role |
author |
author2 |
Silva, Antônio Augusto Moura da Veloso, Helma F. Goldani, Marcelo Zubaran Kac, Gilberto Cardoso, Viviane C. Bettiol, Heloisa Barbieri, Marco Antonio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Madeira, Francilene B. Silva, Antônio Augusto Moura da Veloso, Helma F. Goldani, Marcelo Zubaran Kac, Gilberto Cardoso, Viviane C. Bettiol, Heloisa Barbieri, Marco Antonio |
dc.subject.por.fl_str_mv |
Obesidade Síndrome metabólica Adulto jovem Resistência à insulina Estudos de coortes Ribeirão Preto (SP) |
topic |
Obesidade Síndrome metabólica Adulto jovem Resistência à insulina Estudos de coortes Ribeirão Preto (SP) |
description |
Objective: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. Design and Methods: The sample involved 1,222 males and females from the 1978/79 Ribeira˜o Preto birth cohort, Brazil, aged 23–25 years. NWO was defined as body mass index (BMI) within the normal range (18.5–24.9 kg/m2) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) .23% in men and .30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. Results: In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84–16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95%CI 1.57–9.28), low insulin sensitivity (OR = 3.89; 95%CI 2.39–6.33), and high insulin secretion (OR = 2.17; 95%CI 1.24–3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95%CI 5.09–14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95%CI 1.11–2.47) and high triglyceride levels (OR = 1.93; 95%CI 1.02–3.64). Most estimates changed little after further adjustment for early and adult life variables. Conclusions: NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2022-11-04T04:38:29Z |
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Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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publishedVersion |
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http://hdl.handle.net/10183/250744 |
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1932-6203 |
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000908014 |
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1932-6203 000908014 |
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http://hdl.handle.net/10183/250744 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PloS one. San Francisco. Vol. 8, no. 3 (Mar. 2013), e60673, 9 p. |
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